Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function

GM3 and diabetes

(2014) Jin-ichi Inokuchi   GLYCOCONJUGATE JOURNAL

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

(2014) Ramya Lakshminarayan et al.   NATURE CELL BIOLOGY

Cutaneous dyspigmentation in patients with ganglioside GM3 synthase deficiency

(2013) Heng Wang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Ceramide synthesis in the epidermis

(2013) Mariona Rabionet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipids and lysosomal pathologies

(2013) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis

(2013) Gaurav V. Harlalka et al.   BRAIN

Glycosphingolipids: synthesis and functions

(2013) Giovanni D'Angelo et al.   FEBS Journal

Sulfatide decrease in myelin influences formation of the paranodal axo-glial junction and conduction velocity in the sciatic nerve

(2013) Akiko Hayashi et al.   GLIA

Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice

(2013) Sha Sha et al.   HIPPOCAMPUS

Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing

(2013) Nicole Amen et al.   HUMAN MOLECULAR GENETICS

Ganglioside GM3 Depletion Reverses Impaired Wound Healing in Diabetic Mice by Activating IGF-1 and Insulin Receptors

(2013) Xiao-Qi Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sulfatides are required for renal adaptation to chronic metabolic acidosis

(2013) P. Stettner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis

(2013) Viola Nordström et al.   PLOS BIOLOGY

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

(2012) Thomas A. Natoli et al.   HUMAN MOLECULAR GENETICS

Glycosphingolipids Are Essential for Intestinal Endocytic Function

(2012) Richard Jennemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of sulfatide in normal and pathological cells and tissues

(2012) Tadanobu Takahashi et al.   JOURNAL OF LIPID RESEARCH

Functional Roles of Gangliosides in Neurodevelopment: An Overview of Recent Advances

(2012) Robert K. Yu et al.   NEUROCHEMICAL RESEARCH

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Gangliosides and the multiscale modulation of membrane structure

(2011) Laura Cantù et al.   CHEMISTRY AND PHYSICS OF LIPIDS

A view on sphingolipids and disease

(2011) Thomas Kolter   CHEMISTRY AND PHYSICS OF LIPIDS

Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis

(2010) Chien-Tsun Kuan et al.   BMC DEVELOPMENTAL BIOLOGY

β4-Galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development

(2010) Toshikazu Nishie et al.   GLYCOBIOLOGY

Hepatic glycosphingolipid deficiency and liver function in mice

(2010) Richard Jennemann et al.   HEPATOLOGY

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

(2010) Thomas A Natoli et al.   NATURE MEDICINE

Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation

(2010) A. Togayachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain gangliosides in axon-myelin stability and axon regeneration

(2009) Ronald L. Schnaar   FEBS LETTERS

Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice

(2009) Laleh Saadat et al.   GLIA

Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels

(2009) Zhiqiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti

(2009) M. Yoshikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced motor and sensory functions and emotional response in GM3-only mice: Emergence from early stage of life and exacerbation with aging

(2008) Orie Tajima et al.   BEHAVIOURAL BRAIN RESEARCH

Early lethality of β-1,4-galactosyltransferase V-mutant mice by growth retardation

(2008) Tadahiro Kumagai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo

(2008) Franziska Biellmann et al.   BMC DEVELOPMENTAL BIOLOGY

The Role and Metabolism of Sulfatide in the Nervous System

(2008) Matthias Eckhardt   MOLECULAR NEUROBIOLOGY