Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis
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Title
Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis
Authors
Keywords
Myofibroblast, Fibrosis, Serotonin, Tryptophan, Kynurenine
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-07-20
DOI
10.1007/s00018-018-2880-2
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Note: Only part of the references are listed.- The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix
- (2018) Franco Klingberg et al. JOURNAL OF CELL SCIENCE
- An endogenous tryptophan photo-product, FICZ, is potentially involved in photo-aging by reducing TGF-β-regulated collagen homeostasis
- (2018) Mika Murai et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- The Safety and Tolerability of Topically Delivered Kynurenic Acid in Humans. A Phase 1 Randomized Double-Blind Clinical Trial
- (2018) Anthony Papp et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer
- (2018) Mariëlle Walraven et al. MATRIX BIOLOGY
- The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value
- (2018) Ángel C. Roman et al. PHARMACOLOGY & THERAPEUTICS
- 5-HT7 receptor antagonism (SB-269970) attenuates bleomycin-induced pulmonary fibrosis in rats via downregulating oxidative burden and inflammatory cascades and ameliorating collagen deposition: Comparison to terguride
- (2017) Mona K. Tawfik et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism
- (2017) Yang Li et al. FEBS Journal
- Activation of Wnt/β-catenin signalling is required for TGF-β/Smad2/3 signalling during myofibroblast proliferation
- (2017) Liang Xu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPK signaling pathways in human dermal fibroblasts
- (2017) David M. Dolivo et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Effects of tryptophan, kynurenine and kynurenic acid exerted on human reconstructed corneal epithelium in vitro
- (2017) Anna Matysik-Woźniak et al. Pharmacological Reports
- The relationship of SSRI and SNRI usage with interstitial lung disease and bronchiectasis in an elderly population: a case–control study
- (2017) Ted Rosenberg et al. Clinical Interventions in Aging
- Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder
- (2017) Armin Birner et al. PLoS One
- The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation
- (2016) Collynn F. Woeller et al. AMERICAN JOURNAL OF PATHOLOGY
- Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis
- (2016) Aaron R. Froese et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder
- (2016) Timothy B. Meier et al. BRAIN BEHAVIOR AND IMMUNITY
- The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle
- (2016) Muhamad A. Rostam et al. CELLULAR SIGNALLING
- The end of the road for the tryptophan depletion concept in pregnancy and infection
- (2016) A. A.- B. Badawy et al. CLINICAL SCIENCE
- Aryl hydrocarbon receptor-driven signals inhibit collagen synthesis in the gut
- (2016) Ivan Monteleone et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Myofibroblasts
- (2016) Boris Hinz EXPERIMENTAL EYE RESEARCH
- Development of a nanofibrous wound dressing with an antifibrogenic propertiesin vitroandin vivomodel
- (2016) Malihe-Sadat Poormasjedi-Meibod et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Kynurenine Modulates MMP-1 and Type-I Collagen Expression Via Aryl Hydrocarbon Receptor Activation in Dermal Fibroblasts
- (2016) Malihe-Sadat Poormasjedi-Meibod et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection
- (2016) Xavier Dagenais-Lussier et al. JOURNAL OF VIROLOGY
- The antifibrotic effects of alveolar macrophages 5-HT2C receptors blockade on bleomycin-induced pulmonary fibrosis in rats
- (2016) Samah M. Elaidy et al. Pharmacological Reports
- Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation
- (2016) J M Parrott et al. Translational Psychiatry
- Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis
- (2016) Michael D. Lovelace et al. Frontiers in Immunology
- The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice
- (2016) Hideyuki Ogiso et al. PLoS One
- Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling
- (2016) Sin Young Choi et al. PLoS One
- Tryptophan metabolism, disposition and utilization in pregnancy
- (2015) A. A.- B. Badawy BIOSCIENCE REPORTS
- Characterisation of the Kynurenine Pathway in Skin-Derived Fibroblasts and Keratinocytes
- (2015) Diba Sheipouri et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- AnIn-SituForming Skin Substitute Improves Healing Outcome in a Hypertrophic Scar Model
- (2015) Ryan Hartwell et al. TISSUE ENGINEERING PART A
- Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation
- (2014) Franco Klingberg et al. JOURNAL OF CELL BIOLOGY
- Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-β1/Smad3-mediated fibrotic responses through 5-HT2A receptors
- (2014) Chunyan Chen et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Anti-Scarring Properties of Different Tryptophan Derivatives
- (2014) Malihe-Sadat Poormasjedi-Meibod et al. PLoS One
- Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production
- (2014) Margaret M. Lowe et al. PLoS One
- The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway
- (2014) Haitao Yu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Linking phospholipase C isoforms with differentiation function in human vascular smooth muscle cells
- (2013) Louise S. Mackenzie et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells
- (2013) N. Aguilera-Montilla et al. BLOOD
- Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts
- (2013) Diana TA Ploeger et al. Cell Communication and Signaling
- The expanding roles of 1-methyl-tryptophan (1-MT): in addition to inhibiting kynurenine production, 1-MT activates the synthesis of melatonin in skin cells
- (2013) Ana C. R. Moreno et al. FEBS Journal
- Indoleamine 2,3-Dioxygenase Activity Contributes to Local Immune Suppression in the Skin Expressing Human Papillomavirus Oncoprotein E7
- (2013) Deepak Mittal et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Kynurenine Increases Matrix Metalloproteinase-1 and -3 Expression in Cultured Dermal Fibroblasts and Improves Scarring In Vivo
- (2013) Yunyuan Li et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Immuno-Regulatory Function of Indoleamine 2,3 Dioxygenase through Modulation of Innate Immune Responses
- (2013) Malihe-Sadat Poormasjedi-Meibod et al. PLoS One
- Therapy for Fibrotic Diseases: Nearing the Starting Line
- (2013) S. L. Friedman et al. Science Translational Medicine
- Serotonin paracrine signaling in tissue fibrosis
- (2012) Derek A. Mann et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Effects of indoleamine 2,3-dioxygenases in carbon tetrachloride-induced hepatitis model of rats
- (2012) Dan Li et al. CELL BIOCHEMISTRY AND FUNCTION
- The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
- (2012) Timothy V. Beischlag et al. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
- Application of an Indoleamine 2,3-Dioxygenase–Expressing Skin Substitute Improves Scar Formation in a Fibrotic Animal Model
- (2012) Claudia Chavez-Munoz et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
- (2012) Chris Hough et al. PLoS One
- Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
- (2012) Alfiya Akhmetshina et al. Nature Communications
- The Aryl Hydrocarbon Receptor Ligand ITE Inhibits TGFβ1-Induced Human Myofibroblast Differentiation
- (2011) Geniece M. Lehmann et al. AMERICAN JOURNAL OF PATHOLOGY
- Serotonin Activates Dendritic Cell Function in the Context of Gut Inflammation
- (2011) Nan Li et al. AMERICAN JOURNAL OF PATHOLOGY
- Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver
- (2011) Edward Dere et al. BMC GENOMICS
- Platelet-derived serotonin links vascular disease and tissue fibrosis
- (2011) Clara Dees et al. JOURNAL OF EXPERIMENTAL MEDICINE
- An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
- (2011) Christiane A. Opitz et al. NATURE
- Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an NPHP2 mouse model
- (2011) Noriyuki Sugiyama et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease
- (2011) Hoeke A. Baarsma et al. PLoS One
- TGF- IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
- (2010) Z. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Macrophages: Master Regulators of Inflammation and Fibrosis
- (2010) Thomas Wynn et al. SEMINARS IN LIVER DISEASE
- Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor
- (2010) Colin A. Flaveny et al. TOXICOLOGICAL SCIENCES
- Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling
- (2010) Brett C. DiNatale et al. TOXICOLOGICAL SCIENCES
- Serotonin release and uptake in the gastrointestinal tract
- (2009) Paul P. Bertrand et al. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
- Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
- (2009) Claudio Alarcón et al. CELL
- The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance
- (2009) Shin-ichiro Imai CELL BIOCHEMISTRY AND BIOPHYSICS
- Transforming Growth Factor-β-inducible Phosphorylation of Smad3
- (2009) Guannan Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Platelet derived serotonin drives the activation of rat cardiac fibroblasts by 5-HT2A receptors
- (2009) Samiye Yabanoglu et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- 5-Hydroxytryptamine Modulates Migration, Cytokine and Chemokine Release and T-Cell Priming Capacity of Dendritic Cells In Vitro and In Vivo
- (2009) Tobias Müller et al. PLoS One
- 5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population – authors' response
- (2009) Lorenzo Beretta et al. ARTHRITIS RESEARCH & THERAPY
- 5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population
- (2009) Holger Kirsten et al. ARTHRITIS RESEARCH & THERAPY
- The mouse and human Ah receptor differ in recognition of LXXLL motifs
- (2008) Colin Flaveny et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Phospho-control of TGF-β superfamily signaling
- (2008) Katharine H Wrighton et al. CELL RESEARCH
- Serotonin and Angiotensin Receptors in Cardiac Fibroblasts Coregulate Adrenergic-Dependent Cardiac Hypertrophy
- (2008) Fabrice Jaffré et al. CIRCULATION RESEARCH
- Cross-talk between Aryl Hydrocarbon Receptor and Mitogen-Activated Protein Kinase Signaling Pathway in Liver Cancer through c-raf Transcriptional Regulation
- (2008) J. Borlak et al. MOLECULAR CANCER RESEARCH
- The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
- (2008) Marc Veldhoen et al. NATURE
- Delayed inhibition of p38 mitogen-activated protein kinase ameliorates renal fibrosis in obstructive nephropathy
- (2008) M. Nishida et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation
- (2008) Lorenzo Beretta et al. ARTHRITIS RESEARCH & THERAPY
- The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
- (2007) Linh P. Nguyen et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Cellular and molecular mechanisms of fibrosis
- (2007) TA Wynn JOURNAL OF PATHOLOGY
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