Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death

Physiological, pathological, and structural implications of non-enzymatic protein–protein interactions of the multifunctional human transglutaminase 2

(2015) Kajal Kanchan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of Smad7 and Smad ubiquitin regulatory factor 2 in a rat model of chronic pancreatitis

(2015) Xiao Jia Hou et al.   Journal of Digestive Diseases

The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF165-induced angiogenesis

(2015) Nathan Beckouche et al.   Science Signaling

Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells

(2015) R Shrestha et al.   Cell Death & Disease

The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF165-induced angiogenesis

(2015) Nathan Beckouche et al.   Science Signaling

Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast

(2014) Hilary Grosso et al.   FASEB JOURNAL

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

Potential New Mechanisms of Placental Damage in Celiac Disease: Anti-Transglutaminase Antibodies Impair Human Endometrial Angiogenesis1

(2013) Nicoletta Di Simone et al.   BIOLOGY OF REPRODUCTION

Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2

(2013) Cristina Antonella Nadalutti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tissue transglutaminase is not a biochemical marker for Alzheimer's disease

(2013) Johannes Wolf et al.   NEUROBIOLOGY OF AGING

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent

(2013) Siiri E. Iismaa et al.   PLoS One

A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

(2013) Z Wang et al.   Cell Death & Disease

A Mechanism for the Upregulation of EGF Receptor Levels in Glioblastomas

(2013) Jingwen Zhang et al.   Cell Reports

Polymorphism of transglutaminase 2: unusually low frequency of genomic variants with deficient functions

(2011) Róbert Király et al.   AMINO ACIDS

Induction of Cross-Linking and Silencing of Sp1 by Transglutaminase during Liver Injury in ASH and NASH via Different ER Stress Pathways

(2011) Soichi Kojima et al.   DIGESTIVE DISEASES

Protein transamidation by transglutaminase 2 in cells: a disputed Ca2+-dependent action of a multifunctional protein

(2011) Róbert Király et al.   FEBS Journal

Extracellular TG2: emerging functions and regulation

(2011) Alexey M. Belkin   FEBS Journal

Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

(2011) Yury Popov et al.   GASTROENTEROLOGY

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

(2011) Lise Munsie et al.   HUMAN MOLECULAR GENETICS

Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways

(2011) Ting-Fang Kuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice

(2011) Keunhee Oh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells

(2011) Hideki Tatsukawa et al.   Molecular Cancer

Targeting Ovarian Tumor Cell Adhesion Mediated by Tissue Transglutaminase

(2011) M. Khanna et al.   MOLECULAR CANCER THERAPEUTICS

Complete transglutaminase 2 ablation results in reduced stroke volumes and astrocytes that exhibit increased survival in response to ischemia

(2011) Gozde Colak et al.   NEUROBIOLOGY OF DISEASE

Brain infarction correlates more closely with acrolein than with reactive oxygen species

(2010) Ryotaro Saiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells

(2010) Clément Faye et al.   BIOCHEMICAL JOURNAL

Transglutaminase 2: A multi-tasking protein in the complex circuitry of inflammation and cancer

(2010) Kapil Mehta et al.   BIOCHEMICAL PHARMACOLOGY

Tissue transglutaminase contributes to the all-trans-retinoic acid-induced differentiation syndrome phenotype in the NB4 model of acute promyelocytic leukemia

(2010) K. Csomos et al.   BLOOD

Recent advances in understanding the roles of transglutaminase 2 in alcoholic steatohepatitis

(2010) Hideki Tatsukawa et al.   CELL BIOLOGY INTERNATIONAL

Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness

(2010) Lakshmi Santhanam et al.   CIRCULATION RESEARCH

Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesis

(2010) E. Myrsky et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Déjà vuwith a twist: transglutaminases in bioenergetics and transcriptional dysfunction in Huntington's disease

(2010) Parsa Kazemi-Esfarjani et al.   EMBO Molecular Medicine

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

(2010) Stephen J. McConoughey et al.   EMBO Molecular Medicine

Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase−fibronectin complex

(2010) Z. Wang et al.   EXPERIMENTAL CELL RESEARCH

RGD-independent Cell Adhesion via a Tissue Transglutaminase-Fibronectin Matrix Promotes Fibronectin Fibril Deposition and Requires Syndecan-4/2 and α5β1 Integrin Co-signaling

(2010) Zhuo Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymerization of insulin-like growth factor-binding protein-1 (IGFBP-1) potentiates IGF-I actions in placenta

(2010) Hiromi Shibuya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Type 2 transglutaminase in Huntington’s disease: a double-edged sword with clinical potential

(2010) P. G. Mastroberardino et al.   JOURNAL OF INTERNAL MEDICINE

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Transglutaminase 2 protects against ischemic stroke

(2010) A.J. Filiano et al.   NEUROBIOLOGY OF DISEASE

Transglutaminase 2 expression induced by lipopolysaccharide stimulation together with NO synthase induction in cultured astrocytes

(2010) K. Takano et al.   NEUROCHEMISTRY INTERNATIONAL

NF-κB addiction and its role in cancer: ‘one size does not fit all’

(2010) M M Chaturvedi et al.   ONCOGENE

Transglutaminase 2 is involved in autophagosome maturation

(2009) Manuela D'Eletto et al.   Autophagy

Expression of tissue-type transglutaminase (tTG) and the effect of tTG inhibitor on the hippocampal CA1 region after transient ischemia in gerbils

(2009) In Koo Hwang et al.   BRAIN RESEARCH

The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis

(2009) W Malorni et al.   CELL DEATH AND DIFFERENTIATION

Garlic extract prevents CCl4-induced liver fibrosis in rats: The role of tissue transglutaminase

(2009) Giuseppe D’Argenio et al.   DIGESTIVE AND LIVER DISEASE

Increase in transglutaminase 2 expression is associated with NF-kappaB activation in breast cancer tissues

(2009) Kang-Seo Park   Frontiers in Bioscience-Landmark

Role of Transglutaminase 2 in Liver Injury via Cross-linking and Silencing of Transcription Factor Sp1

(2009) Hideki Tatsukawa et al.   GASTROENTEROLOGY

c-Met Confers Protection Against Chronic Liver Tissue Damage and Fibrosis Progression After Bile Duct Ligation in Mice

(2009) Arne Giebeler et al.   GASTROENTEROLOGY

Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation

(2009) Andrew E. L. Tee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The First Draft of the Endostatin Interaction Network

(2009) Clément Faye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased TG2 Expression Can Result in Induction of Transforming Growth Factor β1, Causing Increased Synthesis and Deposition of Matrix Proteins, Which Can Be Regulated by Nitric Oxide

(2009) Dilek Telci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation

(2009) A. Luciani et al.   JOURNAL OF IMMUNOLOGY

Transglutaminase 2 Is Needed for the Formation of an Efficient Phagocyte Portal in Macrophages Engulfing Apoptotic Cells

(2009) B. Toth et al.   JOURNAL OF IMMUNOLOGY

Transglutaminases and neurodegeneration

(2009) Thomas M. Jeitner et al.   JOURNAL OF NEUROCHEMISTRY

Transglutaminases and Disease: Lessons From Genetically Engineered Mouse Models and Inherited Disorders

(2009) Siiri E. Iismaa et al.   PHYSIOLOGICAL REVIEWS

Intracellular Localization and Conformational State of Transglutaminase 2: Implications for Cell Death

(2009) Soner Gundemir et al.   PLoS One

Tissue Transglutaminase Contributes to Interstitial Renal Fibrosis by Favoring Accumulation of Fibrillar Collagen through TGF-β Activation and Cell Infiltration

(2008) Nasim Shweke et al.   AMERICAN JOURNAL OF PATHOLOGY

Homocysteine-induced toxicity increases TG2 expression in Neuro2a cells

(2008) M. Currò et al.   AMINO ACIDS

Transglutaminase 2 protects against ischemic insult, interacts with HIF1β, and attenuates HIF1 signaling

(2008) Anthony J. Filiano et al.   FASEB JOURNAL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

A New Regulatory Mechanism of NF-κB Activation by I-κBβ in Cancer Cells

(2008) Jung Mo Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

NF-κB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis

(2008) Ching-Shyang Chen et al.   TOXICOLOGY

Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice

(2007) Tsai-Ching Hsu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY