Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

(2018) Robert J. Ihry et al.   NATURE MEDICINE

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

(2018) Emma Haapaniemi et al.   NATURE MEDICINE

Cis - and Trans -Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics

(2018) Ryan J. McGinty et al.   TRENDS IN GENETICS

TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats

(2018) Valentine Mosbach et al.   Cell Reports

Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases

(2018) Magdalena Dabrowska et al.   Frontiers in Neuroscience

Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

(2017) Ryan J. McGinty et al.   GENOME RESEARCH

CRISPR/Cas9-Induced (CTG⋅CAG) n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing

(2017) Ellen L. van Agtmaal et al.   MOLECULAR THERAPY

CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10

(2017) Guo-Xiang Ruan et al.   MOLECULAR THERAPY

CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo

(2017) Alex Mas Monteys et al.   MOLECULAR THERAPY

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets

(2017) Shengdar Q Tsai et al.   NATURE METHODS

Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats

(2017) Jennifer H.G. Nguyen et al.   NUCLEIC ACIDS RESEARCH

CRISPR/Cas9-Mediated Deletion of CTG Expansions Recovers Normal Phenotype in Myogenic Cells Derived from Myotonic Dystrophy 1 Patients

(2017) Claudia Provenzano et al.   Molecular Therapy-Nucleic Acids

Recombination-independent recognition of DNA homology for repeat-induced point mutation

(2016) Eugene Gladyshev et al.   CURRENT GENETICS

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination

(2016) Yanfang Ye et al.   DNA REPAIR

Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks

(2016) Meghan M. Slean et al.   DNA REPAIR

Replication stalling and heteroduplex formation within CAG/CTG trinucleotide repeats by mismatch repair

(2016) David Viterbo et al.   DNA REPAIR

Deletion of the GAA repeats from the human frataxin gene using the CRISPR-Cas9 system in YG8R-derived cells and mouse models of Friedreich ataxia

(2016) D L Ouellet et al.   GENE THERAPY

Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9

(2016) Jun Wan Shin et al.   HUMAN MOLECULAR GENETICS

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

(2016) Jane C Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase

(2016) Cinzia Cinesi et al.   Nature Communications

The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

(2016) Jane C Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reactivation of FMR1 by CRISPR/Cas9-Mediated Deletion of the Expanded CGG-Repeat of the Fragile X Chromosome

(2016) Nina Xie et al.   PLoS One

MSH3 Promotes Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo

(2015) Gregory M. Williams et al.   GENETICS

Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia

(2015) Yanjie Li et al.   MOLECULAR THERAPY

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy

(2015) C. Long et al.   SCIENCE

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

(2015) M. Tabebordbar et al.   SCIENCE

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

(2015) C. E. Nelson et al.   SCIENCE

Genome Modification Leads to Phenotype Reversal in Human Myotonic Dystrophy Type 1 Induced Pluripotent Stem Cell-Derived Neural Stem Cells

(2015) Guangbin Xia et al.   STEM CELLS

Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons

(2015) Chul-Yong Park et al.   Cell Reports

MSH3 Promotes Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo

(2015) Gregory M. Williams et al.   GENETICS

Chromosome fragility and the abnormal replication of the FMR1 locus in fragile X syndrome

(2014) Dmitry Yudkin et al.   HUMAN MOLECULAR GENETICS

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast

(2014) Guy-Franck Richard et al.   PLoS One

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

The balancing act of DNA repeat expansions

(2013) Jane C Kim et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice

(2013) Stéphanie Tomé et al.   PLoS Genetics

Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

(2012) Mahru C. An et al.   Cell Stem Cell

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Break-induced replication: What is it and what is it for?

(2010) Bertrand Llorente et al.   CELL CYCLE

Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells

(2010) Guoqi Liu et al.   Nature Chemical Biology

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG{middle dot}CTG trinucleotide repeat

(2010) J. K. Blackwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-Strand Break Repair Pathways Protect against CAG/CTG Repeat Expansions, Contractions and Repeat-Mediated Chromosomal Fragility in Saccharomyces cerevisiae

(2009) R. Sundararajan et al.   GENETICS

Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast

(2009) Alexander A. Shishkin et al.   MOLECULAR CELL

SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

(2009) Alix Kerrest et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice

(2009) Stéphanie Tomé et al.   PLoS Genetics

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

(2008) Hyun-Min Kim et al.   EMBO JOURNAL

Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes

(2008) G.-F. Richard et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE