Journal
MOLECULAR IMMUNOLOGY
Volume 65, Issue 2, Pages 360-366Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2015.02.016
Keywords
Haemophilus parasuis; Inflammatory response; NF-kappa B pathway; MAPK pathway; TLRs
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Funding
- National Natural Science Foundation of China (NSFC) [31201931]
- National Basic Research Program (973 Program) [2012CB18802]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20110146120005]
- Fundamental Research Funds for the Central Universities (FRFCU) [2010QC003]
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Glasser's disease in pigs caused by Haemophilus parasuis is characterized by a severe membrane inflammation. In our previous study, we have identified activation of the transcription factor NF-kappa B after H. parasuis infection of porcine epithelial cells. In this study, we found that H. parasuis infection also contributed to the activation of p38/JNK MAPK pathway predominantly linked to inflammation, but not the ERK MAPK pathway associated with growth, differentiation and development. Inhibition of NF-kappa B, p38 and JNK but not ERK activity significantly reduced IL-8 and CCL4 expression by H. parasuis. We also found TLR1, TLR2,TLR4 and TLR6 were required for NF-kappa B, p38 and JNK MAPK activation. Furthermore, MyD88 and TRIF signaling cascades were essential for H. parasuis-induced NF-kappa B activation. These results provided new insights into the molecular pathways underlying the inflammatory response induced by H. parasuis. (C) 2015 Elsevier Ltd. All rights reserved.
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