Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival

Survival of skin cancer stem cells requires the Ezh2 polycomb group protein

(2015) Gautam Adhikary et al.   CARCINOGENESIS

Transglutaminase Is Required for Epidermal Squamous Cell Carcinoma Stem Cell Survival

(2015) M. L. Fisher et al.   MOLECULAR CANCER RESEARCH

Transglutaminase is a tumor cell and cancer stem cell survival factor

(2015) Richard L. Eckert et al.   MOLECULAR CARCINOGENESIS

Inhibitors of tissue transglutaminase

(2015) Jeffrey W. Keillor et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Type II transglutaminase stimulates epidermal cancer stem cell epithelial-mesenchymal transition

(2015) Matthew L. Fisher et al.   Oncotarget

Acyl transfer mechanisms of tissue transglutaminase

(2014) Jeffrey W. Keillor et al.   BIOORGANIC CHEMISTRY

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

Crystal Structure of Transglutaminase 2 with GTP Complex and Amino Acid Sequence Evidence of Evolution of GTP Binding Site

(2014) Tae-Ho Jang et al.   PLoS One

TGM2 inhibition attenuates ID1 expression in CD44-high glioma-initiating cells

(2013) J. Fu et al.   NEURO-ONCOLOGY

Identification of a Population of Epidermal Squamous Cell Carcinoma Cells with Enhanced Potential for Tumor Formation

(2013) Gautam Adhikary et al.   PLoS One

Real-Time Monitoring of Protein Conformational Dynamics in Solution Using Kinetic Capillary Electrophoresis

(2012) Christopher M. Clouthier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Transglutaminase 2 conformational changes in living cell

(2012) Marat S. Pavlyukov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease

(2012) Michael E. Prime et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using FLIM-FRET to Measure Conformational Changes of Transglutaminase Type 2 in Live Cells

(2012) Nicholas S. Caron et al.   PLoS One

Recent advances in the development of tissue transglutaminase (TG2) inhibitors

(2011) E. Badarau et al.   AMINO ACIDS

Transglutaminase 2: A molecular Swiss army knife

(2011) Soner Gundemir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Tissue transglutaminase links TGF-β, epithelial to mesenchymal transition and a stem cell phenotype in ovarian cancer

(2011) L Cao et al.   ONCOGENE

Evidence That Aberrant Expression of Tissue Transglutaminase Promotes Stem Cell Characteristics in Mammary Epithelial Cells

(2011) Anupam Kumar et al.   PLoS One

Redox Regulation of Transglutaminase 2 Activity

(2010) Jorunn Stamnaes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue Transglutaminase Promotes Drug Resistance and Invasion by Inducing Mesenchymal Transition in Mammary Epithelial Cells

(2010) Anupam Kumar et al.   PLoS One

Photolabeling of Tissue Transglutaminase Reveals the Binding Mode of Potent Cinnamoyl Inhibitors†

(2009) Christophe Pardin et al.   BIOCHEMISTRY

Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesis

(2009) Róbert Király et al.   FEBS Journal

Intracellular Localization and Conformational State of Transglutaminase 2: Implications for Cell Death

(2009) Soner Gundemir et al.   PLoS One

Biological and therapeutic significance of tissue transglutaminase in pancreatic cancer

(2008) K. Mehta   AMINO ACIDS

TIG3: a regulator of type I transglutaminase activity in epidermis

(2008) Richard L. Eckert et al.   AMINO ACIDS

Synthesis of potent water-soluble tissue transglutaminase inhibitors

(2008) Martin Griffin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The bioorganic chemistry of transglutaminase — from mechanism to inhibition and engineering

(2008) Jeffrey W Keillor et al.   CANADIAN JOURNAL OF CHEMISTRY

Reversible and Competitive Cinnamoyl Triazole Inhibitors of Tissue Transglutaminase

(2008) Christophe Pardin et al.   Chemical Biology & Drug Design

Localization of the TIG3 Transglutaminase Interaction Domain and Demonstration that the Amino-Terminal Region Is Required for TIG3 Function as a Keratinocyte Differentiation Regulator

(2007) Ralph Jans et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY