Gabapentin prevents synaptogenesis between sensory and spinal cord neurons induced by thrombospondin-4 acting on pre-synaptic Cav α2 δ1 subunits and involving T-type Ca2+ channels

Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons

(2017) Yuan Guo et al.   NEUROPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Central Mechanisms Mediating Thrombospondin-4-induced Pain States

(2016) John Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injury

(2016) Bin Pan et al.   PAIN

α2δ-3 Is Required for Rapid Transsynaptic Homeostatic Signaling

(2016) Tingting Wang et al.   Cell Reports

Thrombospondin-4 reduces binding affinity of [3H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed

(2016) Beatrice Lana et al.   Scientific Reports

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nerve injury-induced calcium channel alpha-2-delta-1 protein dysregulation leads to increased pre-synaptic excitatory input into deep dorsal horn neurons and neuropathic allodynia

(2015) C. Zhou et al.   EUROPEAN JOURNAL OF PAIN

Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury

(2015) Nathan D. Crosby et al.   EXPERIMENTAL NEUROLOGY

The efficacy of gabapentin/pregabalin in improving pain after tonsillectomy: A meta-analysis

(2015) Se Hwan Hwang et al.   LARYNGOSCOPE

Calcium Channel α2δ1Proteins Mediate Trigeminal Neuropathic Pain States Associated with Aberrant Excitatory Synaptogenesis

(2014) Kang-Wu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia

(2014) Bin Pan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Postoperative Pain and Long-Term Functional Outcome After Administration of Gabapentin and Pregabalin in Patients Undergoing Spinal Surgery

(2014) Gurjeet Khurana et al.   SPINE

Electrophysiological characterization of spinal neuron sensitization by elevated calcium channel alpha-2-delta-1 subunit protein

(2013) C. Zhou et al.   EUROPEAN JOURNAL OF PAIN

Trigeminal nerve injury-induced thrombospondin-4 up-regulation contributes to orofacial neuropathic pain states in a rat model

(2013) K.-W. Li et al.   EUROPEAN JOURNAL OF PAIN

Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling

(2013) Slobodan M. Todorovic et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The α2δ subunits of voltage-gated calcium channels

(2012) Annette C. Dolphin   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Thrombospondin-4 Contributes to Spinal Sensitization and Neuropathic Pain States

(2012) D.-S. Kim et al.   JOURNAL OF NEUROSCIENCE

Presynaptic CaV3.2 Channels Regulate Excitatory Neurotransmission in Nociceptive Dorsal Horn Neurons

(2012) M. O. Jacus et al.   JOURNAL OF NEUROSCIENCE

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

(2012) Annette C. Dolphin   NATURE REVIEWS NEUROSCIENCE

Generation and Characterization of an Advillin-Cre Driver Mouse Line

(2011) Sandra Zurborg et al.   Molecular Pain

Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states

(2011) Amin Boroujerdi et al.   PAIN

The Thrombospondins

(2011) J. C. Adams et al.   Cold Spring Harbor Perspectives in Biology

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

An in vitro assay system for studying synapse formation between nociceptive dorsal root ganglion and dorsal horn neurons

(2010) Donald J. Joseph et al.   JOURNAL OF NEUROSCIENCE METHODS

The  2  subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function

(2010) A. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Enhanced Pre-Synaptic Glutamate Release in Deep-Dorsal Horn Contributes to Calcium Channel Alpha-2-Delta-1 Protein-Mediated Spinal Sensitization and Behavioral Hypersensitivity

(2009) David Nguyen et al.   Molecular Pain

Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1

(2009) Junyu Xu et al.   NATURE NEUROSCIENCE

Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acetic protein in maintenance of pain behaviors

(2009) Doo-sik Kim et al.   PAIN

Review of the use of Gabapentin in the Control of Postoperative Pain

(2009) Jefferson Clivatti et al.   Revista Brasileira de Anestesiologia

Gabapentin Attenuates Late but Not Early Postoperative Pain After Thyroidectomy with Superficial Cervical Plexus Block

(2008) Nicolas Brogly et al.   ANESTHESIA AND ANALGESIA

Effect of cytokines on neuronal excitability

(2008) Maria Schäfers et al.   NEUROSCIENCE LETTERS

Gabapentin in traumatic nerve injury pain: A randomized, double-blind, placebo-controlled, cross-over, multi-center study

(2008) Torsten E. Gordh et al.   PAIN

Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain

(2008) Amin Boroujerdi et al.   PAIN

Preparation and Maintenance of Dorsal Root Ganglia Neurons in Compartmented Cultures

(2008) Maria F. Pazyra-Murphy et al.   Jove-Journal of Visualized Experiments