Increased Basal Activity Is a Key Determinant in the Severity of Human Skeletal Dysplasia Caused by TRPV4 Mutations

DominantTRPV4mutations in nonlethal and lethal metatropic dysplasia

(2010) Natalia Camacho et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: Age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice

(2010) Andrea L. Clark et al.   ARTHRITIS AND RHEUMATISM

Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forward Genetic Analysis Reveals Multiple Gating Mechanisms of TRPV4

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPV4-pathy, a novel channelopathy affecting diverse systems

(2010) Jin Dai et al.   JOURNAL OF HUMAN GENETICS

Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within the TRPV4 dysplasia family

(2010) J. Dai et al.   JOURNAL OF MEDICAL GENETICS

Interdomain Interactions Control Ca2+-Dependent Potentiation in the Cation Channel TRPV4

(2010) Rainer Strotmann et al.   PLoS One

Mutations in the Gene Encoding the Calcium-Permeable Ion Channel TRPV4 Produce Spondylometaphyseal Dysplasia, Kozlowski Type and Metatropic Dysplasia

(2009) Deborah Krakow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular Mechanisms of TRPV4-Mediated Neural Signaling

(2009) Wolfgang Liedtke   Annals of the New York Academy of Sciences

Global comparative transcriptome analysis of cartilage formation in vivo

(2009) Trevor L Cameron et al.   BMC DEVELOPMENTAL BIOLOGY

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease

(2009) G. Zhu et al.   HUMAN MOLECULAR GENETICS

Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation

(2009) Hueng-Chuen Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of the Transient Receptor Potential Vanilloid Channel TRPV4 by 4α-Phorbol Esters: A Structure−Activity Study

(2009) Thomas Kjær Klausen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of Transient Receptor Potential Vanilloid 4-Mediated Membrane Currents and Synaptic Transmission by Protein Kinase C

(2009) De-Shou Cao et al.   Molecular Pain

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

(2009) Michaela Auer-Grumbach et al.   NATURE GENETICS

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4

(2009) Han-Xiang Deng et al.   NATURE GENETICS

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

(2009) Guida Landouré et al.   NATURE GENETICS

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

(2009) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting metatropic dysplasia: Presentation of a series of 19 novel patients and review of the literature

(2008) D. Geneviève et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts

(2008) Ritsuko Masuyama et al.   Cell Metabolism

Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation

(2008) Daniel Becker et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Tyrosine Phosphorylation Modulates the Activity of TRPV4 in Response to Defined Stimuli

(2008) Tomasz Wegierski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IP3Receptor Binds to and Sensitizes TRPV4 Channel to Osmotic Stimuli via a Calmodulin-binding Site

(2008) Anna Garcia-Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IP3sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

(2008) Jacqueline Fernandes et al.   JOURNAL OF CELL BIOLOGY

Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss

(2008) Fumitaka Mizoguchi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia

(2008) Matthew J Rock et al.   NATURE GENETICS

A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating

(2008) Benjamin R. Myers et al.   NEURON

TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells

(2008) I. M. Lorenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone remodeling during fracture repair: The cellular picture

(2008) Aaron Schindeler et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY