Current Trends in Asymmetric Synthesis with Aldolases

Redesign of the Phosphate Binding Site of L-Rhamnulose- 1-Phosphate Aldolase towards a Dihydroxyacetone Dependent Aldolase

(2011) Xavier Garrabou et al.   ADVANCED SYNTHESIS & CATALYSIS

Systematic Screening for Catalytic Promiscuity in 4-Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity

(2011) Ellen Zandvoort et al.   CHEMBIOCHEM

Structure-guided redesign of d-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation

(2011) Mariana Gutierrez et al.   CHEMICAL COMMUNICATIONS

Broadening Deoxysugar Glycodiversity: Natural and Engineered Transaldolases Unlock a Complementary Substrate Space

(2011) Madhura Rale et al.   CHEMISTRY-A EUROPEAN JOURNAL

Efficient immobilization of fructose-6-phosphate aldolase in layered double hydroxide: improved stereoselective synthesis of sugar analogues

(2011) Christine Guérard-Hélaine et al.   NEW JOURNAL OF CHEMISTRY

A Mutant D-Fructose-6-Phosphate Aldolase (Ala129Ser) with Improved Affinity towards Dihydroxyacetone for the Synthesis of Polyhydroxylated Compounds

(2010) José A. Castillo et al.   ADVANCED SYNTHESIS & CATALYSIS

Preparation of optically active β-hydroxy-α-amino acid by immobilized Escherichia coli cells with serine hydroxymethyl transferase activity

(2010) Gen-Hai Zhao et al.   AMINO ACIDS

Threonine aldolases—screening, properties and applications in the synthesis of non-proteinogenic β-hydroxy-α-amino acids

(2010) Nina Dückers et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Comparison of Two Metal-Dependent Pyruvate Aldolases Related by Convergent Evolution: Substrate Specificity, Kinetic Mechanism, and Substrate Channeling

(2010) Weijun Wang et al.   BIOCHEMISTRY

Microbial production of N-acetylneuraminic acid by genetically engineered Escherichia coli

(2010) Mari Ishikawa et al.   CARBOHYDRATE RESEARCH

Protease-catalyzed direct aldol reaction

(2010) Hai-Hong Li et al.   CATALYSIS COMMUNICATIONS

Redesigning the Active Site of Transaldolase TalB from Escherichia coli: New Variants with Improved Affinity towards Nonphosphorylated Substrates

(2010) Sarah Schneider et al.   CHEMBIOCHEM

Expanding the Application Range of Aldolases: Novel Asymmetric Syntheses of α-Methylated β-Hydroxy α-Amino Acids and β-Amino Alcohols

(2010) Katrin Baer et al.   ChemCatChem

Structure-Guided Minimalist Redesign of the L-Fuculose-1-Phosphate Aldolase Active Site: Expedient Synthesis of Novel Polyhydroxylated Pyrrolizidines and their Inhibitory Properties Against Glycosidases and Intestinal Disaccharidases

(2010) Xavier Garrabou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Preparation and Characterization of a Bifunctional Aldolase/Kinase Enzyme: A More Efficient Biocatalyst for CC Bond Formation

(2010) Laura Iturrate et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biocatalysts by evolution

(2010) Christian Jäckel et al.   CURRENT OPINION IN BIOTECHNOLOGY

Recent progress in stereoselective synthesis with aldolases

(2010) Pere Clapés et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Nuclease p1: a new biocatalyst for direct asymmetric aldol reaction under solvent-free conditions

(2010) Hai-Hong Li et al.   GREEN CHEMISTRY

Ultrafast X-ray scattering: structural dynamics from diatomic to protein molecules

(2010) Hyotcherl Ihee et al.   INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY

Structural and Kinetic Characterization of 4-Hydroxy-4-methyl-2-oxoglutarate/4-Carboxy-4-hydroxy-2-oxoadipate Aldolase, a Protocatechuate Degradation Enzyme Evolutionarily Convergent with the HpaI and DmpG Pyruvate Aldolases

(2010) Weijun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Class I Tagatose-1,6-bisphosphate Aldolase

(2010) Clotilde LowKam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution

(2010) Ivan Campeotto et al.   JOURNAL OF MOLECULAR BIOLOGY

Structurally Informed Site-Directed Mutagenesis of a Stereochemically Promiscuous Aldolase To Afford Stereochemically Complementary Biocatalysts

(2010) Sylvain F. Royer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic synthesis of differentially protected 3-deoxysugars

(2010) Dennis G. Gillingham et al.   Nature Chemistry

Origins of catalysis by computationally designed retroaldolase enzymes

(2010) J. K. Lassila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the reduced Schiff-base intermediate complex of transaldolase B from escherichia coli: Mechanistic implications for class I aldolases

(2010) Jia Jia et al.   PROTEIN SCIENCE

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

New chemo-enzymatic route toward N-acetylneuraminic acid derivatives with alkyl groups at C-7 hydroxyl group

(2010) Jordi Calveras et al.   TETRAHEDRON

Advances in the Biology and Chemistry of Sialic Acids

(2009) Xi Chen et al.   ACS Chemical Biology

Activated α,β-Unsaturated Aldehydes as Substrate of Dihydroxyacetone Phosphate (DHAP)-Dependent Aldolases in the Context of a Multienzyme System

(2009) Israel Sánchez-Moreno et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalytic Access to α,α-Dialkyl-α-amino Acids by a Mechanism-Based Approach

(2009) Kateryna Fesko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Self- and Cross-Aldol Reactions of Glycolaldehyde Catalyzed by D-Fructose-6-phosphate Aldolase

(2009) Xavier Garrabou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coupled bioconversion for preparation of N-acetyl-d-neuraminic acid using immobilized N-acetyl-d-glucosamine-2-epimerase and N-acetyl-d-neuraminic acid lyase

(2009) Shiyuan Hu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An efficient method for N-acetyl-d-neuraminic acid production using coupled bacterial cells with a safe temperature-induced system

(2009) Yinan Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Charge Stabilization and Entropy Reduction of Central Lysine Residues in Fructose-Bisphosphate Aldolase

(2009) Miguel St-Jean et al.   BIOCHEMISTRY

Characterization of an Aldolase−Dehydrogenase Complex That Exhibits Substrate Channeling in the Polychlorinated Biphenyls Degradation Pathway

(2009) Perrin Baker et al.   BIOCHEMISTRY

Diastereoselective synthesis of l-threo-3,4-dihydroxyphenylserine by low-specific l-threonine aldolase mutants

(2009) Hui-Jeong Gwon et al.   BIOTECHNOLOGY LETTERS

Improvement of an Acid Phosphatase/DHAP-Dependent Aldolase Cascade Reaction by Using Directed Evolution

(2009) Teunie van Herk et al.   CHEMBIOCHEM

Suppressed Native Hydrolytic Activity of a Lipase to Reveal Promiscuous Michael Addition Activity in Water

(2009) Maria Svedendahl et al.   ChemCatChem

Substrate channelling in an engineered bifunctional aldolase/kinase enzyme confers catalytic advantage for C–C bond formation

(2009) Laura Iturrate et al.   CHEMICAL COMMUNICATIONS

Dihydroxyacetone Phosphate Aldolase Catalyzed Synthesis of Structurally Diverse Polyhydroxylated Pyrrolidine Derivatives and Evaluation of their Glycosidase Inhibitory Properties

(2009) Jordi Calveras et al.   CHEMISTRY-A EUROPEAN JOURNAL

Protein Flexibility and Metal Coordination Changes in DHAP-Dependent Aldolases

(2009) Aurora Jiménez et al.   CHEMISTRY-A EUROPEAN JOURNAL

D-Fructose-6-phosphate Aldolase in Organic Synthesis: Cascade Chemical-Enzymatic Preparation of Sugar-Related Polyhydroxylated Compounds

(2009) Alda Lisa Concia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanism of Substrate Recognition and Insight into Feedback Inhibition of Homocitrate Synthase fromThermus thermophilus

(2009) Takuya Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Observation of an Enamine Intermediate in Amine Catalysis

(2009) Xueyong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Challenges in the computational design of proteins

(2009) M. Suarez et al.   Journal of the Royal Society Interface

Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids

(2009) Hongzhi Cao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Crystallography without crystals. I. The common-line method for assembling a three-dimensional diffraction volume from single-particle scattering

(2008) V. L. Shneerson et al.   ACTA CRYSTALLOGRAPHICA SECTION A

Directed Evolution of Methanococcus jannaschii Citramalate Synthase for Biosynthesis of 1-Propanol and 1-Butanol by Escherichia coli

(2008) S. Atsumi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Directed evolution of aldolases for exploitation in synthetic organic chemistry

(2008) Amanda Bolt et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Replacement of a Phenylalanine by a Tyrosine in the Active Site Confers Fructose-6-phosphate Aldolase Activity to the Transaldolase ofEscherichia coliand Human Origin

(2008) Sarah Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dynamic view of enzyme catalysis

(2008) Aurora Jiménez et al.   JOURNAL OF MOLECULAR MODELING

The Putative Diels−Alderase Macrophomate Synthase is an Efficient Aldolase

(2008) Jörg M. Serafimov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE

Antenna Domain Mobility and Enzymatic Reaction ofl-Rhamnulose-1-phosphate Aldolase†,‡

(2007) Dirk Grueninger et al.   BIOCHEMISTRY

Characterization and crystal structure of Escherichia coli KDPGal aldolase

(2007) Matthew J. Walters et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Four types of threonine aldolases: Similarities and differences in kinetics/thermodynamics

(2007) Kateryna Fesko et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC