From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta

Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media

(2017) K.Y. Chooi et al.   JOURNAL OF BIOMECHANICS

Understanding the fluid mechanics behind transverse wall shear stress

(2017) Yumnah Mohamied et al.   JOURNAL OF BIOMECHANICS

Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

(2017) Jorge Oller et al.   NATURE MEDICINE

The collαgen III fibril has a “flexi-rod” structure of flexible sequences interspersed with rigid bioactive domains including two with hemostatic roles

(2017) J. Des Parkin et al.   PLoS One

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling

(2017) Hao Wei et al.   Journal of the American Heart Association

Connective tissue growth factor (CTGF) in age-related vascular pathologies

(2017) Zoltan Ungvari et al.   GeroScience

Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and DissectionsHighlights

(2016) Dianna M. Milewicz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance

(2016) P. G. W. Gettins et al.   BIOCHEMICAL JOURNAL

Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases — nomenclature and diagnostic criteria

(2016) Marc K. Halushka et al.   CARDIOVASCULAR PATHOLOGY

The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle

(2016) Muhamad A. Rostam et al.   CELLULAR SIGNALLING

LOXMutations Predispose to Thoracic Aortic Aneurysms and DissectionsNovelty and Significance

(2016) Dong-chuan Guo et al.   CIRCULATION RESEARCH

International Registry of Patients Carrying TGFBR1 or TGFBR2 MutationsCLINICAL PERSPECTIVE

(2016) Guillaume Jondeau et al.   Circulation-Cardiovascular Genetics

Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections

(2016) Josephina A.N. Meester et al.   GENETICS IN MEDICINE

FOXE3 mutations predispose to thoracic aortic aneurysms and dissections

(2016) Shao-Qing Kuang et al.   JOURNAL OF CLINICAL INVESTIGATION

Intimal and medial contributions to the hydraulic resistance of the arterial wall at different pressures: a combined computational and experimental study

(2016) K. Y. Chooi et al.   Journal of the Royal Society Interface

Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage

(2016) Kevin Retailleau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Loss of function mutation inLOXcauses thoracic aortic aneurysm and dissection in humans

(2016) Vivian S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

International Registry of Patients Carrying TGFBR1 or TGFBR2 MutationsCLINICAL PERSPECTIVE

(2016) Guillaume Jondeau et al.   Circulation-Cardiovascular Genetics

Uptake of Plasmin-PN-1 Complexes in Early Human Atheroma

(2016) Kamel Boukais et al.   Frontiers in Physiology

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

(2016) Xiaofeng Chen et al.   PLoS One

β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice

(2016) Weihong Ren et al.   Scientific Reports

MAT2A Mutations Predispose Individuals to Thoracic Aortic Aneurysms

(2015) Dong-chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epigenetic Profiling Identifies Novel Genes for Ascending Aortic Aneurysm Formation with Bicuspid Aortic Valves

(2015) Asad A Shah   HEART SURGERY FORUM

Diagnostic Exome Sequencing Identifies a Novel Gene,EMILIN1, Associated with Autosomal-Dominant Hereditary Connective Tissue Disease

(2015) Alessandra Capuano et al.   HUMAN MUTATION

Performant Mutation Identification Using Targeted Next-Generation Sequencing of 14 Thoracic Aortic Aneurysm Genes

(2015) Dorien Proost et al.   HUMAN MUTATION

K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells

(2015) Paula Costales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections

(2015) Aida M. Bertoli-Avella et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

(2015) Boris Hinz   MATRIX BIOLOGY

Latent TGF-β-binding proteins

(2015) Ian B. Robertson et al.   MATRIX BIOLOGY

Cell Adhesion and Long-Term Survival of Transplanted Mesenchymal Stem Cells: A Prerequisite for Cell Therapy

(2015) Seahyoung Lee et al.   Oxidative Medicine and Cellular Longevity

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome

(2015) Lior Zilberberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(Tissue PET) Vascular metabolic imaging and peripheral plasma biomarkers in the evolution of chronic aortic dissections

(2015) Natzi Sakalihasan et al.   European Heart Journal-Cardiovascular Imaging

A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

(2015) Jefferson J Doyle et al.   eLife

MFAP5 Loss-of-Function Mutations Underscore the Involvement of Matrix Alteration in the Pathogenesis of Familial Thoracic Aortic Aneurysms and Dissections

(2014) Mathieu Barbier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of α1β1 Soluble Guanylate Cyclase, the Major Nitric Oxide Receptor, Leads to Moyamoya and Achalasia

(2014) Dominique Hervé et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation

(2014) Bram Trachet et al.   CARDIOVASCULAR RESEARCH

Angiogenesis and remodelling in human thoracic aortic aneurysms

(2014) Ketty Kessler et al.   CARDIOVASCULAR RESEARCH

Exome sequencing identified new mutations in a Marfan syndrome family

(2014) Guangxin Li et al.   Diagnostic Pathology

Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Endocytic Clearance of Tissue Inhibitor of Metalloproteinases-1 and Promotes Its Cytokine-Like Activities

(2014) Jessica Thevenard et al.   PLoS One

Tensegrity, cellular biophysics, and the mechanics of living systems

(2014) Donald E Ingber et al.   REPORTS ON PROGRESS IN PHYSICS

Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

(2013) Dong-chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Smad2-Dependent Protease Nexin-1 Overexpression Differentiates Chronic Aneurysms From Acute Dissections of Human Ascending Aorta

(2013) Delphine Gomez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

M1 macrophages act as LTβR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis

(2013) Kevin Guedj et al.   CARDIOVASCULAR RESEARCH

Modifications of Chromatin Dynamics Control Smad2 Pathway Activation in Aneurysmal Smooth Muscle Cells

(2013) Delphine Gomez et al.   CIRCULATION RESEARCH

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Aortic dissection in the outer third of the media: what is the role of the vasa vasorum in the triggering process?

(2013) Hiroaki Osada et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Angiotensin II Promotes Thoracic Aortic Dissections and Ruptures in Col3a1 Haploinsufficient Mice

(2013) Julie Faugeroux et al.   HYPERTENSION

Mechanical regulation of epigenetics in vascular biology and pathobiology

(2013) Li-Jing Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

(2013) Jeanette Erdmann et al.   NATURE

Thoracic aortic disease in two patients with juvenile polyposis syndrome andSMAD4mutations

(2012) Polakit Teekakirikul et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology

(2012) M.-C. Bouton et al.   BLOOD

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Neutrophil-Derived Matrix Metalloproteinase 9 Triggers Acute Aortic Dissection

(2012) Tomohiro Kurihara et al.   CIRCULATION

Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: Role of fibrillins and fibronectin

(2012) Lior Zilberberg et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Possible Mechanical Roles of Glycosaminoglycans in Thoracic Aortic Dissection and Associations with Dysregulated Transforming Growth Factor-�

(2012) J.D. Humphrey   JOURNAL OF VASCULAR RESEARCH

Polysaccharide Films Built by Simultaneous or Alternate Spray: A Rapid Way to Engineer Biomaterial Surfaces

(2012) G. Cado et al.   LANGMUIR

TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome

(2012) Catherine Boileau et al.   NATURE GENETICS

Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm

(2012) Alexander J Doyle et al.   NATURE GENETICS

Initiation of Angiogenesis in Atherosclerosis: Smooth Muscle Cells as Mediators of the Angiogenic Response to Atheroma Formation

(2012) Benoît Ho-Tin-Noé et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Faulty Initiation of Proteoglycan Synthesis Causes Cardiac and Joint Defects

(2011) Sevjidmaa Baasanjav et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1

(2011) Matthew J. Bown et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The translational science of Marfan syndrome

(2011) G. Jondeau et al.   HEART

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Mutations in Myosin Light Chain Kinase Cause Familial Aortic Dissections

(2010) Li Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms

(2010) Delphine Gomez et al.   CARDIOVASCULAR RESEARCH

Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans

(2010) J.-B. Michel et al.   CARDIOVASCULAR RESEARCH

Fibrinolytic activity is associated with presence of cystic medial degeneration in aneurysms of the ascending aorta

(2010) Luciano F Borges et al.   HISTOPATHOLOGY

TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice

(2010) Yu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

(2009) Delphine Gomez et al.   JOURNAL OF PATHOLOGY

Histopathology of an Iliac Aneurysm in a Case of Menkes Disease

(2009) Luciano de Figueiredo Borges et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Dilation-Dependent Activation of Platelets and Prothrombin in Human Thoracic Ascending Aortic Aneurysm

(2008) Ziad Touat et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Discovery of the Role of Wall Shear in Atherosclerosis

(2008) C.G. Caro   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tissue diffusion and retention of metalloproteinases in ascending aortic aneurysms and dissections

(2008) Luciano F. Borges et al.   HUMAN PATHOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tensegrity-based mechanosensing from macro to micro

(2008) Donald E. Ingber   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Arterial tortuosity syndrome: clinical and molecular findings in 12 newly identified families

(2007) B.L. Callewaert et al.   HUMAN MUTATION