Emerging roles and regulation of MiT/TFE transcriptional factors

MITF acts as an anti-oxidant transcription factor to regulate mitochondrial biogenesis and redox signaling in retinal pigment epithelial cells

(2018) Jiajia Hua et al.   EXPERIMENTAL EYE RESEARCH

FBXW7 regulates a mitochondrial transcription program by modulating MITF

(2018) Franco Abbate et al.   Pigment Cell & Melanoma Research

Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling

(2018) Zhidan Chen et al.   Theranostics

Sclerosing TFEB -rearrangement renal cell carcinoma: a recurring histologic pattern

(2017) Sean R. Williamson et al.   HUMAN PATHOLOGY

The MiTF/TFE Family of Transcription Factors: Master Regulators of Organelle Signaling, Metabolism, and Stress Adaptation

(2017) Logan Slade et al.   MOLECULAR CANCER RESEARCH

TFE3 regulates renal adenocarcinoma cell proliferation via activation of the mTOR pathway

(2017) Yuan Fang et al.   Molecular Medicine Reports

A rare case of TFE-related pigmented renal tumor with overlapping features between melanotic Xp11 translocation renal cancer and Xp11 renal cell carcinoma with melanotic features

(2017) Leonardo Cardili et al.   PATHOLOGY INTERNATIONAL

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

(2017) Chiara Di Malta et al.   SCIENCE

Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis

(2017) Lorena Fernández-Mosquera et al.   Scientific Reports

Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features

(2017) Kentaro Inamura   Cancers

DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway

(2016) Valentina Bouché et al.   Autophagy

Modeling Alveolar Soft Part Sarcoma Unveils Novel Mechanisms of Metastasis

(2016) Miwa Tanaka et al.   CANCER RESEARCH

The awesome lysosome

(2016) A. Ballabio   EMBO Molecular Medicine

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

(2016) Peter A. Humphrey et al.   EUROPEAN UROLOGY

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells

(2016) Min Li et al.   JOURNAL OF PINEAL RESEARCH

Turn up the lysosome

(2016) Paul Saftig et al.   NATURE CELL BIOLOGY

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

Transcription Factor Tfe3 Directly Regulates Pgc-1alpha in Muscle

(2015) Nunciada Salma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

(2015) A. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer

(2015) Alexandra Giatromanolaki et al.   LUNG CANCER

Regulation of the Transcription Factor EB-PGC1α Axis by Beclin-1 Controls Mitochondrial Quality and Cardiomyocyte Death under Stress

(2015) Xiucui Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis

(2015) Diego Ploper et al.   PHARMACOLOGICAL RESEARCH

Increased glucocerebrosidase expression and activity in preeclamptic placenta

(2015) J.M. Jebbink et al.   PLACENTA

MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells

(2015) Diego Ploper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

(2015) Yuchen Feng et al.   TRENDS IN CELL BIOLOGY

Angiotensin II stimulates melanogenesis via the protein kinase C pathway

(2015) LI-HONG LIU et al.   Experimental and Therapeutic Medicine

PGC-1α modulates denervation-induced mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   Skeletal Muscle

Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis

(2014) José A. Martina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

A RANKL-PKC -TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts

(2013) M. Ferron et al.   GENES & DEVELOPMENT

GCN5-like Protein 1 (GCN5L1) Controls Mitochondrial Content through Coordinated Regulation of Mitochondrial Biogenesis and Mitophagy

(2013) Iain Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

(2013) Jose A. Martina et al.   JOURNAL OF CELL BIOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease

(2012) Albert R. La Spada   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF

(2012) V. Pogenberg et al.   GENES & DEVELOPMENT

Transcription factor E3, a major regulator of mast cell–mediated allergic response

(2012) Zohar Yagil et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Diverse Fusion Patterns and Heterogeneous Clinicopathologic Features of Renal Cell Carcinoma With t(6;11) Translocation

(2011) Kentaro Inamura et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Fifteen-year quest for microphthalmia-associated transcription factor target genes

(2009) Yann Cheli et al.   Pigment Cell & Melanoma Research

Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF

(2008) K. Bharti et al.   DEVELOPMENT