Single-Cell Mass Spectrometry Approaches to Explore Cellular Heterogeneity

Categorizing Cells on the Basis of their Chemical Profiles: Progress in Single-Cell Mass Spectrometry

(2017) Troy J. Comi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Degradation Rate in Arabidopsis thaliana Leaf Growth and Development

(2017) Lei Li et al.   PLANT CELL

Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry

(2017) Hongying Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Single-cell analysis by ambient mass spectrometry

(2017) Yunyun Yang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Review of combined isotopic and optical nanoscopy

(2017) Katharina N. Richter et al.   Neurophotonics

Measuring synaptic vesicles using cellular electrochemistry and nanoscale molecular imaging

(2017) Nhu T. N. Phan et al.   Nature Reviews Chemistry

Single Cell Peptide Heterogeneity of Rat Islets of Langerhans

(2016) Erik T. Jansson et al.   ACS Chemical Biology

Nano Secondary Ion Mass Spectrometry Imaging of Dopamine Distribution Across Nanometer Vesicles

(2016) Jelena Lovrić et al.   ACS Nano

Single-cell mass spectrometry with multi-solvent extraction identifies metabolic differences between left and right blastomeres in the 8-cell frog (Xenopus) embryo

(2016) Rosemary M. Onjiko et al.   ANALYST

Raman spectroscopy: an evolving technique for live cell studies

(2016) Rachael Smith et al.   ANALYST

Protocol of single cells preparation for time of flight secondary ion mass spectrometry

(2016) Justyna Bobrowska et al.   ANALYTICAL BIOCHEMISTRY

Fast Single-Cell Patterning for Study of Drug-Induced Phenotypic Alterations of HeLa Cells Using Time-of-Flight Secondary Ion Mass Spectrometry

(2016) Lu Huang et al.   ANALYTICAL CHEMISTRY

High-Resolution Live-Cell Imaging and Analysis by Laser Desorption/Ionization Droplet Delivery Mass Spectrometry

(2016) Jae Kyoo Lee et al.   ANALYTICAL CHEMISTRY

A New Method and Mass Spectrometer Design for TOF-SIMS Parallel Imaging MS/MS

(2016) Gregory L. Fisher et al.   ANALYTICAL CHEMISTRY

Single Cell Proteomics Using Frog (Xenopus laevis) Blastomeres Isolated from Early Stage Embryos, Which Form a Geometric Progression in Protein Content

(2016) Liangliang Sun et al.   ANALYTICAL CHEMISTRY

Multicolor Fluorescence Detection-Based Microfluidic Device for Single-Cell Metabolomics: Simultaneous Quantitation of Multiple Small Molecules in Primary Liver Cells

(2016) Qingling Li et al.   ANALYTICAL CHEMISTRY

Molecular Imaging of Biological Samples on Nanophotonic Laser Desorption Ionization Platforms

(2016) Sylwia A. Stopka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single-Cell Mass Spectrometry for Discovery Proteomics: Quantifying Translational Cell Heterogeneity in the 16-Cell Frog (Xenopus ) Embryo

(2016) Camille Lombard-Banek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Three-dimensional localization of polymer nanoparticles in cells using ToF-SIMS

(2016) Daniel J. Graham et al.   Biointerphases

Mass Cytometry: Single Cells, Many Features

(2016) Matthew H. Spitzer et al.   CELL

NanoSIMS chemical imaging combined with correlative microscopy for biological sample analysis

(2016) Haibo Jiang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Silver nanoparticles for the detection of cell surface antigens in mass cytometry

(2016) Axel Ronald Schulz et al.   CYTOMETRY PART A

Enhanced multiplexing in mass cytometry using osmium and ruthenium tetroxide species

(2016) Raúl Catena et al.   CYTOMETRY PART A

Single-cell mass spectrometry reveals the importance of genetic diversity and plasticity for phenotypic variation in nitrogen-limited Chlamydomonas

(2016) Jasmin Krismer et al.   ISME Journal

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

(2016) Jacek R. Wiśniewski et al.   Journal of Proteomics

Analysis of Chemotherapeutic Drug Delivery at the Single Cell Level Using 3D-MSI-TOF-SIMS

(2016) Quentin P. Vanbellingen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Label-free Quantification of Proteins in Single Embryonic Cells with Neural Fate in the Cleavage-Stage Frog (Xenopus laevis) Embryo using Capillary Electrophoresis Electrospray Ionization High-Resolution Mass Spectrometry (CE-ESI-HRMS)

(2016) Camille Lombard-Banek et al.   MOLECULAR & CELLULAR PROTEOMICS

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage

(2016) Junyoung O Park et al.   Nature Chemical Biology

Highly multiplexed simultaneous detection of RNAs and proteins in single cells

(2016) Andreas P Frei et al.   NATURE METHODS

Atmospheric pressure MALDI mass spectrometry imaging of tissues and cells at 1.4-μm lateral resolution

(2016) Mario Kompauer et al.   NATURE METHODS

Cell-specific localization of alkaloids inCatharanthus roseusstem tissue measured with Imaging MS and Single-cell MS

(2016) Kotaro Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging mass spectrometry: Molecular microscopy for the new age of biology and medicine

(2016) Richard M. Caprioli   PROTEOMICS

Three-dimensional localization of polymer nanoparticles in cells using ToF-SIMS

(2016) Daniel J. Graham et al.   Biointerphases

A neuron-in-capillary platform for facile collection and mass spectrometric characterization of a secreted neuropeptide

(2016) Chang Young Lee et al.   Scientific Reports

High resolution ion mobility-mass spectrometry for separation and identification of isomeric lipids

(2015) M. Groessl et al.   ANALYST

Classification of Large Cellular Populations and Discovery of Rare Cells Using Single Cell Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

(2015) Ta-Hsuan Ong et al.   ANALYTICAL CHEMISTRY

Study of Phospholipids in Single Cells Using an Integrated Microfluidic Device Combined with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

(2015) Weiyi Xie et al.   ANALYTICAL CHEMISTRY

Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging

(2015) Melissa K. Passarelli et al.   ANALYTICAL CHEMISTRY

Energy Charge, Redox State, and Metabolite Turnover in Single Human Hepatocytes Revealed by Capillary Microsampling Mass Spectrometry

(2015) Linwen Zhang et al.   ANALYTICAL CHEMISTRY

Microfluidic Sample Preparation for Single Cell Analysis

(2015) Sanjin Hosic et al.   ANALYTICAL CHEMISTRY

Secondary-Ion Mass Spectrometry of Genetically Encoded Targets

(2015) Ingrid C. Vreja et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes

(2015) Xianchan Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Screening of Chlamydomonas reinhardtii Populations with Single-Cell Resolution by Using a High-Throughput Microscale Sample Preparation for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

(2015) Jasmin Krismer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Direct metabolomics for plant cells by live single-cell mass spectrometry

(2015) Takashi Fujii et al.   Nature Protocols

Live Single-Cell Plant Hormone Analysis by Video-Mass Spectrometry

(2015) Takafumi Shimizu et al.   PLANT AND CELL PHYSIOLOGY

Single-cell mass spectrometry reveals small molecules that affect cell fates in the 16-cell embryo

(2015) Rosemary M. Onjiko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy

(2015) G. K. Behbehani et al.   Cancer Discovery

Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

(2015) Antonis Koussounadis et al.   Scientific Reports

Characterization of the E. coli proteome and its modifications during growth and ethanol stress

(2015) Boumediene Soufi et al.   Frontiers in Microbiology

In Situ metabolic analysis of single plant cells by capillary microsampling and electrospray ionization mass spectrometry with ion mobility separation

(2014) Linwen Zhang et al.   ANALYST

The Single-Probe: A Miniaturized Multifunctional Device for Single Cell Mass Spectrometry Analysis

(2014) Ning Pan et al.   ANALYTICAL CHEMISTRY

High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis

(2014) Haibo Jiang et al.   JOURNAL OF LIPID RESEARCH

Spatiotemporal lipid profiling during early embryo development ofXenopus laevisusing dynamic ToF-SIMS imaging

(2014) Hua Tian et al.   JOURNAL OF LIPID RESEARCH

Matrix-free single-cell LDI-MS investigations of the diatomsCoscinodiscus graniiandThalassiosira pseudonana

(2014) Tino Jaschinski et al.   JOURNAL OF MASS SPECTROMETRY

Systematic identification of cell size regulators in budding yeast

(2014) I. Soifer et al.   Molecular Systems Biology

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption

(2014) Benjamin L Wang et al.   NATURE BIOTECHNOLOGY

Bayesian approach to single-cell differential expression analysis

(2014) Peter V Kharchenko et al.   NATURE METHODS

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

(2014) Charlotte Giesen et al.   NATURE METHODS

Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development

(2014) Liangliang Sun et al.   Scientific Reports

Metabolic Differences in Microbial Cell Populations Revealed by Nanophotonic Ionization

(2013) Bennett N. Walker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted Multiplex Imaging Mass Spectrometry in Transmission Geometry for Subcellular Spatial Resolution

(2013) Gwendoline Thiery-Lavenant et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Accounting for technical noise in single-cell RNA-seq experiments

(2013) Philip Brennecke et al.   NATURE METHODS

Characterization of Metabolic States of Arabidopsis thaliana Under Diverse Carbon and Nitrogen Nutrient Conditions via Targeted Metabolomic Analysis

(2013) Shigeru Sato et al.   PLANT AND CELL PHYSIOLOGY

Mass spectrometry-based metabolomics of single yeast cells

(2013) A. J. Ibanez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Metabolomics: Analytical and Biological Perspectives

(2013) R. Zenobi   SCIENCE

Small is fast: astrocytic glucose and lactate metabolism at cellular resolution

(2013) L. F. Barros et al.   Frontiers in Cellular Neuroscience

Single-Cell Metabolomics: Changes in the Metabolome of Freshly Isolated and Cultured Neurons

(2012) Peter Nemes et al.   ACS Chemical Neuroscience

Nanophotonic Ionization for Ultratrace and Single-Cell Analysis by Mass Spectrometry

(2012) Bennett N. Walker et al.   ANALYTICAL CHEMISTRY

Single Cell Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

(2012) Yvonne Schober et al.   ANALYTICAL CHEMISTRY

Observation of Subcellular Metabolite Gradients in Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry

(2012) Jessica A. Stolee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals

(2012) H. Tani et al.   GENOME RESEARCH

Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS

(2012) Andre Zavalin et al.   JOURNAL OF MASS SPECTROMETRY

Mass spectrometry imaging and profiling of single cells

(2012) Eric J. Lanni et al.   Journal of Proteomics

Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism

(2012) Matthew L. Steinhauser et al.   NATURE

Automated whole-cell patch-clamp electrophysiology of neurons in vivo

(2012) Suhasa B Kodandaramaiah et al.   NATURE METHODS

Laser–nanostructure interactions for ion production

(2012) Jessica A. Stolee et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Metabolic Differentiation of Neuronal Phenotypes by Single-cell Capillary Electrophoresis–Electrospray Ionization-Mass Spectrometry

(2011) Peter Nemes et al.   ANALYTICAL CHEMISTRY

Single-cell metabolomics comes of age: new developments in mass spectrometry profiling and imaging

(2011) Aleš Svatoš   ANALYTICAL CHEMISTRY

In Situ Cell-by-Cell Imaging and Analysis of Small Cell Populations by Mass Spectrometry

(2011) Bindesh Shrestha et al.   ANALYTICAL CHEMISTRY

Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact

(2011) Kristin J Boggio et al.   Expert Review of Proteomics

Systems-wide Proteomic Analysis in Mammalian Cells Reveals Conserved, Functional Protein Turnover

(2011) Sidney B. Cambridge et al.   JOURNAL OF PROTEOME RESEARCH

Normalization using ploidy and genomic DNA copy number allows absolute quantification of transcripts, proteins and metabolites in cells

(2011) Hiroshi Shimada et al.   Plant Methods

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Assessment of laser-induced thermal load on silicon nanostructures based on ion desorption yields

(2010) Bennett N. Walker et al.   APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Tailored Silicon Nanopost Arrays for Resonant Nanophotonic Ion Production

(2010) Bennett N. Walker et al.   Journal of Physical Chemistry C

High-density micro-arrays for mass spectrometry

(2010) Pawel L. Urban et al.   LAB ON A CHIP

Measuring the turnover rates of Arabidopsis proteins using deuterium oxide: an auxin signaling case study

(2010) Xiao-Yuan Yang et al.   PLANT JOURNAL

Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation

(2010) M. E. Kurczy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry

(2009) Bindesh Shrestha et al.   ANALYTICAL CHEMISTRY

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

Live Single-cell Mass Spectrometry

(2009) Tsutomu MASUJIMA   ANALYTICAL SCIENCES

Use of reverse-phase liquid chromatography, linked to tandem mass spectrometry, to profile the Calvin cycle and other metabolic intermediates in Arabidopsis rosettes at different carbon dioxide concentrations

(2009) Stéphanie Arrivault et al.   PLANT JOURNAL

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification

(2008) Hajime Mizuno et al.   JOURNAL OF MASS SPECTROMETRY