Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
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Title
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 26, Pages 10322-10327
Publisher
Proceedings of the National Academy of Sciences
Online
2012-06-12
DOI
10.1073/pnas.1203223109
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Note: Only part of the references are listed.- The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton
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- Characterization of the Roco Protein Family in Dictyostelium discoideum
- (2010) Wouter N. van Egmond et al. EUKARYOTIC CELL
- Parkinson's disease: insights from pathways
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- Reevaluation of Phosphorylation Sites in the Parkinson Disease-associated Leucine-rich Repeat Kinase 2
- (2010) Xiaojie Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- Protein kinases: evolution of dynamic regulatory proteins
- (2010) Susan S. Taylor et al. TRENDS IN BIOCHEMICAL SCIENCES
- Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis
- (2009) Etsuro Ohta et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
- (2009) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- LRRK2 in Parkinson’s disease: biochemical functions
- (2009) Vasanti S. Anand et al. FEBS Journal
- It takes two to tango: regulation of G proteins by dimerization
- (2009) Raphael Gasper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
- (2008) Katja Gotthardt et al. EMBO JOURNAL
- Investigation of leucine-rich repeat kinase 2
- (2008) Vasanti S. Anand et al. FEBS Journal
- Intramolecular Activation Mechanism of theDictyosteliumLRRK2 Homolog Roco Protein GbpC
- (2008) Wouter N. van Egmond et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
- (2008) Elisa Greggio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
- (2008) J. Deng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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