Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β′ Subunit

On the intrinsic constraint of bacterial growth rate: M. tuberculosis’s view of the protein translation capacity

(2018) Manlu Zhu et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found inMycobacterium tuberculosis

(2017) Vadim Molodtsov et al.   MOLECULAR MICROBIOLOGY

Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures

(2017) Elizabeth A. Hubin et al.   Nature Communications

Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA

(2017) Elizabeth A Hubin et al.   eLife

NusA-dependent transcription termination prevents misregulation of global gene expression

(2016) Smarajit Mondal et al.   Nature Microbiology

Mutations in RNA Polymerase Bridge Helix and Switch Regions Affect Active-Site Networks and Transcript-Assisted Hydrolysis

(2015) Nan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

A NusG paralogue from Mycobacterium tuberculosis, Rv0639, has evolved to interact with ribosomal protein S10 (Rv0700) but not to function as a transcription elongation–termination factor

(2015) B. Sudha Kalyani et al.   MICROBIOLOGY-SGM

Mutations in the CRE pocket of bacterial RNA polymerase affect multiple steps of transcription

(2015) Ivan Petushkov et al.   NUCLEIC ACIDS RESEARCH

Fitness costs of rifampicin resistance inMycobacterium tuberculosisare amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase

(2014) Taeksun Song et al.   MOLECULAR MICROBIOLOGY

Reversibility of antibiotic resistance

(2014) Martin Sundqvist   UPSALA JOURNAL OF MEDICAL SCIENCES

Mycobacterial RNA Polymerase Requires a U-Tract at Intrinsic Terminators and Is Aided by NusG at Suboptimal Terminators

(2014) A. Czyz et al.   mBio

Molecular Characterization of Multidrug-Resistant Mycobacterium tuberculosis Isolated in Nepal

(2012) Ajay Poudel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Fidelity of Transcription

(2012) Jeffrey Strathern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and Characterization of RNA PolymeraserpoBMutations That Alter Transcription Slippage during Elongation inEscherichia coli

(2012) Yan Ning Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dual switch controls bacterial enhancer-dependent transcription

(2012) Simone C. Wiesler et al.   NUCLEIC ACIDS RESEARCH

Characterization of rifampin-resistant isolates of Mycobacterium tuberculosis from Sichuan in China

(2012) Ke Tang et al.   TUBERCULOSIS

Genotypic detection of rifampicin-resistant M. tuberculosis strains in Syrian and Lebanese patients

(2012) Abdulkader Rahmo et al.   Journal of Infection and Public Health

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro

(2011) Sumandeep K. Gill et al.   TUBERCULOSIS

Multiple roles of the RNA polymerase β′ SW2 region in transcription initiation, promoter escape, and RNA elongation

(2010) Danil Pupov et al.   NUCLEIC ACIDS RESEARCH

Fitness cost of drug resistance inMycobacterium tuberculosis

(2009) S. Gagneux   CLINICAL MICROBIOLOGY AND INFECTION

Allosteric control of Escherichia coli rRNA promoter complexes by DksA

(2009) S. T. Rutherford et al.   GENES & DEVELOPMENT

Transcription Elongation Complex Stability

(2009) Xiaoqing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the 12-Subunit RNA Polymerase II Refined with the Aid of Anomalous Diffraction Data

(2009) Peter A. Meyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Reversal of RNA Polymerase II Active Site Closing Controls Fidelity of Transcription Elongation

(2008) Maria L. Kireeva et al.   MOLECULAR CELL

Genome-wide analysis of the intrinsic terminators of transcription across the genus Mycobacterium

(2008) A. Mitra et al.   TUBERCULOSIS