Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples

Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer

(2015) Surinder Kumar et al.   ANTIOXIDANTS & REDOX SIGNALING

A FRET-based assay for screening SIRT5 specific modulators

(2015) Yan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases

(2015) Claudia Roessler et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Development of a Simplified Microfluidic Injector for Analysis of Droplet Content via Capillary Electrophoresis

(2014) Michael F. DeLaMarre et al.   ANALYTICAL CHEMISTRY

Droplet Electrospray Ionization Mass Spectrometry for High Throughput Screening for Enzyme Inhibitors

(2014) Shuwen Sun et al.   ANALYTICAL CHEMISTRY

Subsecond Electrophoretic Separations from Droplet Samples for Screening of Enzyme Modulators

(2014) Erik D. Guetschow et al.   ANALYTICAL CHEMISTRY

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors

(2014) Claudia Roessler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Studying SIRT6 regulation using H3K56 based substrate and small molecules

(2014) Piia Kokkonen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Discovery of Novel and Selective SIRT6 Inhibitors

(2014) Marco Daniele Parenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer

(2014) Weidong Lu et al.   TUMOR BIOLOGY

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

High quality drug screening by capillary electrophoresis: A review

(2013) Meera Shanmuganathan et al.   ANALYTICA CHIMICA ACTA

Droplet-Interfaced Microchip and Capillary Electrophoretic Separations

(2013) Xize Niu et al.   ANALYTICAL CHEMISTRY

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Metabolic Characterization of a Sirt5 deficient mouse model

(2013) Jiujiu Yu et al.   Scientific Reports

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074

(2012) Benjamin Suenkel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A new nonpeptide substrate of human sirtuin in a capillary electrophoresis-based assay. Investigation of the binding mode by docking experiments

(2012) Hans Abromeit et al.   ELECTROPHORESIS

Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme

(2012) Andreas S. Madsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiosuccinyl Peptides as Sirt5-Specific Inhibitors

(2012) Bin He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

(2012) Frank Fischer et al.   PLoS One

Inhibitors of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5

(2012) Benjamin Maurer et al.   ACS Medicinal Chemistry Letters

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Parallel Electrophoretic Analysis of Segmented Samples On Chip for High-Throughput Determination of Enzyme Activities

(2010) Jian Pei et al.   ANALYTICAL CHEMISTRY

Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1

(2010) Masahito Ogura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An integrated on-chip sirtuin assay

(2010) Stefan Ohla et al.   ELECTROPHORESIS

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capillary electrophoresis-based sirtuin assay using non-peptide substrates

(2010) Yi Fan et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

9-Fluorenylmethoxycarbonyl-labeled peptides as substrates in a capillary electrophoresis-based assay for sirtuin enzymes

(2009) Yi Fan et al.   ANALYTICAL BIOCHEMISTRY

A continuous microplate assay for sirtuins and nicotinamide-producing enzymes

(2009) Brian C. Smith et al.   ANALYTICAL BIOCHEMISTRY

Analysis of Samples Stored as Individual Plugs in a Capillary by Electrospray Ionization Mass Spectrometry

(2009) Jian Pei et al.   ANALYTICAL CHEMISTRY

Microfluidic Chip for High Efficiency Electrophoretic Analysis of Segmented Flow from a Microdialysis Probe and in Vivo Chemical Monitoring

(2009) Meng Wang et al.   ANALYTICAL CHEMISTRY

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

Capillary microfluidic electrophoretic mobility shift assays: application to enzymatic assays in drug discovery

(2009) Dominique Perrin et al.   Expert Opinion on Drug Discovery

High-throughput assays for sirtuin enzymes: A microfluidic mobility shift assay and a bioluminescence assay

(2008) Yichin Liu et al.   ANALYTICAL BIOCHEMISTRY

Sampling and Electrophoretic Analysis of Segmented Flow Streams Using Virtual Walls in a Microfluidic Device

(2008) Gregory T. Roman et al.   ANALYTICAL CHEMISTRY

Development of a capillary electrophoresis-based assay of sirtuin enzymes

(2008) Yi Fan et al.   ELECTROPHORESIS