Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells

Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles

(2016) Jie Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

(2016) Jiekun Xuan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

(2015) Yuanfeng Wu et al.   BIOCHEMICAL PHARMACOLOGY

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage

(2015) Masato Matsuoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells

(2015) Si Chen et al.   TOXICOLOGICAL SCIENCES

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

(2015) Jiangting Hu et al.   TOXICOLOGICAL SCIENCES

Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related

(2015) Kevin M. Beggs et al.   TOXICOLOGY

The ER Stress-Mediated Mitochondrial Apoptotic Pathway and MAPKs Modulate Tachypacing-Induced Apoptosis in HL-1 Atrial Myocytes

(2015) Jiaojiao Shi et al.   PLoS One

Endoplasmic Reticulum Stress in Drug- and Environmental Toxicant-Induced Liver Toxicity

(2014) Si Chen et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death

(2014) Jung Soo Kim et al.   JOURNAL OF NEURAL TRANSMISSION

Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity

(2014) Lisa Fredriksson et al.   TOXICOLOGICAL SCIENCES

The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells

(2014) Si Chen et al.   TOXICOLOGICAL SCIENCES

Sertraline induces endoplasmic reticulum stress in hepatic cells

(2014) Si Chen et al.   TOXICOLOGY

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning

(2013) Bo Gao et al.   ACTA PHARMACOLOGICA SINICA

Antidepressant-Induced Liver Injury: A Review for Clinicians

(2013) Cosmin Sebastian Voican et al.   AMERICAN JOURNAL OF PSYCHIATRY

ER stress in human hepatic cells treated with Efavirenz: Mitochondria again

(2013) Nadezda Apostolova et al.   JOURNAL OF HEPATOLOGY

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

(2013) Dotan Uzi et al.   JOURNAL OF HEPATOLOGY

Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway

(2013) Si Chen et al.   TOXICOLOGICAL SCIENCES

Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways

(2013) Tien-Hui Lu et al.   TOXICOLOGY LETTERS

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent

(2012) Yan Li et al.   TOXICOLOGICAL SCIENCES

Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity

(2012) Jae-Ah Kim et al.   TOXICOLOGY LETTERS

Development of a Highly Sensitive Cytotoxicity Assay System for CYP3A4-Mediated Metabolic Activation

(2011) H. Hosomi et al.   DRUG METABOLISM AND DISPOSITION

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1

(2011) Yan Li et al.   TOXICOLOGICAL SCIENCES

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

(2010) L. Guo et al.   DRUG METABOLISM AND DISPOSITION

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response

(2009) Sana Basseri et al.   JOURNAL OF LIPID RESEARCH

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES