Manipulation of metabolic pathways controlled by signaling molecules, inducers of antibiotic production, for genome mining in Streptomyces spp.

Discovering potential Streptomyces hormone producers by using disruptants of essential biosynthetic genes as indicator strains

(2017) Nguyen B Thao et al.   JOURNAL OF ANTIBIOTICS

AvaR2, a pseudo γ-butyrolactone receptor homologue fromStreptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth

(2016) Jianya Zhu et al.   MOLECULAR MICROBIOLOGY

Isolation and Biosynthesis of an Azoxyalkene Compound Produced by a Multiple Gene Disruptant ofStreptomyces rochei

(2015) Hirofumi Kunitake et al.   CHEMBIOCHEM

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor

(2015) Xiao Li et al.   Scientific Reports

Genetic and biochemical analysis of the antibiotic biosynthetic gene clusters on theStreptomyceslinear plasmid

(2014) Kenji Arakawa   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Blockage of the early step of lankacidin biosynthesis caused a large production of pentamycin, citreodiol and epi-citreodiol in Streptomyces rochei

(2014) Zhisheng Cao et al.   JOURNAL OF ANTIBIOTICS

A γ-butyrolactone-sensing activator/repressor, JadR3, controls a regulatory mini-network for jadomycin biosynthesis

(2014) Zhengzhong Zou et al.   MOLECULAR MICROBIOLOGY

Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain

(2013) Jian-Bo Wang et al.   BIOTECHNOLOGY LETTERS

Towards a new science of secondary metabolism

(2013) Arryn Craney et al.   JOURNAL OF ANTIBIOTICS

Pleiotropic Control of Secondary Metabolism and Morphological Development by KsbC, a Butyrolactone Autoregulator Receptor Homologue in Kitasatospora setae

(2012) Aiyada Aroonsri et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei

(2012) Kenji Arakawa et al.   CHEMBIOCHEM

Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis

(2011) S. Kitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation, structural elucidation, and biosynthesis of 15-norlankamycin derivatives produced by a type-II thioesterase disruptant of Streptomyces rochei

(2011) Kenji Arakawa et al.   TETRAHEDRON

Regulation of Lankamycin Biosynthesis inStreptomyces rocheiby Two SARP Genes,srrYandsrrZ

(2010) Toshihiro SUZUKI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Characterization and Manipulation of the Pathway-Specific Late Regulator AlpW Reveals Streptomyces ambofaciens as a New Producer of Kinamycins

(2010) R. Bunet et al.   JOURNAL OF BACTERIOLOGY

“Pseudo” γ-Butyrolactone Receptors Respond to Antibiotic Signals to Coordinate Antibiotic Biosynthesis

(2010) Gangming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

Extensive Mutational Analysis of Modular-Iterative Mixed Polyketide Biosynthesis of Lankacidin inStreptomyces rochei

(2009) Satoshi TATSUNO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Strategies for the Discovery of New Natural Products by Genome Mining

(2009) Malek Zerikly et al.   CHEMBIOCHEM

Analysis of Two Additional Signaling Molecules in Streptomyces coelicolor and the Development of a Butyrolactone-Specific Reporter System

(2009) Nai-Hua Hsiao et al.   CHEMISTRY & BIOLOGY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator

(2009) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Synthesis of the Angucyclinone Antibiotic Alpomycin in Streptomyces ambofaciens by the Autoregulator Receptor AlpZ and Its Specific Ligand

(2008) R. Bunet et al.   JOURNAL OF BACTERIOLOGY

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining

(2008) C. Corre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2)

(2003) Eriko Takano et al.   MOLECULAR MICROBIOLOGY