Sensing and regulation of cell volume – we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?

Effects of mechanical stretch on the functions of BK and L-type Ca 2+ channels in vascular smooth muscle cells

(2018) Zhiguo Zhang et al.   JOURNAL OF BIOMECHANICS

The α2β2 isoform combination dominates the astrocytic Na+ /K+ -ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation

(2017) Anca Stoica et al.   GLIA

Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms

(2017) Brian Roland Larsen et al.   GLIA

SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling

(2017) Jesse A. Stokum et al.   GLIA

Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes

(2017) Alexandra L. Schober et al.   JOURNAL OF PHYSIOLOGY-LONDON

When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor

(2017) Trine L. Toft-Bertelsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Stretch-activated TRPV2 channels: Role in mediating cardiopathies

(2017) Elizabeth Aguettaz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

L-Carnitine Reduces in Human Conjunctival Epithelial Cells Hypertonic-Induced Shrinkage through Interacting with TRPV1 Channels

(2017) Noushafarin Khajavi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes

(2017) Maria A. Tejada et al.   PLoS One

VRACs and other ion channels and transporters in the regulation of cell volume and beyond

(2016) Thomas J. Jentsch   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR)

(2016) Stine F. Pedersen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels

(2016) Andrew O. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Managing Brain Extracellular K+ during Neuronal Activity: The Physiological Role of the Na+/K+-ATPase Subunit Isoforms

(2016) Brian Roland Larsen et al.   Frontiers in Physiology

Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain

(2016) Jinwei Zhang et al.   Scientific Reports

The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

(2015) Ravi L. Rungta et al.   CELL

The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins

(2015) Maria Grazia Mola et al.   GLIA

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Muller Glia

(2015) A. O. Jo et al.   JOURNAL OF NEUROSCIENCE

Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading

(2015) A. B. Steffensen et al.   JOURNAL OF NEUROSCIENCE

Role of the Astrocytic Na+, K+-ATPase in K+ Homeostasis in Brain: K+ Uptake, Signaling Pathways and Substrate Utilization

(2015) Leif Hertz et al.   NEUROCHEMICAL RESEARCH

Volume-regulated anion channel—a frenemy within the brain

(2015) Alexander A. Mongin   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

K-Cl cotransporters, cell volume homeostasis, and neurological disease

(2015) Kristopher T. Kahle et al.   TRENDS IN MOLECULAR MEDICINE

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

A Novel Subtype of Astrocytes Expressing TRPV4 (Transient Receptor Potential Vanilloid 4) Regulates Neuronal Excitability via Release of Gliotransmitters

(2014) Koji Shibasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Swelling and Eicosanoid Metabolites Differentially Gate TRPV4 Channels in Retinal Neurons and Glia

(2014) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Involvement of TRPV4 channels in Aβ40-induced hippocampal cell death and astrocytic Ca2+ signalling

(2014) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

(2014) F. K. Voss et al.   SCIENCE

Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment

(2013) Ming Shi et al.   ACTA NEUROPATHOLOGICA

Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: A gene deletion study in mouse hippocampus

(2012) Nadia Nabil Haj-Yasein et al.   GLIA

Glial K+ Clearance and Cell Swelling: Key Roles for Cotransporters and Pumps

(2012) Nanna MacAulay et al.   NEUROCHEMICAL RESEARCH

The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

(2012) Olena Butenko et al.   PLoS One

Functional interaction between AQP2 and TRPV4 in renal cells

(2011) Luciano Galizia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

(2011) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

Hypertonicity Sensing in Organum Vasculosum Lamina Terminalis Neurons: A Mechanical Process Involving TRPV1 But Not TRPV4

(2011) S. Ciura et al.   JOURNAL OF NEUROSCIENCE

Increased Basal Activity Is a Key Determinant in the Severity of Human Skeletal Dysplasia Caused by TRPV4 Mutations

(2011) Stephen Loukin et al.   PLoS One

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

(2011) V. Benfenati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoregulation of the Na–K–2Cl and K–Cl cotransporters by the WNK kinases

(2010) Kristopher T. Kahle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture

(2010) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

(2010) A. S. Thrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure

(2009) Scott Earley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Water transport between CNS compartments: contributions of aquaporins and cotransporters

(2009) N. MacAulay et al.   NEUROSCIENCE

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells

(2008) Zan Pan et al.   CELL CALCIUM

Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation

(2008) Daniel Becker et al.   EUROPEAN JOURNAL OF CELL BIOLOGY