Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

Title

Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

Authors

Keywords

Kelch-like ECH-associated protein 1 (KEAP1), Nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2 or NRF2), Reactive cysteine residue, Triterpenoid antioxidant inflammation modulator (tpAIM), Synthetic antioxidant inflammation modulator AIM (sAIM), X-ray crystallography

Journal

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Volume 1860, Issue 11, Pages 2537-2552

Publisher

Elsevier BV

Online

2016-07-29

DOI

10.1016/j.bbagen.2016.07.026