Review
Pharmacology & Pharmacy
Meng Li, Qiong Luo, Yanyan Tao, Xin Sun, Chenghai Liu
Summary: This article reviews the accumulated literature on drug-induced liver injury (DILI) with evidence-based medicine researches and discusses the limitations of clinical studies and the prospective development for DILI therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Fantian Zeng, Sureya Nijiati, Yangtengyu Liu, Qinqin Yang, Xiaomin Liu, Qianyu Zhang, Shi Chen, Anqi Su, Hehe Xiong, Changrong Shi, Congbo Cai, Zhongning Lin, Xiaoyuan Chen, Zijian Zhou
Summary: An artemisinin-based probe (Art-Gd) was developed for contrast-enhanced magnetic resonance imaging of ferroptosis (feMRI) in anticancer drug-induced acute cardiac/kidney injuries (ACI/AKI). The probe showed great feasibility in early diagnosis of ACI/AKI, providing imaging evidence for the different mechanisms of action of ferroptosis-targeted agents. This study presents a feMRI strategy with simple chemistry and robust efficacy for early evaluation of anticancer drug-induced ACI/AKI.
Article
Pharmacology & Pharmacy
Sheng Zhang, Chao Li, Tingting Feng, Shuai Cao, Heng Zhou, Limin Li, Qing Hu, Xiuhong Mao, Shen Ji
Summary: The study investigated metabolic changes in serum and kidney tissues of mice exposed to Realgar, revealing associations with amino acid metabolism, lipid metabolism, glutathione metabolism, and purine metabolism pathways in Realgar nephrotoxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Efstathia Liatsou, Ioanna Tatouli, Andreas Mpozikas, Maria-Markella Pavlou, Hariklia Gakiopoulou, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Sofoklis Kontogiannis, Meletios Athanasios Dimopoulos
Summary: Tenofovir disoproxil fumarate (TDF) is a drug used to treat patients with HIV and HBV infections, but it may cause acute renal failure and Fanconi syndrome in a few cases. The risk of renal toxicity in HBV patients appears to be low, but kidney function should still be monitored.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Hui Nee Geo, Dharmani Devi Murugan, Zamri Chik, Anwar Norazit, Yiing Yee Foo, Bey Fen Leo, Yin Yin Teo, Sharifah Zamiah Syed Binti Syed Abdul Kadir, Yinghan Chan, Hann Juang Chai, Maria Medel, Nor Azizan Abdullah, Edward J. Johns, Maria J. Vicent, Lip Yong Chung, Lik Voon Kiew
Summary: This article reviews the current status and future trajectories of renal nanomedicine research for the management of acute kidney injury (AKI). The use of nanosized drug carriers (NDCs) for the delivery of reno-protective agents is evaluated, with a focus on improving renal tissue targeting selectivity and efficacy. The need to identify accumulation sites of NDCs in renal tissues during in vivo assessments is highlighted.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Yong Jin Lim, Steven G. Xiu, M. Sara Kuruvilla, Eric Winquist, Stephen Welch, Morgan Black, Lauren N. Faught, Jasmine Lee, Michael J. Rieder, Tom D. Blydt-Hansen, Michael Zappitelli, Bradley L. Urquhart
Summary: Metabolomics analysis identified potential biomarkers, including glycine, hippuric acid sulfate, 3-hydroxydecanedioc acid, and suberate, for predicting cisplatin-induced acute kidney injury.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Yong Jin Lim, Nicholas C. Tonial, Emily D. Hartjes, Aaron Haig, Thomas J. Velenosi, Bradley L. Urquhart
Summary: In this study, metabolomics analysis was used to identify early diagnostic biomarkers for cisplatin-induced nephrotoxicity. The results showed that several metabolites related to mitochondrial function and gut microbiome were altered in the early stages following cisplatin treatment. These findings suggest that cisplatin has detrimental effects on mitochondrial function and may involve the gut microbiome in the development of acute kidney injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Biwen Hu, Ling Ye, Tong Li, Zeying Feng, Longjian Huang, Chengjun Guo, Li He, Wei Tan, Guoping Yang, Zhiling Li, Chengxian Guo
Summary: In this study, the occurrence of drug-induced acute kidney injury (DIKI) in Chinese pediatric patients was investigated using a pediatric intensive care database. The results showed that furosemide injection, midazolam injection, 20% albumin prepared from human plasma injection, fentanyl citrate injection, compound glycyrrhizin injection, vancomycin hydrochloride for intravenous, and milrinone lactate injection were associated with DIKI in critically ill pediatric patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Jing Yang, Xiaoyan Miao, Yu Guan, Chaojin Chen, Sufang Chen, Xinmin Zhang, Xue Xiao, Zheng Zhang, Zhengyuan Xia, Tinghui Yin, Ziqing Hei, Weifeng Yao
Summary: Utilizing platelet membrane-coated microbubbles for molecular ultrasound imaging has potential to improve early detection of sepsis-induced acute kidney injury, showing promising results in a rat model. This approach may enhance selective adhesion to damaged endothelium and offer a diagnostic advantage over traditional methods.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Romejko, Magdalena Markowska, Stanislaw Niemczyk
Summary: Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein secreted by immune cells in response to inflammation. It serves as a biomarker for acute kidney injury and is also elevated in chronic kidney disease and cardiovascular diseases. NGAL is involved in the progression of renal function decrease and is associated with complications and mortality due to kidney failure. It is also useful in the diagnostic processes of cardiovascular diseases and plays a role in inflammatory states, hypertension, obesity, diabetes, and carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yan Zhang, Yang Li, Nana Gao, Yinglan Gong, Wanyu Shi, Xiaodan Wang
Summary: This study investigated the effect of PFOA exposure during pregnancy on the kidneys of offspring mice. The results showed that PFOA influenced gene expression, metabolite levels, and oxidative stress in the kidneys of offspring mice. This suggests that PFOA may have negative effects on kidney function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yuncui Yu, Xiaolu Nie, Yiming Zhao, Wang Cao, Yuefeng Xie, Xiaoxia Peng, Xiaoling Wang
Summary: This study proposes a quantitative algorithm to detect drug-induced kidney injury (DIKI) signals in children using an electronic health record (EHR) database. The study analyzed 12 years of medical data and used a two-stage procedure to detect DIKI signals. Six drugs were found to be associated with DIKI and identified as potential signals in pediatrics. The findings highlight the potential of EHRs to complement traditional spontaneous reporting systems for drug safety signal detection in a pediatric setting.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pediatrics
Rupesh Raina, Arwa Nada, Raghav Shah, Hany Aly, Saurav Kadatane, Carolyn Abitbol, Mihika Aggarwal, Jay Koyner, Javier Neyra, Sidharth Kumar Sethi
Summary: Acute kidney injury has a significant impact on pediatric and neonatal patients, and artificial intelligence provides advanced predictive models for early detection and prediction, improving diagnosis and treatment.
PEDIATRIC NEPHROLOGY
(2023)
Review
Pharmacology & Pharmacy
Caterina Valentino, Barbara Vigani, Giuseppina Sandri, Franca Ferrari, Silvia Rossi
Summary: Neurological disorders affecting both CNS and PNS remain critical and challenging pathologies. Drug delivery systems based on polysaccharides have gained attention for their physical-chemical properties. This review provides an overview of polysaccharides used for developing therapeutic strategies for repairing and regenerating the damaged nervous system, with a focus on spinal cord and peripheral nerve injury treatments.
Review
Immunology
Yan-zhong Han, Zhi-tao Ma, Ming-xi Zhou, Ming Niu, Xu Zhao, Yu-ming Guo, Xin-hua Song, Ya-wen Lu, Zhao-fang Bai, Zhen Li, Han Gao, Yong-kang Zhao, Jia-bo Wang, Xiao-he Xiao, Jing Jing
Summary: By using metabolomics analysis, it has been found that drug-induced liver injury with autoantibodies may not be a homogeneous group in terms of pathogenesis, including a subset with autoimmune hepatitis tendencies. This finding calls for further investigation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)