Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

(2016) Jennifer M. Parrott et al.   Journal of Neuroinflammation

Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis

(2016) S Georgin-Lavialle et al.   MOLECULAR PSYCHIATRY

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory

(2015) Jillian M. Heisler et al.   BRAIN BEHAVIOR AND IMMUNITY

A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality

(2015) Cecilie Bay-Richter et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice

(2015) Dániel Varga et al.   Frontiers in Behavioral Neuroscience

The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry

(2014) Thomas R. Insel   AMERICAN JOURNAL OF PSYCHIATRY

Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

(2014) Jonathan Savitz et al.   NEUROPSYCHOPHARMACOLOGY

Targeted Deletion of Kynurenine 3-Monooxygenase in Mice

(2013) Flaviano Giorgini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Hippocampal Synaptic Transmission by the Kynurenine Pathway Member Xanthurenic Acid and Other VGLUT Inhibitors

(2013) S A Neale et al.   NEUROPSYCHOPHARMACOLOGY

Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression

(2013) Andrew H Miller   NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

(2013) Rafael Lugo-Huitrón et al.   Oxidative Medicine and Cellular Longevity

Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice

(2012) Angela W. Corona et al.   BRAIN BEHAVIOR AND IMMUNITY

Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge

(2012) Alexander Salazar et al.   HORMONES AND BEHAVIOR

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Enhancement of Dorsal Hippocampal Activity by Knockdown of HCN1 Channels Leads to Anxiolytic- and Antidepressant-like Behaviors

(2012) Chung Sub Kim et al.   NEURON

Actions of Xanthurenic Acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus

(2012) C.S. Copeland et al.   NEUROPHARMACOLOGY

Immune system to brain signaling: Neuropsychopharmacological implications

(2011) Lucile Capuron et al.   PHARMACOLOGY & THERAPEUTICS

Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans

(2011) Jan-Sebastian Grigoleit et al.   PLoS One

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Assessment of spatial memory in mice

(2010) Sunita Sharma et al.   LIFE SCIENCES

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning

(2009) Amy C. Chess et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior

(2009) J. C. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

(2009) Stephen J Pettitt et al.   NATURE METHODS

Peripheral Inflammation is Associated with Altered Substantia Nigra Activity and Psychomotor Slowing in Humans

(2008) Lena Brydon et al.   BIOLOGICAL PSYCHIATRY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide

(2008) J. P. Konsman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

(2008) Caroline André et al.   JOURNAL OF NEUROIMMUNOLOGY

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE