Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms

GM1 and GD1a gangliosides modulate toxic and inflammatory effects of E. coli lipopolysaccharide by preventing TLR4 translocation into lipid rafts

(2015) Svetlana Nikolaeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids

(2015) Christopher Lipina et al.   CELLULAR SIGNALLING

Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome

(2015) Lucas Veillon et al.   PLoS One

Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3

(2014) M. Nagafuku et al.   GLYCOBIOLOGY

Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function

(2014) Maria Laura Allende et al.   GLYCOCONJUGATE JOURNAL

GM3 and diabetes

(2014) Jin-ichi Inokuchi   GLYCOCONJUGATE JOURNAL

Sialidase NEU3 Dynamically Associates to Different Membrane Domains Specifically Modifying Their Ganglioside Pattern and Triggering Akt Phosphorylation

(2014) Dario Bonardi et al.   PLoS One

Disialic, oligosialic and polysialic acids: distribution, functions and related disease

(2013) C. Sato et al.   JOURNAL OF BIOCHEMISTRY

Ceramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling

(2013) Jose A. Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate

(2013) Katherine Macrae et al.   JOURNAL OF LIPID RESEARCH

Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro

(2013) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian sialidases: Physiological and pathological roles in cellular functions

(2012) T. Miyagi et al.   GLYCOBIOLOGY

Implications for the mammalian sialidases in the physiopathology of skeletal muscle

(2012) Alessandro Fanzani et al.   Skeletal Muscle

Ceramide formation as a target in beta-cell survival and function

(2011) Florian Lang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dissociation of the insulin receptor from caveolae during TNFα-induced insulin resistance and its recovery byd-PDMP

(2011) Junji Sekimoto et al.   FEBS LETTERS

Chronic Effects of Palmitate Overload on Nutrient-Induced Insulin Secretion and Autocrine Signalling in Pancreatic MIN6 Beta Cells

(2011) Maria L. Watson et al.   PLoS One

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ganglioside GM3 and its biological functions

(2009) N. V. Prokazova et al.   BIOCHEMISTRY-MOSCOW

Membrane microdomains and insulin resistance

(2009) Jin-ichi Inokuchi   FEBS LETTERS

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice

(2009) Nora Bijl et al.   HEPATOLOGY

Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation

(2009) Marco van Eijk et al.   PLoS One

Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3

(2008) C Tringali et al.   CELL DEATH AND DIFFERENTIATION

Prominent increase in plasma ganglioside GM3 is associated with clinical manifestations of type I Gaucher disease

(2008) Karen Ghauharali-van der Vlugt et al.   CLINICA CHIMICA ACTA

Circulating levels of ganglioside GM3 in metabolic syndrome: A pilot study

(2008) Takashige Sato et al.   Obesity Research & Clinical Practice