Multispecies activity screening of microcin J25 mutants yields antimicrobials with increased specificity toward pathogenic Salmonella species relative to human commensal Escherichia coli

The antibiotic resistance crisis, with a focus on the United States

(2017) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Free Energy Calculations of Microcin J25 Variants Binding to the FhuA Receptor

(2017) Pin-Kuang Lai et al.   Journal of Chemical Theory and Computation

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

(2017) In Young Hwang et al.   Nature Communications

Antimicrobial Probiotics Reduce Salmonella enterica in Turkey Gastrointestinal Tracts

(2017) Brittany Forkus et al.   Scientific Reports

Lasso Peptides: An Intriguing Class of Bacterial Natural Products

(2015) Julian D. Hegemann et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chloride-Inducible Expression Vector for Delivery of Antimicrobial Peptides Targeting Antibiotic-Resistant Enterococcus faecium

(2015) Kathryn Geldart et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enterocin A mutants identified by saturation mutagenesis enhance potency towards vancomycin-resistantEnterococci

(2015) Maria K. McClintock et al.   BIOTECHNOLOGY AND BIOENGINEERING

Global trends in antimicrobial use in food animals

(2015) Thomas P. Van Boeckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accuracy-rate tradeoffs: how do enzymes meet demands of selectivity and catalytic efficiency?

(2014) Dan S Tawfik   CURRENT OPINION IN CHEMICAL BIOLOGY

Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides

(2014) Indran Mathavan et al.   Nature Chemical Biology

Modified Lactic Acid Bacteria Detect and Inhibit Multiresistant Enterococci

(2014) Juan Borrero et al.   ACS Synthetic Biology

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Translation rate is controlled by coupled trade-offs between site accessibility, selective RNA unfolding and sliding at upstream standby sites

(2013) Amin Espah Borujeni et al.   NUCLEIC ACIDS RESEARCH

Saturation Mutagenesis of Lysine 12 Leads to the Identification of Derivatives of Nisin A with Enhanced Antimicrobial Activity

(2013) Evelyn M. Molloy et al.   PLoS One

Intensive Mutagenesis of the Nisin Hinge Leads to the Rational Design of Enhanced Derivatives

(2013) Brian Healy et al.   PLoS One

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

(2013) Caitriona M. Guinane et al.   Therapeutic Advances in Gastroenterology

Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity

(2013) Des Field et al.   Microbial Biotechnology

Generation of an actagardine A variant library through saturation mutagenesis

(2012) Steven Boakes et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Sequence Determinants Governing the Topology and Biological Activity of a Lasso Peptide, Microcin J25

(2012) Rémi Ducasse et al.   CHEMBIOCHEM

Dissecting the Maturation Steps of the Lasso Peptide Microcin J25 in vitro

(2012) Kok-Phen Yan et al.   CHEMBIOCHEM

Lasso peptides: structure, function, biosynthesis, and engineering

(2012) Mikhail O. Maksimov et al.   NATURAL PRODUCT REPORTS

Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist

(2011) Thomas A. Knappe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutational Analysis of Residues in the Helical Region of the Class IIa Bacteriocin Pediocin PA-1

(2011) Helén Sophie Haugen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sequence Diversity in the Lasso Peptide Framework: Discovery of Functional Microcin J25 Variants with Multiple Amino Acid Substitutions

(2011) Si Jia Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of Antimicrobial Activity of New Mastoparan Derivatives Using QSAR and Computational Mutagenesis

(2010) Speranta Avram et al.   International Journal of Peptide Research and Therapeutics

Computational design of the lasso peptide antibiotic microcin J25

(2010) S. J. Pan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Potential Applicability of Chymotrypsin-Susceptible Microcin J25 Derivatives to Food Preservation

(2009) M. F. Pomares et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Engineered gene clusters for the production of the antimicrobial peptide microcin J25

(2009) Si Jia Pan et al.   PROTEIN EXPRESSION AND PURIFICATION

Systematic Structure-Activity Analysis of Microcin J25

(2008) Olga Pavlova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY