Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

Nucleotide metabolism, oncogene-induced senescence and cancer

(2015) Katherine M. Aird et al.   CANCER LETTERS

Cyclin L2 Is a Critical HIV Dependency Factor in Macrophages that Controls SAMHD1 Abundance

(2015) George Boateng Kyei et al.   Cell Host & Microbe

SAMHD1 prevents autoimmunity by maintaining genome stability

(2014) Stefanie Kretschmer et al.   ANNALS OF THE RHEUMATIC DISEASES

SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors

(2014) Ester Ballana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

(2014) Wei Chen et al.   Autophagy

MicroRNA-181 expression regulates specific post-transcriptional level of SAMHD1 expression in vitro

(2014) Changzhong Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation

(2014) Jia-lei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Hepatitis B virus replication by SAMHD1

(2014) Zhangming Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells

(2014) Eduardo Pauls et al.   JOURNAL OF IMMUNOLOGY

Identification of Cellular Proteins Interacting with the Retroviral Restriction Factor SAMHD1

(2014) C. St. Gelais et al.   JOURNAL OF VIROLOGY

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

(2014) Y Aye et al.   ONCOGENE

Structural basis of cellular dNTP regulation by SAMHD1

(2014) X. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p21 regulates the HIV-1 restriction factor SAMHD1

(2014) E. Pauls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage

(2013) R. Clifford et al.   BLOOD

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

(2013) Dan A. Landau et al.   CELL

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

SAMHD1-dependent retroviral control and escape in mice

(2013) Jan Rehwinkel et al.   EMBO JOURNAL

Promoter Methylation RegulatesSAMHD1Gene Expression in Human CD4+T Cells

(2013) Suresh de Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of SAMHD1 Expression Correlates with Promoter DNA Methylation in Sézary Syndrome Patients

(2013) Suresh de Silva et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication

(2013) Eui Tae Kim et al.   JOURNAL OF VIROLOGY

Mechanism of allosteric activation of SAMHD1 by dGTP

(2013) Xiaoyun Ji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of diverse retroviruses by SAMHD1

(2013) Thomas Gramberg et al.   Retrovirology

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1

(2013) Ke Zhao et al.   Cell Reports

Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response

(2013) Rayk Behrendt et al.   Cell Reports

Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1

(2013) Alexandra Cribier et al.   Cell Reports

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

(2012) B. A. Walker et al.   BLOOD

Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

(2012) A. Schuh et al.   BLOOD

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

(2012) J. Liu et al.   GENOME RESEARCH

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Evolving Insights in the Pathogenesis and Therapy of Cutaneous T-cell lymphoma (Mycosis Fungoides and Sezary Syndrome)

(2011) Henry K. Wong et al.   BRITISH JOURNAL OF HAEMATOLOGY

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

A Review Comparing Deoxyribonucleoside Triphosphate (dNTP) Concentrations in the Mitochondrial and Cytoplasmic Compartments of Normal and Transformed Cells

(2011) Vishal V. Gandhi et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Nucleic acid metabolism and systemic autoimmunity revisited

(2010) Min Ae Lee-Kirsch   ARTHRITIS AND RHEUMATISM

Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells

(2010) Hiroyuki Niida et al.   CANCER SCIENCE

A large homozygous deletion in the SAMHD1 gene causes atypical Aicardi–Goutiéres syndrome associated with mtDNA deletions

(2010) Esther Leshinsky-Silver et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

(2010) Chiara Rampazzo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

(2010) Dinesh Kumar et al.   NUCLEIC ACIDS RESEARCH

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Nucleoside analogs: molecular mechanisms signaling cell death

(2008) B Ewald et al.   ONCOGENE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE