Leucine supplementation attenuates macrophage foam-cell formation: Studies in humans, mice, and cultured macrophages

Atherogenicity of amino acids in the lipid-laden macrophage model system in vitro and in atherosclerotic mice: a key role for triglyceride metabolism

(2017) Oren Rom et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner

(2016) Mahshid Moghei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acrolein increases macrophage atherogenicity in association with gut microbiota remodeling in atherosclerotic mice: protective role for the polyphenol-rich pomegranate juice

(2016) Oren Rom et al.   ARCHIVES OF TOXICOLOGY

Supplementation with linoleic acid-rich soybean oil stimulates macrophage foam cell formation via increased oxidative stress and diacylglycerol acyltransferase1-mediated triglyceride biosynthesis

(2016) Oren Rom et al.   BIOFACTORS

Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial

(2016) M. Ruiz-Canela et al.   CLINICAL CHEMISTRY

The relationship of endogenous plasma concentrations of β-Hydroxy β-Methyl Butyrate (HMB) to age and total appendicular lean mass in humans

(2016) Rebecca Kuriyan et al.   EXPERIMENTAL GERONTOLOGY

Associations between branched chain amino acid intake and biomarkers of adiposity and cardiometabolic health independent of genetic factors: A twin study

(2016) Amy Jennings et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pomegranate Juice Polyphenols Induce Macrophage Death via Apoptosis as Opposed to Necrosis Induced by Free Radical Generation

(2016) Oren Rom et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia–reperfusion injury

(2016) Weibing Dong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Aqueous or lipid components of atherosclerotic lesion increase macrophage oxidation and lipid accumulation

(2016) Niroz Abu-Saleh et al.   LIFE SCIENCES

Nitro-Oleic Acid Reduces J774A.1 Macrophage Oxidative Status and Triglyceride Mass: Involvement of Paraoxonase2 and Triglyceride Metabolizing Enzymes

(2016) Mira Rosenblat et al.   LIPIDS

Leucine in Obesity: Therapeutic Prospects

(2016) Kang Yao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice

(2015) Yang Zhao et al.   ACTA PHARMACOLOGICA SINICA

Leucine-induced anabolic-catabolism: two sides of the same coin

(2015) Nicholas P. Gannon et al.   AMINO ACIDS

Leucine restores murine hepatic triglyceride accumulation induced by a low-protein diet by suppressing autophagy and excessive endoplasmic reticulum stress

(2015) Shin-Ichi Yokota et al.   AMINO ACIDS

Sulfur amino acids and atherosclerosis: a role for excess dietary methionine

(2015) Jacob Selhub et al.   Annals of the New York Academy of Sciences

Foamy Monocytes Form Early and Contribute to Nascent Atherosclerosis in Mice With HypercholesterolemiaSignificance

(2015) Lu Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in AtherosclerosisNovelty and Significance

(2015) Denuja Karunakaran et al.   CIRCULATION RESEARCH

High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE−/−mice

(2015) An-Ning Yang et al.   FEBS LETTERS

Amino Acid Intakes Are Inversely Associated with Arterial Stiffness and Central Blood Pressure in Women

(2015) Amy Jennings et al.   JOURNAL OF NUTRITION

Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats

(2015) Yohei Tanada et al.   LIFE SCIENCES

Plasma Free Amino Acid Profiles Predict Four-Year Risk of Developing Diabetes, Metabolic Syndrome, Dyslipidemia and Hypertension in Japanese Population

(2015) Minoru Yamakado et al.   Scientific Reports

Blood Serum Atherogenicity and Coronary Artery Calcification

(2014) Igor Sobenin et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Mechanisms of Cellular Cholesterol Efflux

(2014) Michael C. Phillips   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Branched-Chain Amino Acids with Carotid Intima-Media Thickness and Coronary Artery Disease Risk Factors

(2014) Ruiyue Yang et al.   PLoS One

Effects of Leucine Supplementation and Serum Withdrawal on Branched-Chain Amino Acid Pathway Gene and Protein Expression in Mouse Adipocytes

(2014) Abderrazak Kitsy et al.   PLoS One

Branched-chain Amino Acid Intake and the Risk of Diabetes in a Japanese Community: The Takayama Study

(2013) C. Nagata et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Pomegranate extract (POMx) decreases the atherogenicity of serum and of human monocyte-derived macrophages (HMDM) in simvastatin-treated hypercholesterolemic patients: A double-blinded, placebo-controlled, randomized, prospective pilot study

(2013) Shadi Hamoud et al.   ATHEROSCLEROSIS

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

The effect of hyperhomocysteinemia on aortic distensibility in healthy individuals

(2013) Ioanna Eleftheriadou et al.   NUTRITION

Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans

(2012) Fanny Theytaz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis

(2012) P. Wurtz et al.   EUROPEAN HEART JOURNAL

Mechanisms of triglyceride accumulation in activated macrophages

(2012) Kenneth R. Feingold et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A high leucine diet mitigates cardiac injury and improves survival after acute myocardial infarction

(2012) William G. Witham et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Triglycerides and Heart Disease

(2011) Ira J. Goldberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin increases macrophage triglyceride accumulation under diabetic conditions through the down regulation of hormone sensitive lipase and adipose triglyceride lipase

(2011) Edna Meilin et al.   BIOFACTORS

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

(2010) Svati H. Shah et al.   Circulation-Cardiovascular Genetics

Higher Branched-Chain Amino Acid Intake Is Associated with a Lower Prevalence of Being Overweight or Obese in Middle-Aged East Asian and Western Adults

(2010) Li‐Qiang Qin et al.   JOURNAL OF NUTRITION

Ketogenic Essential Amino Acids Modulate Lipid Synthetic Pathways and Prevent Hepatic Steatosis in Mice

(2010) Yasushi Noguchi et al.   PLoS One

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the STEATO Study

(2009) Claudio Carallo et al.   JOURNAL OF GASTROENTEROLOGY

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH