The Parkinson Disease-linked LRRK2 Protein Mutation I2020T Stabilizes an Active State Conformation Leading to Increased Kinase Activity
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Parkinson Disease-linked LRRK2 Protein Mutation I2020T Stabilizes an Active State Conformation Leading to Increased Kinase Activity
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 19, Pages 13042-13053
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2014-04-03
DOI
10.1074/jbc.m113.537811
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
- (2013) Rachel M. Bailey et al. ACTA NEUROPATHOLOGICA
- Type II Kinase Inhibitors Show an Unexpected Inhibition Mode against Parkinson’s Disease-Linked LRRK2 Mutant G2019S
- (2013) Min Liu et al. BIOCHEMISTRY
- Development of ‘DFG-out’ inhibitors of gatekeeper mutant kinases
- (2012) Hwan Geun Choi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Current understanding of LRRK2 in Parkinson’s disease: biochemical and structural features and inhibitor design
- (2012) Soumya Ray et al. Future Medicinal Chemistry
- LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
- (2012) Fumitaka Kawakami et al. PLoS One
- Sampling protein motion and solvent effect during ligand binding
- (2012) V. Limongelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
- (2012) B. K. Gilsbach et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- Kinetic, Mechanistic, and Structural Modeling Studies of Truncated Wild-Type Leucine-Rich Repeat Kinase 2 and the G2019S Mutant
- (2011) Min Liu et al. BIOCHEMISTRY
- Effect of Urea on the β-Hairpin Conformational Ensemble and Protein Denaturation Mechanism
- (2011) Anna Berteotti et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
- (2010) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Kinetic Mechanistic Studies of Wild-Type Leucine-Rich Repeat Kinase2: Characterization of the Kinase and GTPase Activities
- (2010) Min Liu et al. BIOCHEMISTRY
- Linking Well-Tempered Metadynamics Simulations with Experiments
- (2010) Alessandro Barducci et al. BIOPHYSICAL JOURNAL
- Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance
- (2010) Tianjun Zhou et al. Chemical Biology & Drug Design
- Non-ATP Competitive Protein Kinase Inhibitors
- (2010) L. Garuti et al. CURRENT MEDICINAL CHEMISTRY
- Targeting biomolecular flexibility with metadynamics
- (2010) Vanessa Leone et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Enhanced Sampling in the Well-Tempered Ensemble
- (2010) M. Bonomi et al. PHYSICAL REVIEW LETTERS
- Multiple Routes and Milestones in the Folding of HIV–1 Protease Monomer
- (2010) Massimiliano Bonomi et al. PLoS One
- Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition
- (2010) V. Limongelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
- (2010) Yulan Xiong et al. PLoS Genetics
- I2020T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson’s disease, has a higher intracellular degradation rate than the wild-type molecule
- (2009) Etsuro Ohta et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity
- (2009) Laurie J. Reichling et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro
- (2009) Christian Johannes Gloeckner et al. JOURNAL OF NEUROCHEMISTRY
- Investigation of leucine-rich repeat kinase 2
- (2008) Vasanti S. Anand et al. FEBS Journal
- Well-Tempered Metadynamics: A Smoothly Converging and Tunable Free-Energy Method
- (2008) Alessandro Barducci et al. PHYSICAL REVIEW LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More