Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found inMycobacterium tuberculosis

Resistance to rifampicin: a review

(2014) Beth P Goldstein   JOURNAL OF ANTIBIOTICS

Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity against Rifampicin-resistantMycobacterium tuberculosis

(2014) Aeshna Nigam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fitness costs of rifampicin resistance inMycobacterium tuberculosisare amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase

(2014) Taeksun Song et al.   MOLECULAR MICROBIOLOGY

Optimization of recombinant Mycobacterium tuberculosis RNA polymerase expression and purification

(2014) Rajdeep Banerjee et al.   TUBERCULOSIS

Mycobacterial RNA Polymerase Requires a U-Tract at Intrinsic Terminators and Is Aided by NusG at Suboptimal Terminators

(2014) A. Czyz et al.   mBio

GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides

(2014) Yu Zhang et al.   eLife

Transcription inhibition by the depsipeptide antibiotic salinamide A

(2014) David Degen et al.   eLife

X-ray Crystal Structure ofEscherichia coliRNA Polymerase σ70Holoenzyme

(2013) Katsuhiko S. Murakami   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins

(2013) Vadim Molodtsov et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of their Complex

(2013) Yuhong Zuo et al.   MOLECULAR CELL

Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of  70 domain 1.1

(2013) B. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and Characterization of RNA PolymeraserpoBMutations That Alter Transcription Slippage during Elongation inEscherichia coli

(2012) Yan Ning Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro

(2011) Sumandeep K. Gill et al.   TUBERCULOSIS

Joint X-ray and neutron refinement withphenix.refine

(2010) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Rifamycins – Obstacles and opportunities

(2010) Paul A. Aristoff et al.   TUBERCULOSIS

Review of knowledge for rational design and identification of anti-tubercular compounds

(2009) Mohammad Imran Siddiqi et al.   Expert Opinion on Drug Discovery

Tuberculosis Drug Resistance Mutation Database

(2009) Andreas Sandgren et al.   PLOS MEDICINE