Emerging roles of long non-coding RNA in cancer

Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion

(2018) Yu Ren et al.   Molecular Cancer

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

(2018) Wang Lai Hu et al.   NATURE CELL BIOLOGY

LncRNA NORAD contributes to colorectal cancer progression by inhibition of miR-202-5p

(2018) Jie zhang et al.   ONCOLOGY RESEARCH

High expression of long noncoding RNA NORAD indicates a poor prognosis and promotes clinical progression and metastasis in bladder cancer

(2018) Qiaqia Li et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Neat1 is a p53-inducible lincRNA essential for transformation suppression

(2017) Stephano S. Mello et al.   GENES & DEVELOPMENT

Divergent Activity of the Pseudogene PTENP1 in ER-Positive and Negative Breast Cancer

(2017) Synnøve Yndestad et al.   MOLECULAR CANCER RESEARCH

Long Noncoding RNA PVT1 Promotes EMT and Cell Proliferation and Migration Through Downregulating p21 in Pancreatic Cancer Cells

(2017) Bao-Qiang Wu et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population

(2017) Shekoufeh Hassanzarei et al.   TUMOR BIOLOGY

Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition

(2017) Ramkrishna Mitra et al.   Nature Communications

NORAD Expression Is Associated with Adverse Prognosis in Esophageal Squamous Cell Carcinoma

(2017) Xiaoliang Wu et al.   Oncology Research and Treatment

Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b

(2016) Shaorong Zhang et al.   APMIS

Knockdown of long non-coding RNA MALAT1 increases the blood–tumor barrier permeability by up-regulating miR-140

(2016) Jun Ma et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer

(2016) E. Latorre et al.   CANCER RESEARCH

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

(2016) Sungyul Lee et al.   CELL

NEAT1-containing paraspeckles: Central hubs in stress response and tumor formation

(2016) Carmen Adriaens et al.   CELL CYCLE

lincRNA-p21 inhibits invasion and metastasis of hepatocellular carcinoma through Notch signaling-induced epithelial-mesenchymal transition

(2016) Meng Jia et al.   HEPATOLOGY RESEARCH

MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines

(2016) Minoru Terashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 partners with RNA in the DNA damage response

(2016) Maite Huarte   NATURE GENETICS

An inducible long noncoding RNA amplifies DNA damage signaling

(2016) Adam M Schmitt et al.   NATURE GENETICS

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

(2016) Carmen Adriaens et al.   NATURE MEDICINE

The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition

(2016) C Battistelli et al.   ONCOGENE

NORAD: Defender of the Genome

(2016) Andrea Ventura   TRENDS IN GENETICS

The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma

(2016) Yaoyong Lu et al.   TUMOR BIOLOGY

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer

(2016) Mahdieh Jadaliha et al.   Oncotarget

Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152

(2016) Jianjian Zheng et al.   Oncotarget

Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA

(2016) Aparna Anantharaman et al.   Scientific Reports

MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells

(2016) Aurora Aiello et al.   Scientific Reports

Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation

(2015) Chiu-Ling Chen et al.   BIOMATERIALS

Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21

(2015) Jun Zhang et al.   CANCER BIOLOGY & THERAPY

LincRNA-p21 predicts favorable clinical outcome and impairs tumorigenesis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy

(2015) Wei Peng et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Genome-wide analysis of long noncoding RNA signature in human colorectal cancer

(2015) Yao Xue et al.   GENE

Differentiation of mammary tumors and reduction in metastasis uponMalat1lncRNA loss

(2015) Gayatri Arun et al.   GENES & DEVELOPMENT

Long non-coding RNA chromogenic in situ hybridisation signal pattern correlation with breast tumour pathology

(2015) Zhouwei Zhang et al.   JOURNAL OF CLINICAL PATHOLOGY

Paradigm shifts in genomics through the FANTOM projects

(2015) Michiel de Hoon et al.   MAMMALIAN GENOME

The landscape of long noncoding RNAs in the human transcriptome

(2015) Matthew K Iyer et al.   NATURE GENETICS

Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer

(2015) XIAO-DONG YANG et al.   ONCOLOGY REPORTS

Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells

(2015) Juanjuan Zhu et al.   PLoS One

Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

(2015) Nicolas Léveillé et al.   Nature Communications

LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer

(2015) Dejie Wang et al.   Oncotarget

Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells

(2015) Chengle Zhuang et al.   Oncotarget

Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex

(2014) Q Ji et al.   BRITISH JOURNAL OF CANCER

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

A promoter-level mammalian expression atlas

(2014)   NATURE

PVT1 dependence in cancer with MYC copy-number increase

(2014) Yuen-Yi Tseng et al.   NATURE

LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway

(2014) GUANGYU WANG et al.   ONCOLOGY REPORTS

Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers

(2013) Y Takahashi et al.   BRITISH JOURNAL OF CANCER

lincRNAs: Genomics, Evolution, and Mechanisms

(2013) Igor Ulitsky et al.   CELL

Clinical Significance of Long Intergenic Noncoding RNA-p21 in Colorectal Cancer

(2013) Haiyan Zhai et al.   Clinical Colorectal Cancer

RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

(2013) Sarah Geisler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

(2012) T. Gutschner et al.   CANCER RESEARCH

Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer

(2012) Liang Ying et al.   Molecular BioSystems

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles

(2012) R. Miyagawa et al.   RNA

The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult

(2012) Bin Zhang et al.   Cell Reports

Principles for the post-GWAS functional characterization of cancer risk loci

(2011) Matthew L Freedman et al.   NATURE GENETICS

Role of p53 in Cell Death and Human Cancers

(2011) Toshinori Ozaki et al.   Cancers

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Smoke and miRrors: pseudogenes tricking miRNAs

(2010) Meifan Chen   Pigment Cell & Melanoma Research

CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes

(2009) Leonidas Benetatos et al.   LEUKEMIA RESEARCH