Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity

LC–MS-based metabolomics: an update

(2014) Zhong-Ze Fang et al.   ARCHIVES OF TOXICOLOGY

Pluripotent stem cell-derived hepatocyte-like cells

(2014) R.E. Schwartz et al.   BIOTECHNOLOGY ADVANCES

Filling the Pipeline - New Drugs for an Old Disease

(2014) Matthias Stehr et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

In Vitro Human Hepatocyte-Based Experimental Systems for the Evaluation of Human Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity in Drug Development

(2014) Albert Li   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Alcoholic and non-alcoholic steatohepatitis

(2014) Manuela G. Neuman et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

How can we discover safer drugs?

(2014) Jorrit J Hornberg et al.   Future Medicinal Chemistry

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

(2014) Mitchell R. McGill et al.   HEPATOLOGY

Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice

(2014) Shohei Takai et al.   JOURNAL OF APPLIED TOXICOLOGY

Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors

(2014) Raphaëlle Luisier et al.   TOXICOLOGICAL SCIENCES

UCP2, a mitochondrial protein regulated at multiple levels

(2013) Massimo Donadelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Generation and utility of genetically humanized mouse models

(2013) Nico Scheer et al.   DRUG DISCOVERY TODAY

Review: Toxicometabolomics

(2013) Mounir Bouhifd et al.   JOURNAL OF APPLIED TOXICOLOGY

Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice

(2013) Jie Cheng et al.   JOURNAL OF LIPID RESEARCH

Stable Isotope- and Mass Spectrometry-based Metabolomics as Tools in Drug Metabolism: A Study Expanding Tempol Pharmacology

(2013) Fei Li et al.   JOURNAL OF PROTEOME RESEARCH

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy

(2013) Feng Li et al.   NATURE MEDICINE

Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications

(2013) Nico Scheer et al.   XENOBIOTICA

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

(2013) Shigeyuki Kitamura et al.   XENOBIOTICA

Systems biology tools for toxicology

(2012) Suzanne Geenen et al.   ARCHIVES OF TOXICOLOGY

Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis

(2012) Tsutomu Matsubara et al.   Cell Metabolism

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity

(2012) Andrew D. Patterson et al.   HEPATOLOGY

Identification ofN-Acetyltaurine as a Novel Metabolite of Ethanol through Metabolomics-guided Biochemical Analysis

(2012) Xiaolei Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FXR signaling in the enterohepatic system

(2012) Tsutomu Matsubara et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

(2012) Masakazu Kakuni et al.   TOXICOLOGY LETTERS

Application ofin vivometabolomics to preclinical/toxicological studies: case study on phenytoin-induced systemic toxicity

(2012) H Kamp et al.   Bioanalysis

Xenobiotic Metabolomics: Major Impact on the Metabolome

(2011) Caroline H. Johnson et al.   Annual Review of Pharmacology and Toxicology

Metabolomic Screening and Identification of the Bioactivation Pathways of Ritonavir

(2011) Feng Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Profiling the Reactive Metabolites of Xenobiotics Using Metabolomic Technologies

(2011) Feng Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Humanized Transgenic Mouse Models for Drug Metabolism and Pharmacokinetic Research

(2011) Hong-Wu Shen et al.   CURRENT DRUG METABOLISM

Knockout and transgenic mice in glutathione transferase research

(2011) Colin J. Henderson et al.   DRUG METABOLISM REVIEWS

UPLC–MS-based Urine Metabolomics Reveals Indole-3-lactic Acid and Phenyllactic Acid as Conserved Biomarkers for Alcohol-induced Liver Disease in thePpara-null Mouse Model

(2011) Soumen K. Manna et al.   JOURNAL OF PROTEOME RESEARCH

Differentiation and Transplantation of Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells

(2011) Samira Asgari et al.   Stem Cell Reviews and Reports

Transgenic Animal Models in Toxicology: Historical Perspectives and Future Outlook

(2011) Darrell R. Boverhof et al.   TOXICOLOGICAL SCIENCES

Pregnane X receptor- andCYP3A4-humanized mouse models and their applications

(2010) Jie Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Noninvasive Biomarkers for Alcohol-Induced Liver Disease Using Urinary Metabolomics and thePpara-null Mouse

(2010) Soumen K. Manna et al.   JOURNAL OF PROTEOME RESEARCH

Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching

(2010) André LeBlanc et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets

(2009) Hanneke MJ Nijland et al.   AIDS

HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic review

(2009) Wouter FW Bierman et al.   AIDS

Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-Oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity

(2009) Chi Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Pharmacogenomics of Membrane Transporters Project: Research at the Interface of Genomics and Transporter Pharmacology

(2009) D L Kroetz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

3-Ketocholanoic Acid Is the Major in Vitro Human Hepatic Microsomal Metabolite of Lithocholic Acid

(2009) A. K. Deo et al.   DRUG METABOLISM AND DISPOSITION

Hepatotoxicity and Gastrointestinal Intolerance When Healthy Volunteers Taking Rifampin Add Twice-Daily Atazanavir and Ritonavir

(2009) David W Haas et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

(2009) T. A. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell based approaches for evaluation of drug-induced liver injury

(2009) Mhairi L. Greer et al.   TOXICOLOGY

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity

(2009) Richard D. Beger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolomics for early detection of drug-induced kidney injury: review of the current status

(2009) Kurt J Boudonck et al.   Bioanalysis

NMR-Based Metabolic Profiling and Metabonomic Approaches to Problems in Molecular Toxicology

(2008) Muireann Coen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo

(2008) T. Matsubara et al.   DRUG METABOLISM AND DISPOSITION

Bile acids: Trying to understand their chemistry and biology with the hope of helping patients

(2008) Alan F. Hofmann   HEPATOLOGY

Disruption of theUgt1Locus in Mice Resembles Human Crigler-Najjar Type I Disease

(2008) Nghia Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

(2008) Nico Scheer et al.   JOURNAL OF CLINICAL INVESTIGATION

Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment

(2008) C. Cheung et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS