Journal
BIOINTERPHASES
Volume 11, Issue 2, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1116/1.4934795
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Funding
- Cancer Research Institute
- NIH [EB-002027]
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Time-of-flight secondary ion mass spectrometry (ToF-SIMS) three-dimensional (3D) depth profiling and a novel background subtraction method were used to localize polymeric nanoparticles within cells. Results showed that ToF-SIMS 3D depth profiling is capable of localizing polymer nanoparticles within HeLa cells. ToF-SIMS results compared well with optical images of cells incubated with fluorescently labeled polymer nanoparticles, with both imaging techniques demonstrating clustering of nanoparticles in punctate regions consistent with endosomal localization as anticipated based on the nanoparticle design. (C) 2015 American Vacuum Society.
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