Article
Multidisciplinary Sciences
Loren M. DeVito, Edward A. Dennis, Barbara B. Kahn, Gerald Shulman, Joseph L. Witztum, Sudeshna Sadhu, Joseph Nickels, Matthew Spite, Susan Smyth, Sarah Spiegel
Summary: Recent research has revealed the cellular and molecular functions of bioactive lipids as signaling molecules in regulating inflammation and lipid metabolism, which can help identify mechanisms targeted to prevent or treat cardiometabolic conditions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Ke Zhu, Yu Yao, Kun Wang, Fuqiang Shao, Ziyang Zhu, Yangmeihui Song, Zhangyongxue Zhou, Dawei Jiang, Xiaoli Lan, Chunxia Qin
Summary: This study reveals that berberine (BBR) treats myocardial infarction (MI) by regulating inflammatory responses, as determined by network pharmacology. Platelet membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used to deliver BBR, which are more enriched in the infarcted myocardium and less uptaken in the liver compared to PLGA nanoparticles. BBR@PLGA@PLT NPs significantly increase the number of repaired macrophages and decrease the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium on day three after MI. On the 28th day after MI, the BBR@PLGA@PLT group shows a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and excellent angiogenesis effect.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Martijn J. W. Evers, Wenjuan Du, Qiangbing Yang, Sander A. A. Kooijmans, Aryan Vink, Mies van Steenbergen, Pieter Vader, Saskia C. A. de Jager, Sabine A. Fuchs, Enrico Mastrobattista, Joost P. G. Sluijter, Zhiyong Lei, Raymond Schiffelers
Summary: This study evaluated the functional ability of lipid nanoparticles (LNPs) to deliver mRNA to the ischemic myocardium. The results showed that LNPs accumulated in the infarct area of the heart and delivered functional modRNA to cardiac cells. The targeted cells within the infarct area were mainly cardiac fibroblasts.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-xi Yang, Ke Shi, Hua-yan Xu, Yong He, Min Ma, Lu Zhang, Jun-long Wang, Xue-sheng Li, Chuan Fu, Hong Li, Bin Zhou, Xiao-yue Zhou, Zhi Yang, Ying-kun Guo, Zhi-gang Yang
Summary: This study aimed to assess inflammation in the remote myocardium post-myocardial infarction (MI) and its association with left ventricular (LV) remodeling using T2 mapping. The results found significant increases in remote T2 post-MI, indicating potential inflammatory response and pathological changes. Both animal and human experiments demonstrated remote myocardial alterations in T2, with variations in remote T2 independently associated with LV remodeling in patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Medicine, Research & Experimental
Xia Lu, Boshen Yang, Ruiqiang Qi, Qifei Xie, Taixi Li, Jie Yang, Tingting Tong, Kaifan Niu, Mingyu Li, Weijun Pan, Yongxin Zhang, Dongmei Shi, Suiji Li, Cuilian Dai, Chengxing Shen, Xiaoqing Wang, Yan Wang, Juan Song
Summary: WWP1 is upregulated in cardiomyocytes post-MI and under hypoxic conditions, and its overexpression promotes cardiomyocyte apoptosis and exacerbates cardiac dysfunction. Inhibiting WWP1 in cardiomyocytes protects against MI-induced cardiac ischemic injury.
Article
Biochemistry & Molecular Biology
Jishou Zhang, Yao Xu, Cheng Wei, Zheng Yin, Wei Pan, Mengmeng Zhao, Wen Ding, Shuwan Xu, Jianfang Liu, Junping Yu, Jing Ye, Di Ye, Juan-Juan Qin, Jun Wan, Menglong Wang
Summary: This study found that Neo1 deficiency aggravates inflammation and left ventricular remodeling after myocardial infarction by modulating macrophage phenotypes and functions via the JAK1-STAT1 signaling pathway. These findings offer new perspectives for therapeutic targets in myocardial infarction treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Engineering, Biomedical
Lili Bao, Geng Dou, Ran Tian, Yajie Lv, Feng Ding, Siying Liu, Ruifeng Zhao, Lu Zhao, Jun Zhou, Lin Weng, Yan Dong, Bei Li, Shiyu Liu, Xin Chen, Yan Jin
Summary: This study constructs engineered neutrophil apoptotic bodies (eNABs) to simulate natural neutrophil apoptosis, regulating inflammation response and enhancing myocardial infarction (MI) repair.
BIOACTIVE MATERIALS
(2022)
Review
Immunology
Zhiyang Li, Yan Ding, Yudong Peng, Jian Yu, Chengliang Pan, Yifan Cai, Qian Dong, Yucheng Zhong, Ruirui Zhu, Kunwu Yu, Qiutang Zeng
Summary: Macrophages play a crucial role in inflammation, heart protection, and tissue repair after myocardial ischemia and myocardial infarction. IL-38 can regulate macrophage inflammatory response, promote differentiation of M1 macrophages into M2 macrophages, and improve myocardial ischemia and ventricular remodeling.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Yanguo Xin, Xiaodong Zhang, Jingye Li, Hui Gao, Jiayu Li, Junli Li, Wenyu Hu, Hongwei Li
Summary: Ischemic heart disease is a significant global cause of mortality and morbidity, with mitochondrial dysfunction playing a crucial role in its pathogenesis. Targeting mitochondria, including mitophagy, mtROS, and mitochondria-related inflammation, may offer potential therapeutic approaches for this condition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Chun-xia Tian, Ming-yue Li, Xin-xin Shuai, Feng Jiang, Ya-lan Dong, Yang Gui, Zi-li Zhang, Ren-jie Qin, Zhen-yu Kang, Lan Lin, Alexey Sarapultsev, Bin Wu, Shan-shan Luo, De-sheng Hu
Summary: This study found that berberine (BBR) can effectively improve cardiac function after myocardial infarction (MI), and the potential protective mechanism is associated with the regulation of inflammatory responses and the inhibition of macrophage Wnt5a/beta-catenin pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sujin Ju, Leejin Lim, Kwanhwan Wi, Changwon Park, Young-Jae Ki, Dong-Hyun Choi, Heesang Song
Summary: LRP5 may act as a negative regulator of ischemic heart injury through interacting with PHD2 to degrade HIF-1α in hypoxic myocardium, Overexpression of LRP5 promotes cell apoptosis, while silencing LRP5 protects cardiomyocytes from hypoxia. Additionally, specific phosphorylation of LRP5 enhances PHD2 activity, resulting in HIF-1α degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Thomas Bochaton, Simon Leboube, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Nathan Mewton, Camille Amaz, Yvonne Varillon, Eric Bonnefoy-Cudraz, Gilles Rioufol, Tae-Hee Cho, Michel Ovize, Gabriel Bidaux, Norbert Nighoghossian, Laura Mechtouff
Summary: This study compared the profile of circulating inflammatory markers between young and older patients with STEMI or AIS. The results showed that older patients had higher levels of IL-6 and sTNF-RI within the first 48 hours, accompanied by a lower lymphocyte count and a higher neutrophil-lymphocyte ratio.
Article
Biochemistry & Molecular Biology
Wolf-Stephan Rudi, Michael Molitor, Venkata Garlapati, Stefanie Finger, Johannes Wild, Thomas Muenzel, Susanne H. Karbach, Philip Wenzel
Summary: The study shows that early treatment with the ACE inhibitor ramipril after myocardial infarction can reduce cardiac and circulating inflammation, improve retention of hematopoietic precursor cells in the bone marrow, and increase survival rates. Long-term ACE inhibition also limits vascular inflammation and improves endothelial function in mice with ischemic heart failure.
Article
Cardiac & Cardiovascular Systems
Prachi Umbarkar, Suma Ejantkar, Sulivette Y. Ruiz Ramirez, Angelica Toro Cora, Qinkun Zhang, Sultan Tousif, Hind Lal
Summary: Myocardial infarction (MI) is a major cause of death worldwide, and GSK-3 has shown potential as a therapeutic target for cardiovascular diseases. In this study, it was found that GSK-3α in cardiac fibroblasts plays a critical role in the pathological remodeling of ischemic hearts.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Review
Immunology
Irina Kologrivova, Marina Shtatolkina, Tatiana Suslova, Vyacheslav Ryabov
Summary: The burden of heart failure following myocardial infarction remains a major issue in clinical practice. The failure to resolve inflammation post-myocardial injury results in unsuccessful left ventricular remodeling and contributes to heart failure pathogenesis. The immune system's role in heart remodeling is ambiguous, with both protective and damaging effects observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Nataliia Beztsinna, Yoanna Tsvetkova, Jithin Jose, Boutayna Rhourri-Frih, Wa'el Al Rawashdeh, Twan Lammers, Fabian Kiessling, Isabelle Bestel
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Chemistry, Medicinal
Boutayna Rhourri-Frih, Isabelle Renimel, Patrick Chaimbault, Patrice Andre, Gaetan Herbette, Michel Lafosse
Article
Biochemical Research Methods
B. Rhourri-Frih, P. Chaimbault, D. Dequeral, P. Andre, M. Lafosse
JOURNAL OF CHROMATOGRAPHY A
(2012)
Article
Biochemical Research Methods
B. Rhourrhi-Frih, C. West, L. Pasquier, P. Andre, P. Chaimbault, M. Lafosse
JOURNAL OF CHROMATOGRAPHY A
(2012)
Article
Biochemical Research Methods
B. Rhourri-Frih, P. Chaimbault, B. Claude, C. Lamy, P. Andre, M. Lafosse
JOURNAL OF MASS SPECTROMETRY
(2009)
Article
Cardiac & Cardiovascular Systems
Amanda B. Pullen, Jeevan Kumar Jadapalli, Boutayna Rhourri-Frih, Ganesh V. Halade
HEART FAILURE REVIEWS
(2020)
Article
Biochemistry & Molecular Biology
Chaimae Majdi, Carla Pereira, Maria Ines Dias, Ricardo C. Calhelha, Maria Jose Alves, Boutayna Rhourri-Frih, Zoubida Charrouf, Lillian Barros, Joana S. Amaral, Isabel C. F. R. Ferreira
Article
Agricultural Engineering
Fatima-Zahra Alem, Samira Ananthabothla Gita, Lise Cougnaud, Cedric Affnar, Issmail Nounah, Bakri Youssef, Alessandra Lopes de Oliveira, Zoubida Charrouf, Boutayna Rhourri-Frih
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Multidisciplinary Sciences
Gianluca Sighinolfi, Samantha Clark, Landry Blanc, Daniela Cota, Boutayna Rhourri-Frih
Summary: Studies have shown that obesity is closely related to changes in brain structure and function. Through experiments on mice, it was found that a high-fat diet can rapidly alter the brain lipidome, with some changes persisting even after weight loss.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Luigi A. Agrofoglio, Vincent Bezy, Patrick Chaimbault, Raphaeel Delepee, Boutaina Rhourri, Philippe Morin
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2007)