Systems biology tools for toxicology

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics-pharmacodynamics platform

(2011) M. Swat et al.   Interface Focus

Systems biochemistry in practice: experimenting with modelling and understanding, with regulation and control

(2010) Hans V. Westerhoff et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Why does yeast ferment? A flux balance analysis study

(2010) Evangelos Simeonidis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs

(2010) B Rodriguez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast

(2009) Karen van Eunen et al.   FEBS Journal

Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations

(2009) Hanna M. Härdin et al.   FEBS Journal

Quantification of statin effects on hepatic cholesterol synthesis by transient 13C-flux analysis

(2009) Klaus Maier et al.   METABOLIC ENGINEERING

Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters

(2009) Gilles Curien et al.   Molecular Systems Biology

Sloppiness, robustness, and evolvability in systems biology

(2008) Bryan C Daniels et al.   CURRENT OPINION IN BIOTECHNOLOGY

Integrating systems approaches into pharmaceutical sciences

(2008) Hans V. Westerhoff et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Systems biology towards life in silico: mathematics of the control of living cells

(2008) Hans V. Westerhoff et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Identification of metabolic fluxes in hepatic cells from transient13C-labeling experiments: Part I. Experimental observations

(2007) Ute Hofmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of metabolic fluxes in hepatic cells from transient13C-labeling experiments: Part II. Flux estimation

(2007) Klaus Maier et al.   BIOTECHNOLOGY AND BIOENGINEERING