Regulation of LRRK2: insights from structural and biochemical analysis

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

(2017) Egon Deyaert et al.   Nature Communications

The discovery ofLRRK2p.R1441S, a novel mutation for Parkinson's disease, adds to the complexity of a mutational hotspot

(2016) Ignacio F. Mata et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Rabs, Membrane Dynamics, and Parkinson's Disease

(2016) Bor Luen Tang   JOURNAL OF CELLULAR PHYSIOLOGY

Revisiting the Roco G-protein cycle

(2015) Susanne Terheyden et al.   BIOCHEMICAL JOURNAL

The Parkinson Disease-linked LRRK2 Protein Mutation I2020T Stabilizes an Active State Conformation Leading to Increased Kinase Activity

(2014) Soumya Ray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Number and Brightness Analysis of LRRK2 Oligomerization in Live Cells

(2012) Nicholas G. James et al.   BIOPHYSICAL JOURNAL

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

(2012) Daniel C. Berwick et al.   HUMAN MOLECULAR GENETICS

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

(2012) Tatiana D. Papkovskaia et al.   HUMAN MOLECULAR GENETICS

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

(2012) B. K. Gilsbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

(2011) Alfred Wittinghofer et al.   Annual Review of Biochemistry

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

(2011) Jean-Marc Taymans et al.   PLoS One

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation

(2010) Zdenek Berger et al.   BIOCHEMISTRY

Characterization of the Roco Protein Family in Dictyostelium discoideum

(2010) Wouter N. van Egmond et al.   EUKARYOTIC CELL

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

A comparative study of Lrrk2 function in primary neuronal cultures

(2010) Justus C. Dächsel et al.   PARKINSONISM & RELATED DISORDERS

Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity

(2009) Laurie J. Reichling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

It takes two to tango: regulation of G proteins by dimerization

(2009) Raphael Gasper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

(2008) Katja Gotthardt et al.   EMBO JOURNAL

The Roco protein family: a functional perspective

(2008) Ignacio Marín et al.   FASEB JOURNAL

Investigation of leucine-rich repeat kinase 2

(2008) Vasanti S. Anand et al.   FEBS Journal