Spotlight on the transglutaminase 2 gene: a focus on genomic and transcriptional aspects

A long non-coding RNA inside the type 2 transglutaminase gene tightly correlates with the expression of its transcriptional variants

(2018) Linda Minotti et al.   AMINO ACIDS

Transglutaminases in autoimmune and inherited skin diseases: The phenomena of epitope spreading and functional compensation

(2018) Sarolta Kárpáti et al.   EXPERIMENTAL DERMATOLOGY

Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction

(2018) Giulia Furini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tissue transglutaminase TG2 and mitochondrial function and dysfunction

(2017) Thung-S. Lai   Frontiers in Bioscience-Landmark

MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer

(2017) Meng Xie et al.   Gastric Cancer

MicroRNA-206 prevents the pathogenesis of hepatocellular carcinoma by modulating expression of met proto-oncogene and cyclin-dependent kinase 6 in mice

(2017) Heng Wu et al.   HEPATOLOGY

MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis

(2017) Heng Wu et al.   JOURNAL OF HEPATOLOGY

Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia

(2017) Sara Zonca et al.   Cell Death & Disease

IGF-1 may predict the severity and outcome of patients with sepsis and be associated with microRNA-1 level changes

(2017) Liang Xu et al.   Experimental and Therapeutic Medicine

MicroRNA-613 inhibits the progression of gastric cancer by targeting CDK9

(2017) Yebin Lu et al.   Artificial Cells Nanomedicine and Biotechnology

Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2

(2017) Kiruphagaran Thangaraju et al.   PLoS One

Role of tissue transglutaminase-2 (TG2)-mediated aminylation in biological processes

(2016) Thung-S. Lai et al.   AMINO ACIDS

Computational analyses of the effect of novel amino acid clusters of human transglutaminase 2 on its structure and function

(2016) Kiruphagaran Thangaraju et al.   AMINO ACIDS

Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target

(2016) Navneet Agnihotri et al.   AMINO ACIDS

Transcriptional control of transglutaminase 2 expression in mouse apoptotic thymocytes

(2016) Katalin Sándor et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

IL-1β induces IL-6 production and increases invasiveness and estrogen-independent growth in a TG2-dependent manner in human breast cancer cells

(2016) Keunhee Oh et al.   BMC CANCER

Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer

(2016) Cheng-Gong Hou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hydrogen Sulfide Protects Cardiomyocytes against Apoptosis in Ischemia/Reperfusion through MiR-1-Regulated Histone Deacetylase 4 Pathway

(2016) Bo Kang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C-terminal beta-barrel domain

(2016) Jorunn Stamnaes et al.   FEBS Journal

Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival

(2016) C Kerr et al.   ONCOGENE

Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death

(2016) H Tatsukawa et al.   Cell Death & Disease

MiR-206 Suppresses the Progression of Coronary Artery Disease by Modulating Vascular Endothelial Growth Factor (VEGF) Expression

(2016) Maojing Wang et al.   MEDICAL SCIENCE MONITOR

miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer

(2015) D. Cellura et al.   MOLECULAR CANCER RESEARCH

MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS

(2015) Xin Fu et al.   TUMOR BIOLOGY

Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells

(2015) R Shrestha et al.   Cell Death & Disease

Silencing of TGM2 reverses epithelial to mesenchymal transition and modulates the chemosensitivity of breast cancer to docetaxel

(2015) WENXING HE et al.   Experimental and Therapeutic Medicine

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma

(2015) Hideo Hidaka et al.   Oncotarget

miR-613 regulates cholesterol efflux by targeting LXRα and ABCA1 in PPARγ activated THP-1 macrophages

(2014) Ranzun Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

(2014) B. Daniel et al.   GENES & DEVELOPMENT

A Novel Mechanism by Which Tissue Transglutaminase Activates Signaling Events That Promote Cell Survival

(2014) Lindsey K. Boroughs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transglutaminase II/MicroRNA-218/-181a Loop Regulates Positive Feedback Relationship between Allergic Inflammation and Tumor Metastasis

(2014) Sangkyung Eom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange

(2014) Rasmus Iversen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGM2 and implications for human disease: role of alternative splicing 

(2013) Charles Greenberg   Frontiers in Bioscience-Landmark

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

(2013) Yangyang Bian et al.   Journal of Proteomics

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent

(2013) Siiri E. Iismaa et al.   PLoS One

Detection of Transglutaminase 2 conformational changes in living cell

(2012) Marat S. Pavlyukov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transglutaminase 2 and NF-κB: an odd couple that shapes breast cancer phenotype

(2012) Kevin D. Brown   BREAST CANCER RESEARCH AND TREATMENT

Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis

(2012) Soichi Kojima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Tissue Transglutaminase Constitutively Activates HIF-1α Promoter and Nuclear Factor-κB via a Non-Canonical Pathway

(2012) Santosh Kumar et al.   PLoS One

Polymorphism of transglutaminase 2: unusually low frequency of genomic variants with deficient functions

(2011) Róbert Király et al.   AMINO ACIDS

Expression of transglutaminase-2 isoforms in normal human tissues and cancer cell lines: dysregulation of alternative splicing in cancer

(2011) V. M. Phatak et al.   AMINO ACIDS

TG2, a novel extracellular protein with multiple functions

(2011) Zhuo Wang et al.   AMINO ACIDS

Transglutaminase 2: A molecular Swiss army knife

(2011) Soner Gundemir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein transamidation by transglutaminase 2 in cells: a disputed Ca2+-dependent action of a multifunctional protein

(2011) Róbert Király et al.   FEBS Journal

Extracellular TG2: emerging functions and regulation

(2011) Alexey M. Belkin   FEBS Journal

A Crucial Sequence for Transglutaminase Type 2 Extracellular Trafficking in Renal Tubular Epithelial Cells Lies in Its N-terminal β-Sandwich Domain

(2011) Che-Yi Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Extracellular Transglutaminase 2 by Thioredoxin

(2011) Xi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects

(2011) Z. Simon-Vecsei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-specific estrogen receptor   deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

(2011) V. Ribas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Regulation of Transglutaminase 2 Activity

(2010) Jorunn Stamnaes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transglutaminase 2 gene is aberrantly hypermethylated in glioma

(2010) Lisa M. Dyer et al.   JOURNAL OF NEURO-ONCOLOGY

The functional significance of the TGM2 gene in schizophrenia: A correlation of SNPs and circulating IL-2 levels

(2010) Matilda Bradford et al.   JOURNAL OF NEUROIMMUNOLOGY

Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy?

(2010) Linghong Huang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The TGM2 gene is associated with schizophrenia in a British population

(2009) Matilda Bradford et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Epithelial-to-Mesenchymal Transition and Ovarian Tumor Progression Induced by Tissue Transglutaminase

(2009) M. Shao et al.   CANCER RESEARCH

Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages

(2009) Cédric Rébé et al.   CIRCULATION RESEARCH

Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation

(2009) Andrew E. L. Tee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperonin overexpression promotes genetic variation and enzyme evolution

(2009) Nobuhiko Tokuriki et al.   NATURE

An overview of the first 50 years of transglutaminase research

(2008) Simone Beninati et al.   AMINO ACIDS

Clinical and Biological Significance of Tissue Transglutaminase in Ovarian Carcinoma

(2008) J. Y. Hwang et al.   CANCER RESEARCH

The transglutaminase 2 gene ( TGM2 ), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer

(2008) Lingbao Ai et al.   CARCINOGENESIS

Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

(2008) Matthew Siegel et al.   PLoS One