An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development

Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding

(2014) R. B. Reinert et al.   DEVELOPMENT

The regulation of pre- and post-maturational plasticity of mammalian islet cell mass

(2014) Teresa Mezza et al.   DIABETOLOGIA

GDNF is required for neural colonization of the pancreas

(2013) J. L. Munoz-Bravo et al.   DEVELOPMENT

How to make a functional  -cell

(2013) F. W. Pagliuca et al.   DEVELOPMENT

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

(2013) Antigone S. Dimas et al.   DIABETES

Improved genetic testing for monogenic diabetes using targeted next-generation sequencing

(2013) S. Ellard et al.   DIABETOLOGIA

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation

(2013) T. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generating   Cells from Stem Cells--The Story So Far

(2013) M. Hebrok   Cold Spring Harbor Perspectives in Medicine

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity

(2012) Inês Pinheiro et al.   CELL

The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny

(2012) Shannon McKinney-Freeman et al.   Cell Stem Cell

Snail/Gfi-1 (SNAG) family zinc finger proteins in transcription regulation, chromatin dynamics, cell signaling, development, and disease

(2012) Cindy Chiang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Vascular instruction of pancreas development

(2012) O. Cleaver et al.   DEVELOPMENT

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency

(2012) E. De Franco et al.   DIABETES

Increased Expression of the Glucose-Responsive Gene,RCAN1, Causes Hypoinsulinemia, β-Cell Dysfunction, and Diabetes

(2012) Heshan Peiris et al.   ENDOCRINOLOGY

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Deconstructing Pancreas Developmental Biology

(2012) C. M. Benitez et al.   Cold Spring Harbor Perspectives in Biology

Physical Module Networks: an integrative approach for reconstructing transcription regulation

(2011) N. Novershtern et al.   BIOINFORMATICS

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Historical Perspective: Beginnings of the  -Cell: Current Perspectives in  -Cell Development

(2011) P. A. Seymour et al.   DIABETES

Transcriptomes of the major human pancreatic cell types

(2011) C. Dorrell et al.   DIABETOLOGIA

Genetics of type 2 diabetes: the GWAS era and future perspectives [Review]

(2011) Minako Imamura et al.   ENDOCRINE JOURNAL

Mutational analysis of RUNX1T1 gene in acute leukemias, breast and lung carcinomas

(2011) Yoo Ri Kim et al.   LEUKEMIA RESEARCH

AnimalTFDB: a comprehensive animal transcription factor database

(2011) H.-M. Zhang et al.   NUCLEIC ACIDS RESEARCH

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

(2011) J. Xu et al.   SCIENCE

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Deconstructing Pancreas Development to Reconstruct Human Islets from Pluripotent Stem Cells

(2010) Kristen D. McKnight et al.   Cell Stem Cell

Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium

(2010) Matthew Bjerknes et al.   DEVELOPMENTAL BIOLOGY

Cyclin D2 Is Essential for the Compensatory  -Cell Hyperplastic Response to Insulin Resistance in Rodents

(2010) S. Georgia et al.   DIABETES

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

(2010) J. van Arensbergen et al.   GENOME RESEARCH

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress

(2010) Sergei Chuikov et al.   NATURE CELL BIOLOGY

Module networks revisited: computational assessment and prioritization of model predictions

(2009) A. Joshi et al.   BIOINFORMATICS

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

(2009) Josselin Soyer et al.   DEVELOPMENT

Prdm16 is required for normal palatogenesis in mice

(2009) Bryan C. Bjork et al.   HUMAN MOLECULAR GENETICS

Developmental and species-divergent globin switching are driven by BCL11A

(2009) Vijay G. Sankaran et al.   NATURE

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

(2009) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

(2008) Philip A. Seymour et al.   DEVELOPMENTAL BIOLOGY

Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse

(2008) K. Juhl et al.   DIABETES

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

Clinical implications of a molecular genetic classification of monogenic β-cell diabetes

(2008) Rinki Murphy et al.   Nature clinical practice. Endocrinology & metabolism

Identification of transcripts with enriched expression in the developing and adult pancreas

(2008) Brad G Hoffman et al.   GENOME BIOLOGY