Article
Chemistry, Multidisciplinary
Jia Tan, Binbin Ding, Hao Chen, Qi Meng, Jing Li, Chunzheng Yang, Wenying Zhang, Xinyang Li, Di Han, Pan Zheng, Ping'an Ma, Jun Lin
Summary: This article compares three commonly used mesoporous silica nanoparticles (MSNs) and finds that TMSN performs better than others in antigen loading, cellular uptake, ROS generation, lymph node targeting, immune activation, and therapeutic efficiency, providing a new paradigm for revealing the structure-function relationship of mesoporous silica nanoadjuvants, paving the way for their future clinical application.
Article
Biophysics
Xingyu Fan, Xiyu Gong, Fangfang Zhou, Botao Chen, Songwen Tan, Hui Xu, Anqiang Pan, Shuquan Liang, Yongju He
Summary: The design of a peroxidase-like nanozyme with drug delivery capability enables efficient tumor therapy through synergistic treatment, improving the efficacy of tumor treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Yanyan Zhang, Jiadong Lou, Gareth R. Williams, Yuhan Ye, Dandan Ren, Anhua Shi, Junzi Wu, Wenling Chen, Li-Min Zhu
Summary: In this study, pH-responsive mesoporous silica nanoparticles (MSN) were developed for targeted and synergistic anticancer therapy. The MSNs, functionalized with a histidine-tagged targeting peptide, showed pH-responsive drug release and effectively targeted tumor cells. The presence of an anticancer drug and Cu2+ enhanced the chemotherapeutic effect by generating reactive oxygen species. In vitro and in vivo experiments demonstrated the effective killing of tumor cells and diminished tumor volume without off-target toxicity. The functionalized MSNs show great potential for targeted and synergistic anticancer therapies.
Review
Biotechnology & Applied Microbiology
Han Wu, Xin-Fei Xu, Jia-Qi Zhu, Ming-Da Wang, Chao Li, Lei Liang, Hao Xing, Meng-Chao Wu, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: Mesoporous silica nanoparticles (MSNs) have shown potential in treating hepatocellular carcinoma by activating the immune system in cooperation with adjuvants. Research on MSN-based therapy for liver cancer is still in the exploratory stage, but there is promise for the development of new immunotherapeutic drugs for clinical management in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Cheng Xu, Hannah E. Dobson, Mengjie Yu, Wang Gong, Xiaoqi Sun, Kyung Soo Park, Andrew Kennedy, Xingwu Zhou, Jin Xu, Yao Xu, Andrew W. Tai, Yu Leo Lei, James J. Moon
Summary: This study developed a manganese-silica nanoplatform (MnOx@HMSN) that enhances the adjuvant effects of CDNs for vaccination against cancer and SARS-CoV-2. The nanoplatform efficiently co-loaded CDNs and antigens, resulting in robust immune responses and therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Environmental
Haoru Shan, Yang Si, Jianyong Yu, Bin Ding
Summary: This study successfully fabricated mesoporous structured silica nanofibrous membranes (MPSNMs) with high flexibility, specific surface area, and mesopore volume, showing excellent adsorption capability and recyclability towards tetracycline antibiotics. The adsorption mechanism is likely a synergistic effect of hydrogen-bonding interactions and electrostatic attraction between tetracycline and MPSNMs.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Su-Hwan Kim, Kwangsoo Shin, Byung-Gee Kim, Nathaniel S. S. Hwang, Taeghwan Hyeon
Summary: The combination of mesoporous silica nanoparticles (MSNs) and tyrosinase enables immediate adhesion and long-term sustainability of biological tissues, making it a promising strategy for tissue adhesives in clinical settings.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Wenfeng Zeng, Zimu Li, Qili Huang, Chendi Ding, Li Yang, Wenyan Wang, Zhaoqing Shi, Yao Yang, Hongzhong Chen, Lin Mei, Xiaowei Zeng
Summary: This article reports a multifunctional nanoplatform for synergistic photothermal and STING activation-based immunotherapy. The platform effectively delivers STING agonist MSA-2 to the tumor site and intelligently releases it through acid degradation facilitated by the photothermal effect. The platform also functions as an MRI contrast agent for real-time tracking. Experimental results show that this strategy has significant efficacy in inhibiting tumors and inducing immune responses.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Albert Yu, Xiaoyong Dai, Zixian Wang, Huaqing Chen, Bing Guo, Laiqiang Huang
Summary: Immunotherapy is a promising treatment modality for cancer, using the body's immune response to fight against cancer. Mesoporous silica, as a nanomaterial, can facilitate the advancement of immunotherapy with its high porosity and biocompatibility.
Article
Biochemistry & Molecular Biology
Yue-Mei Gao, Shih-Han Chiu, Prabhakar Busa, Chen-Lun Liu, Ranjith Kumar Kankala, Chia-Hung Lee
Summary: This study reports the fabrication of core-shell nanostructures for delivering methylene blue and copper-doxorubicin as model drugs for synergistic photodynamic therapy, chemotherapy, and chemodynamic therapy. The designed architectures demonstrate potent anti-cancer efficacy against skin melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Yawei Bao, Yong Cheng, Wei Liu, Wenguang Luo, Peijie Zhou, Dong Qian
Summary: Cancer is still the leading cause of disease related death, despite the potential of traditional therapies combined with tumor targeting or immunotherapy. Bacterial therapy, which has a long history, has regained attention recently, and can be optimized through biological engineering and chemical modification strategies to improve clinical efficiency and safety. This review summarizes recent studies on bacteria-mediated therapies combined with chemotherapy, radiotherapy, and immunotherapy, as well as bacterial detoxification and targeting strategies, applications, and clinical transformation prospects.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Blanca Escriche-Navarro, Andrea Escudero, Elena Lucena-Sanchez, Felix Sancenon, Alba Garcia-Fernandez, Ramon Martinez-Manez
Summary: Cancer immunotherapy has shown promise in treating various forms of cancer by stimulating the patient's immune system, but there are limitations to current treatments. The use of nanomaterials, particularly mesoporous silica nanoparticles (MSNs), has emerged as a potential tool to enhance cancer immunotherapy by improving efficacy and reducing side effects. This review explores the role of MSN and other nano/micro-materials in enhancing cancer immunotherapy and summarizes the different immunotherapeutic strategies addressed using MSN to date.
Article
Chemistry, Multidisciplinary
Eleonora Marconi, Igor Luisetto, Gabriella Di Carlo, Maria Paola Staccioli, Simonetta Tuti, Luca Tortora
Summary: Mesoporous silica nanoparticles (MSNPs) have been synthesized and functionalized into dendritic fibrous nanoparticles to create a smart delivery system for protective agents. The surface-modified MSNPs can serve as a reservoir for corrosion inhibitors and release them at different pH conditions.
Article
Chemistry, Multidisciplinary
Chenlu Huang, Li Zhang, Qing Guo, Yueyue Zuo, Nannan Wang, Hai Wang, Deling Kong, Dunwan Zhu, Linhua Zhang
Summary: The nanoparticle-based combination therapy of photothermal therapy (PTT) and immunotherapy shows promising potential for cancer treatment by ablating tumors and eliciting host immune responses.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Guobo Li, Yingying Zhang, Jie Yan, Yiwei Luo, Conghui Wang, Weiwei Feng, Shule Zhang, Wenming Liu, Zehui Zhang, Honggen Peng
Summary: A large surface area dendritic mesoporous silica material (KCC-1) was used to confine SnO2 nanoparticles, resulting in highly dispersed SnO2 NPs and improved CO catalytic oxidation activity. The Sn-x/KCC-1 catalysts exhibited excellent CO catalytic activity, with the Sn7@KCC-1 catalyst achieving 90% CO conversion at about 175 degrees C. The CO catalytic removal pathway was established, revealing the sequential steps: (1) CO -> CO3ads2-, (2) CO3ads2- -> CO2free+SnOx-1, (3) SnOx-1+O-2 -> SnOx+1. This study provides valuable insights into the design of high-efficiency non-precious metal catalysts for CO catalytic oxidation.
Article
Biochemistry & Molecular Biology
Shogo Hashimoto, Mayu Yasunaga, Motohiro Hirose, Masayuki Kakehata, Hidehiko Yashiro, Atsushi Yamazaki, Atsuo Ito
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Xia Li, Xiupeng Wang, Atsuo Ito, Noriko M. Tsuji
NATURE COMMUNICATIONS
(2020)
Article
Engineering, Biomedical
Lue Sun, Yu Sogo, Xiupeng Wang, Atsuo Ito
Summary: Universal data on the safety and toxicity of mesoporous silica (MS) particles are yet to be established for clinical purposes. Acute toxicity of MS particles is likely to arise from physical action after intravenous and intraperitoneal administrations, with no clear relationship with physicochemical properties. Hollow MS (HMS) particles showed lower inflammation-inducing ability than polyinosinic-polycytidylic acid and similar allergy-inducing ability as Alum. Lowest observed adverse effect levels for MS particle administration routes were determined.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Engineering, Biomedical
Xiupeng Wang, Xia Li, Atsuo Ito, Yu Sogo, Tadao Ohno
Summary: In this study, a combination therapy of an immune checkpoint inhibitor and an HMS-based cancer vaccine was proposed to enhance the therapeutic efficacy of the immune checkpoint inhibitor. The HMS-based cancer vaccine acts as an adjuvant to activate dendritic cells and present antigens. The results showed that the combination therapy reduced the required dose of the immune checkpoint inhibitor and increased the anti-tumor effect, along with increased CD4+ and CD8+ T cell populations.
ACTA BIOMATERIALIA
(2022)
Article
Medicine, General & Internal
Katsuya Nagashima, Yuki Hara, Hirotaka Mutsuzaki, Yasukazu Totoki, Eriko Okano, Kentaro Mataki, Yukei Matsumoto, Yohei Yanagisawa, Hiroshi Noguchi, Yu Sogo, Atsuo Ito, Masao Koda, Masashi Yamazaki
Summary: To solve the problem of instrument loosening, a novel coating material called fibroblast growth factor-2-calcium phosphate composite layer was developed to improve screw fixation strength. The primary goal of this study was to demonstrate the safety and feasibility of using screws coated with this composite layer for posterior instrumented surgery of the cervical spine. The results showed that the coated screws were safe and feasible, although there were a few cases of screw loosening.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Engineering, Manufacturing
Cijun Shuai, Desheng Li, Xiong Yao, Xia Li, Chengde Gao
Summary: Heterostructures are a new generation of materials/structures with dramatically different properties in heterogeneous zones. Additive manufacturing techniques have attracted attention in developing heterostructure due to their unique flexibility. This review summarizes the structural features, material systems, and synergistic effects of heterostructure. It also outlines the progress, advantages, properties, and applications of additive manufacturing in developing heterostructure, with a focus on biomedical applications such as bioscaffolds, vasculatures, biosensors, and biodetections. The future research directions and breakthroughs of heterostructure are also discussed.
INTERNATIONAL JOURNAL OF EXTREME MANUFACTURING
(2023)
Article
Engineering, Biomedical
Mayu Yasunaga, Fumiko Kobayashi, Yu Sogo, Kazutoshi Murotomi, Motohiro Hirose, Yuki Hara, Masashi Yamazaki, Atsuo Ito
Summary: This study demonstrated the enhancing effects of low-molecular-weight heparin (LMWH) incorporated into fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers on the biological activity of FGF-2 in vitro. The presence of LMWH increased the stability and amount of FGF-2 in the composite layers, leading to enhanced mitogenic and endothelial tube-forming activities, as well as osteogenic differentiation gene expression. These findings suggest that the LMWH-FGF-2-calcium phosphate composite layer holds promise as a coating for orthopedic and dental implants.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Biomaterials
Xueping Yu, Xiupeng Wang, Lue Sun, Atsushi Yamazaki, Xia Li
Summary: Radiotherapy (RT) has immune stimulation potency in cancer treatment, but its inhibitory effect on tumor growth and metastasis is limited. This study highlights the potential strategy of using SiO2@MnO2 nanoparticles (SM NPs) to regulate TME and enhance the effectiveness of RT and immunotherapy.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Biomaterials
Xueping Yu, Xiupeng Wang, Atsushi Yamazaki, Xia Li
Summary: Manganese-doped mesoporous silica nanoparticles (MM NPs) were used to regulate the tumor microenvironment (TME) and enhance the efficiency of chemotherapy and immunotherapy. The combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors showed synergistic efficiency in inhibiting tumor growth in a bilateral animal model. Additionally, Mn-doping endowed MSNs with six new regulatory functions for the TME.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Guowen Qian, Lemin Zhang, Xia Li, Cijun Shuai, Xiupeng Wang
Summary: Magnetite nanoparticles as drug carriers have precise drug targeting abilities but tend to aggregate in physiological environments. The Fe-MIL-88B-derived method of constructing Fe3O4-loaded mesoporous carbon systems provides a feasible solution to this issue and enables effective drug delivery. Fe-MIL-88B evenly distributes iron atoms through coordination bonds, and the mesoporous carbon generated after carbonization acts as a barrier against aggregation of Fe3O4 nanoparticles.
ACS APPLIED BIO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
