Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer

HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells

(2015) Dae-Hee Lee et al.   CELLULAR SIGNALLING

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

(2015) Guangchao Li et al.   Oncotarget

STAT3 in Epithelial Cells Regulates Inflammation and Tumor Progression to Malignant State in Colon

(2015) Andrew V. Nguyen et al.   NEOPLASIA

An IL6-STAT3 loop mediates resistance to PI3K inhibitors by inducing epithelial–mesenchymal transition and cancer stem cell expansion in human breast cancer cells

(2014) Lin Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blockage of Stat3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition

(2014) Hyeon-Ok Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors

(2014) Kodappully Sivaraman Siveen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

(2014) Khalid Abubaker et al.   BMC CANCER

Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours

(2014) X Zhang et al.   BRITISH JOURNAL OF CANCER

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

(2014) Johanna C. Bendell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer

(2014) Roheena Z. Panni et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways

(2014) Mingli Liu et al.   CELLULAR SIGNALLING

AAG8 promotes carcinogenesis by activating STAT3

(2014) Bing Sun et al.   CELLULAR SIGNALLING

The Role of STAT3 Signaling in Mediating Tumor Resistance to Cancer Therapy

(2014) Fiona Tan et al.   CURRENT DRUG TARGETS

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

A microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFκB and STAT3 in Colorectal Cancer Cells

(2014) Sanhong Liu et al.   GASTROENTEROLOGY

Targeting JAK1/STAT3 Signaling Suppresses Tumor Progression and Metastasis in a Peritoneal Model of Human Ovarian Cancer

(2014) W. Wen et al.   MOLECULAR CANCER THERAPEUTICS

AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers

(2014) Ahmed Katsha et al.   Molecular Oncology

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Enzalutamide in Metastatic Prostate Cancer before Chemotherapy

(2014) Tomasz M. Beer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential roles of STAT3 in the initiation and growth of lung cancer

(2014) J Zhou et al.   ONCOGENE

VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2

(2014) D Zhao et al.   ONCOGENE

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

Stat3 promotes IL-10 expression in lupus T cells throughtrans-activation and chromatin remodeling

(2014) Christian M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF- B to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes

(2014) M. Xiang et al.   Science Signaling

Cytokine-Induced Slowing of STAT3 Nuclear Import; Faster Basal Trafficking of the STAT3β Isoform

(2014) Ivan H. W. Ng et al.   TRAFFIC

The IL-6–STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression

(2014) Q Zhu et al.   Cell Death & Disease

SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma

(2014) Jung-Chen Su et al.   NEOPLASIA

EGFR-mediated tumor immunoescape

(2014) Fernando Concha-Benavente et al.   OncoImmunology

STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

(2014) Jennifer Kim et al.   Cancers

The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer

(2014) Jennifer Bishop et al.   Cancers

Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling

(2013) Hui-Hui Cao et al.   BIOCHEMICAL PHARMACOLOGY

Emerging role of tumor-associated macrophages as therapeutic targets in patients with metastatic renal cell carcinoma

(2013) Matteo Santoni et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer

(2013) Y.H. Xu et al.   EJSO

Investigational Janus kinase inhibitors

(2013) Constantine S Tam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Aurora Kinase A Promotes Inflammation and Tumorigenesis in Mice and Human Gastric Neoplasia

(2013) Ahmed Katsha et al.   GASTROENTEROLOGY

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

(2013) L Guo et al.   ONCOGENE

Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer

(2013) N R West et al.   ONCOGENE

AZD1480: A Phase I Study of a Novel JAK2 Inhibitor in Solid Tumors

(2013) E. R. Plimack et al.   ONCOLOGIST

Interplay between microRNAs and the STAT3 signaling pathway in human cancers

(2013) Qing Cao et al.   PHYSIOLOGICAL GENOMICS

Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells

(2013) Seyung S. Chung et al.   PLoS One

Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells

(2013) Chengfei Liu et al.   PROSTATE

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases

(2013) F Hayakawa et al.   Blood Cancer Journal

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

(2012) Ivan H. W. Ng et al.   BIOCHEMICAL JOURNAL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

(2012) Massimo Nabissi et al.   CARCINOGENESIS

Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFα- and NK cytotoxicity

(2012) Dorota W. Kulesza et al.   EXPERIMENTAL CELL RESEARCH

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation

(2012) Maria Beatrice Morelli et al.   INTERNATIONAL JOURNAL OF CANCER

First-Line Erlotinib Followed by Second-Line Cisplatin-Gemcitabine Chemotherapy in Advanced Non–Small-Cell Lung Cancer: The TORCH Randomized Trial

(2012) Cesare Gridelli et al.   JOURNAL OF CLINICAL ONCOLOGY

A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line

(2012) Inès Souissi et al.   Molecular Cancer

Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non-Small Cell Lung Cancer with T790M Resistance Mutation

(2012) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Correlation of Activated STAT3 Expression with Clinicopathologic Features in Lung Adenocarcinoma and Squamous Cell Carcinoma

(2012) Richeng Jiang et al.   Molecular Diagnosis & Therapy

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

(2012) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis

(2012) Claire Harrison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

(2012) Howard I. Scher et al.   NEW ENGLAND JOURNAL OF MEDICINE

STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma

(2012) Brendan D. Looyenga et al.   PLoS One

Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells

(2011) Huan-Chih Chiu et al.   BIOCHEMICAL PHARMACOLOGY

Antitumorigenic potential of STAT3 alternative splicing modulation

(2011) F. Zammarchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th1 and Th17 cells

(2010) Jesse M. Damsker et al.   Annals of the New York Academy of Sciences

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner

(2010) Massimo Nabissi et al.   CARCINOGENESIS

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model

(2010) Saima Hassan et al.   INTERNATIONAL JOURNAL OF CANCER

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

(2009) Yongzhan Nie et al.   NATURE CELL BIOLOGY

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cytokine Signaling Modules in Inflammatory Responses

(2008) John J. O'Shea et al.   IMMUNITY

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

(2008) Maciej Kujawski et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of signal transducers and activators of transcription in colon cancer

(2007) Lidija Klampfer   Frontiers in Bioscience-Landmark