Towards a new science of secondary metabolism

A Synthetic, Species-Specific Activator of Secondary Metabolism and Sporulation inStreptomyces coelicolor

(2012) Salman Ahmed et al.   CHEMBIOCHEM

Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism

(2012) Arryn Craney et al.   CHEMISTRY & BIOLOGY

Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor

(2012) Zhenyu Yu et al.   MOLECULAR MICROBIOLOGY

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

A Two-Step Mechanism for the Activation of Actinorhodin Export and Resistance in Streptomyces coelicolor

(2012) Y. Xu et al.   mBio

Exploration and Mining of the Bacterial Terpenome

(2011) David E. Cane et al.   ACCOUNTS OF CHEMICAL RESEARCH

Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis

(2011) Jingfan Qiu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The ECF sigma factor SigT regulates actinorhodin production in response to nitrogen stress in Streptomyces coelicolor

(2011) Wei-Hong Feng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

S-Adenosyl-L-methionine Activates Actinorhodin Biosynthesis by Increasing Autophosphorylation of the Ser/Thr Protein Kinase AfsK inStreptomyces coelicolorA3(2)

(2011) Ying-Yu JIN et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Secondary metabolites of soil Bacillus spp.

(2011) Estibaliz Sansinenea et al.   BIOTECHNOLOGY LETTERS

Discovery of Antibacterials and Other Bioactive Compounds from Microorganisms — Evaluating Methodologies for Discovery and Generation of Non-Ribosomal Peptide Antibiotics

(2011) K. Witting et al.   CURRENT DRUG TARGETS

Identification and Characterization of CdgB, a Diguanylate Cyclase Involved in Developmental Processes in Streptomyces coelicolor

(2011) N. T. Tran et al.   JOURNAL OF BACTERIOLOGY

Complex Transcriptional Control of the Antibiotic Regulator afsS in Streptomyces: PhoP and AfsR Are Overlapping, Competitive Activators

(2011) F. Santos-Beneit et al.   JOURNAL OF BACTERIOLOGY

Marine actinomycetes as an emerging resource for the drug development pipelines

(2011) Sergey B. Zotchev   JOURNAL OF BIOTECHNOLOGY

Enhanced Flavonoid Production in Streptomyces venezuelae via Metabolic Engineering

(2011) Sung Ryeol Park   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Improvement of Transformation Efficiency by Strategic Circumvention of Restriction Barriers in Streptomyces griseus

(2011) Hirokazu Suzuki   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin inStreptomyces roseosporus

(2011) Wei-Ting Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor

(2011) Ana Yepes et al.   PLoS One

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis

(2011) S. Kitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145

(2010) X. Ou et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Strain Improvement of Streptomyces roseosporus for Daptomycin Production by Rational Screening of He–Ne Laser and NTG Induced Mutants and Kinetic Modeling

(2010) Guanghai Yu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Control of secondary metabolism by farX, which is involved in the γ-butyrolactone biosynthesis of Streptomyces lavendulae FRI-5

(2010) Shigeru Kitani et al.   ARCHIVES OF MICROBIOLOGY

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

(2010) Juan-Francisco Martín et al.   CURRENT OPINION IN MICROBIOLOGY

Giant linear plasmids in Streptomyces: a treasure trove of antibiotic biosynthetic clusters

(2010) Haruyasu Kinashi   JOURNAL OF ANTIBIOTICS

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1

(2010) Nancy L McKenzie et al.   JOURNAL OF ANTIBIOTICS

Characterization and Manipulation of the Pathway-Specific Late Regulator AlpW Reveals Streptomyces ambofaciens as a New Producer of Kinamycins

(2010) R. Bunet et al.   JOURNAL OF BACTERIOLOGY

Regulation of a Novel Gene Cluster Involved in Secondary Metabolite Production in Streptomyces coelicolor

(2010) Hindra et al.   JOURNAL OF BACTERIOLOGY

Streptomyces coelicolor A3(2) Produces a New Yellow Pigment Associated with the Polyketide Synthase Cpk

(2010) Krzysztof Pawlik et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

The G243D mutation (afsB mutation) in the principal sigma factor  HrdB alters intracellular ppGpp level and antibiotic production in Streptomyces coelicolor A3(2)

(2010) G. Wang et al.   MICROBIOLOGY-SGM

Regulation of morphological differentiation inS. coelicolorby RNase III (AbsB) cleavage of mRNA encoding the AdpA transcription factor

(2010) Weijing Xu et al.   MOLECULAR MICROBIOLOGY

Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth

(2010) Chris D. Den Hengst et al.   MOLECULAR MICROBIOLOGY

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2)

(2010) Davide D'Alia et al.   Microbial Biotechnology

Characterization of rrdA, a TetR Family Protein Gene Involved in the Regulation of Secondary Metabolism in Streptomyces coelicolor

(2009) X. Ou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

cmdABCDEF, a cluster of genes encoding membrane proteins for differentiation and antibiotic production in Streptomyces coelicolor A3(2)

(2009) Pengfei Xie et al.   BMC MICROBIOLOGY

Biosynthesis of Actinorhodin and Related Antibiotics: Discovery of Alternative Routes for Quinone Formation Encoded in the act Gene Cluster

(2009) Susumu Okamoto et al.   CHEMISTRY & BIOLOGY

Biosynthesis of Bacterial Aromatic Polyketides

(2009) Jixun Zhan   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Phosphopantetheinyl transferase inhibition and secondary metabolism

(2009) Timothy L. Foley et al.   FEBS Journal

Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control sidephore and antibiotic biosynthesis in Streptomyces coelicolor A3(2)

(2009) Sedef Tunca et al.   FEBS Journal

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Self-resistance mechanism in Streptomyces peucetius: Overexpression of drrA, drrB and drrC for doxorubicin enhancement

(2009) Sailesh Malla et al.   MICROBIOLOGICAL RESEARCH

Myxobacteria—‘microbial factories’ for the production of bioactive secondary metabolites

(2009) Silke C. Wenzel et al.   Molecular BioSystems

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesis

(2009) Jia Guo et al.   MOLECULAR GENETICS AND GENOMICS

The role of absC, a novel regulatory gene for secondary metabolism, in zinc-dependent antibiotic production in Streptomyces coelicolor A3(2)

(2009) Andy Hesketh et al.   MOLECULAR MICROBIOLOGY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Genomics of secondary metabolite production by Pseudomonas spp.

(2009) Harald Gross et al.   NATURAL PRODUCT REPORTS

Structural insights into nonribosomal peptide enzymatic assembly lines

(2009) Alexander Koglin et al.   NATURAL PRODUCT REPORTS

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Translating metabolic exchange with imaging mass spectrometry

(2009) Yu-Liang Yang et al.   Nature Chemical Biology

Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

(2009) Gitanjali Yadav et al.   PLoS Computational Biology

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis and Uptake of the Compatible Solutes Ectoine and 5-Hydroxyectoine by Streptomyces coelicolor A3(2) in Response to Salt and Heat Stresses

(2008) J. Bursy et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

NdgR, an IclR-like regulator involved in amino-acid-dependent growth, quorum sensing, and antibiotic production in Streptomyces coelicolor

(2008) Yung-Hun Yang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor

(2008) Dan Shu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Elucidation of the Streptomyces coelicolor Pathway to 2-Undecylpyrrole, a Key Intermediate in Undecylprodiginine and Streptorubin B Biosynthesis

(2008) SangJoon Mo et al.   CHEMISTRY & BIOLOGY

Renaissance in antibacterial discovery from actinomycetes

(2008) R BALTZ   CURRENT OPINION IN PHARMACOLOGY

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

hmgA, transcriptionally activated by HpdA, influences the biosynthesis of actinorhodin in Streptomyces coelicolor

(2008) Yue Zhang et al.   FEMS MICROBIOLOGY LETTERS

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone inStreptomyces coelicolorA3(2)

(2008) Bin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The use of the rare UUA codon to define “Expression Space” for genes involved in secondary metabolism, development and environmental adaptation in Streptomyces

(2008) Keith F. Chater et al.   JOURNAL OF MICROBIOLOGY

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

Mining microbial genomes for new natural products and biosynthetic pathways

(2008) G. L. Challis   MICROBIOLOGY-SGM

Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor

(2008) Sean O'Rourke et al.   MOLECULAR MICROBIOLOGY

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining

(2008) C. Corre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol

(2008) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA