Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction

Speeding up enzyme discovery and engineering with ultrahigh-throughput methods

(2018) Hans Adrian Bunzel et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase

(2017) Cathleen Zeymer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Conformational Dynamics in the Evolution of Retro-Aldolase Activity

(2017) Adrian Romero-Rivera et al.   ACS Catalysis

Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases

(2016) Xavier Garrabou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip

(2016) Karin M. Krone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme

(2016) Xavier Garrabou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting

(2016) Richard Obexer et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products

(2016) Nina G. Schmidt et al.   ACS Catalysis

A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates

(2015) Xavier Garrabou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Optical Methods for Enantiomeric Excess Analysis: From Enantioselective Indicator Displacement Assays to Exciton-Coupled Circular Dichroism

(2014) Hyun Hwa Jo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Engineering aldolases as biocatalysts

(2014) Claire L Windle et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase

(2014) N. Preiswerk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Enzyme Design

(2013) Gert Kiss et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of Protein Catalysts

(2013) Donald Hilvert   Annual Review of Biochemistry

De novo enzymes by computational design

(2013) Hajo Kries et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering stereoselectivity of ThDP-dependent enzymes

(2013) Helen C. Hailes et al.   FEBS Journal

Precision is essential for efficient catalysis in an evolved Kemp eliminase

(2013) Rebecca Blomberg et al.   NATURE

Evolution of a designed retro-aldolase leads to complete active site remodeling

(2013) Lars Giger et al.   Nature Chemical Biology

Robust design and optimization of retroaldol enzymes

(2012) Eric A. Althoff et al.   PROTEIN SCIENCE

Current Trends in Asymmetric Synthesis with Aldolases

(2011) Pere Clapés et al.   ADVANCED SYNTHESIS & CATALYSIS

Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

(2010) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structurally Informed Site-Directed Mutagenesis of a Stereochemically Promiscuous Aldolase To Afford Stereochemically Complementary Biocatalysts

(2010) Sylvain F. Royer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY