Targeting TRPV1 for pain relief: limits, losers and laurels

Hyperactive when young, hypoactive and overweight when aged: Connecting the dots in the story about locomotor activity, body mass, and aging in Trpv1 knockout mice

(2016) Samuel P. Wanner et al.   Aging-US

TRPV1 antagonists may exacerbate sepsis in aged mice: Should we be nervous?

(2012) Zenaide M. Quezado et al.   CELL CYCLE

Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory

(2012) Samuel P. Wanner et al.   CELL CYCLE

TRP channels as therapeutic targets in airway disorders: a patent review

(2012) Delia Preti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

(2011) A. L. Krarup et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population

(2011) Oriel Carreño et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Disruption of the Transient Receptor Potential Vanilloid 1 Can Affect Survival, Bacterial Clearance, and Cytokine Gene Expression during Murine Sepsis

(2011) Virginia Guptill et al.   ANESTHESIOLOGY

Therapeutic Targeting of TRP Channels - The TR(i)P to Pain Relief

(2011) Samer R. Eid   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Vanilloid Agonist Resiniferatoxin for Interventional-Based Pain Control

(2011) Michael J. Iadarola et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Therapeutic Targeting of TRPV1 by Resiniferatoxin, from Preclinical Studies to Clinical Trials

(2011) Igor Kissin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic pain

(2011) Lynn R. Webster et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of duration of postherpetic neuralgia on efficacy analyses in a multicenter, randomized, controlled study of NGX-4010, an 8% capsaicin patch evaluated for the treatment of postherpetic neuralgia

(2010) Lynn R Webster et al.   BMC Neurology

Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath

(2010) Valéria Tékus et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Randomized, Controlled, Open-Label Study of the Long-Term Effects of NGX-4010, a High-Concentration Capsaicin Patch, on Epidermal Nerve Fiber Density and Sensory Function in Healthy Volunteers

(2010) William R. Kennedy et al.   JOURNAL OF PAIN

Long-Term Safety of NGX-4010, a High-Concentration Capsaicin Patch, in Patients with Peripheral Neuropathic Pain

(2010) David M. Simpson et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist

(2010) Brian D. Bates et al.   PAIN

A Multicenter, Randomized, Double-Blind, Controlled Study of NGX-4010, a High-Concentration Capsaicin Patch, for the Treatment of Postherpetic Neuralgia

(2010) Gordon A. Irving et al.   PAIN MEDICINE

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Vanilloid-Induced Conduction Analgesia: Selective, Dose-Dependent, Long-Lasting, with a Low Level of Potential Neurotoxicity

(2009) Igor Kissin   ANESTHESIA AND ANALGESIA

Capsaicin (TRPV1 Agonist) Therapy for Pain Relief

(2009) Helena Knotkova et al.   CLINICAL JOURNAL OF PAIN

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

(2009) A. A. Romanovsky et al.   PHARMACOLOGICAL REVIEWS

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

(2009) Khadija Alawi et al.   PHARMACOLOGY & THERAPEUTICS

Selective Targeting of TRPV1 Expressing Sensory Nerve Terminals in the Spinal Cord for Long Lasting Analgesia

(2009) Joseph A. Jeffry et al.   PLoS One

Peripheral TRPV1 Receptors As Targets for Drug Development: New Molecules and Mechanisms

(2008) Arpad Szallasi et al.   CURRENT PHARMACEUTICAL DESIGN

Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists

(2008) Laxmikant A Gharat et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

TRPV1-null mice are protected from diet-induced obesity

(2008) Arianne L. Motter et al.   FEBS LETTERS

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

(2008) S. G. Lehto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study

(2008) Miroslav Backonja et al.   LANCET NEUROLOGY

Mutation I136V Alters Electrophysiological Properties of the NaV1.7 Channel in a Family with Onset of Erythromelalgia in the Second Decade

(2008) Xiaoyang Cheng et al.   Molecular Pain

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy

(2008) D. M. Simpson et al.   NEUROLOGY

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN