Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities

The therapeutic effects of Rho-ROCK inhibitors on CNS disorders

(2016) Takekazu Kubo   Therapeutics and Clinical Risk Management

Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4

(2015) Dan Jin et al.   BIOCHEMICAL JOURNAL

RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug

(2015) M. Wermke et al.   BLOOD

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours

(2015) O Coutelle et al.   BRITISH JOURNAL OF CANCER

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

(2015) Ping-Pui Wong et al.   CANCER CELL

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

(2015) Karen A. Newell-Litwa et al.   JOURNAL OF CELL BIOLOGY

Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors

(2015) Jeremy Green et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study

(2015) Josep Tabernero et al.   LANCET ONCOLOGY

Angiotensin II increases secreted frizzled-related protein 5 (sFRP5) expression through AT1 receptor/Rho/ROCK1/JNK signaling in cardiomyocytes

(2015) Xin Jin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo

(2015) Y. Xia et al.   MOLECULAR CANCER THERAPEUTICS

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK

(2015) Celia J. Vogel et al.   Pigment Cell & Melanoma Research

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells

(2014) Hideyuki Abe et al.   BMC CANCER

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption

(2014) Chan Kim et al.   CANCER CELL

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention

(2014) Michael P Lisanti et al.   CELL CYCLE

Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK

(2014) Philip W. Voorneveld et al.   GASTROENTEROLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Low Intensity Pulsed Ultrasound (LIPUS) Influences the Multilineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway

(2014) Joji Kusuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axitinib sensitization of high Single Dose Radiotherapy

(2014) Shyam S. Rao et al.   RADIOTHERAPY AND ONCOLOGY

The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues

(2014) Anna-Karin E. Johnsson et al.   Cell Reports

Rethinking the war on cancer

(2013) Douglas Hanahan   LANCET

RhoA is down-regulated at cell–cell contacts via p190RhoGAP-B in response to tensional homeostasis

(2013) Suzanne M. Ponik et al.   MOLECULAR BIOLOGY OF THE CELL

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

(2013) R A Patel et al.   ONCOGENE

Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts

(2013) S M Goicoechea et al.   ONCOGENE

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Selective ROCK2 inhibition in focal cerebral ischemia

(2013) Jeong Hyun Lee et al.   Annals of Clinical and Translational Neurology

Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells

(2012) Tsuyoshi Ohta et al.   CANCER BIOLOGY & THERAPY

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

(2012) Nicola Rath et al.   EMBO REPORTS

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

(2012) Nicolas Reymond et al.   JOURNAL OF CELL BIOLOGY

Enhancement of radiation response with bevacizumab

(2012) Tien Hoang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

(2012) Rongshi Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Increased Vascular Delivery and Efficacy of Chemotherapy after Inhibition of Platelet-Derived Growth Factor-B

(2011) Beverly L. Falcon et al.   AMERICAN JOURNAL OF PATHOLOGY

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

(2011) P. Timpson et al.   CANCER RESEARCH

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage

(2011) Guang Jian Liu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

DNA strand breaks and hypoxia response inhibition mediate the radiosensitisation effect of nitric oxide donors on prostate cancer under varying oxygen conditions

(2010) Grant D. Stewart et al.   BIOCHEMICAL PHARMACOLOGY

Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma

(2010) K Ueno et al.   BRITISH JOURNAL OF CANCER

Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro

(2010) Xueying Yang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo

(2010) Lin Deng et al.   CANCER BIOLOGY & THERAPY

HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways

(2010) Hiromichi Nakabayashi et al.   CANCER SCIENCE

Vessel abnormalization: another hallmark of cancer?Molecular mechanisms and therapeutic implications

(2010) Katrien De Bock et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis

(2010) Brad A. Bryan et al.   FASEB JOURNAL

Fasudil Inhibits Lysophosphatidic Acid-Induced Invasiveness of Human Ovarian Cancer Cells

(2010) Seiji Ogata et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Change in Pattern of Relapse After Antiangiogenic Therapy in High-Grade Glioma

(2010) Ashwatha Narayana et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

Phase II Study of Bevacizumab Plus Temozolomide During and After Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Multiforme

(2010) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549

(2010) Fang Zhu et al.   MEDICAL ONCOLOGY

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone

(2009) S. Liu et al.   CANCER RESEARCH

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

(2009) C. Hahmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

(2008) B. Joshi et al.   CANCER RESEARCH

Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer

(2008) Akiko Horiuchi et al.   CANCER SCIENCE

Blockade of RhoRho-associated coiled coil-forming kinase signaling can prevent progression of hepatocellular carcinoma in matrix metalloproteinase-dependent manner

(2008) Feng Xue et al.   HEPATOLOGY RESEARCH

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

(2008) K. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Provascular strategy: Targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment

(2008) Pierre Sonveaux   RADIOTHERAPY AND ONCOLOGY