MiR-181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting TLR4

P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade

(2017) Qi Huang et al.   EPILEPSY RESEARCH

MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol

(2017) Paramananda Saikia et al.   HEPATOLOGY

Changes in serum miRNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy

(2016) Rainer Surges et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state

(2016) Sarah A. Woller et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of inflammation and its miRNA based regulation in epilepsy: Implications for therapy

(2016) Arpna Srivastava et al.   CLINICA CHIMICA ACTA

Quercetin attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways

(2016) Chengqiu Li et al.   GENE

Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy

(2016) L. Ren et al.   GENETICS AND MOLECULAR RESEARCH

MicroRNA-181b negatively regulates the proliferation of human epidermal keratinocytes in psoriasis through targeting TLR4

(2016) Cheng Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of p38 mitogen-activated protein kinase signaling reduces multidrug transporter activity and anti-epileptic drug resistance in refractory epileptic rats

(2016) Yiye Shao et al.   JOURNAL OF NEUROCHEMISTRY

Reduced AKT phosphorylation contributes to endoplasmic reticulum stress-mediated hippocampal neuronal apoptosis in rat recurrent febrile seizure

(2016) Yang Zhao et al.   LIFE SCIENCES

miR-181b-5p, miR-195-5p and miR-301a-3p are related with treatment resistance in schizophrenia

(2016) Huseyin Alacam et al.   PSYCHIATRY RESEARCH

Electroacupuncture enhances rehabilitation through miR-181b targeting PirB after ischemic stroke

(2016) Bin Deng et al.   Scientific Reports

Haemophilus parasuis induces activation of NF-κB and MAP kinase signaling pathways mediated by toll-like receptors

(2015) Yushan Chen et al.   MOLECULAR IMMUNOLOGY

Remember…there is more to epilepsy than seizures!

(2015) Andres M. Kanner et al.   NEUROLOGY

A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency

(2015) Lili Cui et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy

(2015) Jun Wang et al.   Scientific Reports

Epilepsy and innate immune system: A possible immunogenic predisposition and related therapeutic implications

(2015) Nassim Matin et al.   Human Vaccines & Immunotherapeutics

HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products

(2015) Yan Chen et al.   PLoS One

Stigma experience of people with epilepsy in Mexico and views of health care providers

(2014) Mariana Espínola-Nadurille et al.   EPILEPSY & BEHAVIOR

Association of TLR4 (D299G, T399I), TLR9 −1486T>C, TIRAP S180L and TNF-α promoter (−1031, −863, −857) polymorphisms with risk for systemic lupus erythematosus among South Indians

(2014) Y Rupasree et al.   LUPUS

MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy

(2014) Honghua Zheng et al.   MOLECULAR NEUROBIOLOGY

MicroRNA-103-1 Selectively Downregulates Brain NCX1 and Its Inhibition by Anti-miRNA Ameliorates Stroke Damage and Neurological Deficits

(2014) Antonio Vinciguerra et al.   MOLECULAR THERAPY

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Inflammatory Mediators in Epilepsy

(2013) Lourdes Lorigados Pedre et al.   CURRENT PHARMACEUTICAL DESIGN

Myoloid-Related Protein 8, an Endogenous Ligand of Toll-Like Receptor 4, Is Involved in Epileptogenesis of Mesial Temporal Lobe Epilepsy Via Activation of the Nuclear Factor-κB Pathway in Astrocytes

(2013) Na Gan et al.   MOLECULAR NEUROBIOLOGY

Toll-Like Receptor 4 Has an Essential Role in Early Skin Wound Healing

(2012) Lin Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor

(2012) Li Zhang et al.   Journal of Neuroinflammation

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

International Bureau for Epilepsy survey of children, teenagers, and young people with epilepsy: Data in China

(2009) Pei-min Yu et al.   EPILEPSY & BEHAVIOR

Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability

(2009) Kiarash Riazi et al.   EPILEPSY RESEARCH

Changes in sphingomyelinases, ceramide, Bax, Bcl2, and caspase-3 during and after experimental status epilepticus

(2008) Mohamad A. Mikati et al.   EPILEPSY RESEARCH