Article
Medicine, Research & Experimental
Vasundhara Kain, Kevin A. Ingle, Namakkal S. Rajasekaran, Ganesh Halade
Summary: The study demonstrates that lack of 12/15LOX can improve post-myocardial infarction survival, enhance the activation of reparative macrophages, modulate miRNA levels, and alleviate renal inflammation in heart failure. These findings provide important clues for further investigation into the role of EETs in macrophage receptor biology.
Review
Cell Biology
Yusra Zaidi, Eslie G. Aguilar, Miguel Troncoso, Daria Ilatovskaya, Kristine Y. DeLeon-Pennell
Summary: Myocardial infarction (MI) results in pathological changes in the left ventricle's extracellular matrix, which can cause cardiac stiffness and affect systolic and diastolic function. The signals released from necrotic tissue initiate an immune cascade and lead to inflammatory response and reparative fibrosis, with immune cells playing key roles in balancing pro-fibrotic and anti-fibrotic responses. This review explores how molecular signals between fibroblasts and immune cells regulate fibrosis post-MI, and discusses emerging pharmacological targets and therapies for inflammation and cardiac fibrosis associated with MI.
CELLULAR SIGNALLING
(2021)
Review
Cardiac & Cardiovascular Systems
Edoardo Bertero, Jan Dudek, Clement Cochain, Murilo Delgobo, Gustavo Ramos, Brenda Gerull, Takahiro Higuchi, Martin Vaeth, Alma Zernecke, Stefan Frantz, Ulrich Hofmann, Christoph Maack
Summary: The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of cardiovascular diseases. This paper provides an overview of the interrelation between inflammation and metabolism, discusses the involvement of disrupted immuno-metabolic interface in cardiovascular disease, and presents new technologies and therapeutic approaches.
CARDIOVASCULAR RESEARCH
(2022)
Review
Immunology
Carlos Zamora, Elisabet Canto, Silvia Vidal
Summary: Patients with chronic inflammatory diseases often have cardiovascular risks due to persistent systemic inflammation and endothelial activation. Activated platelets are considered major players in this inflammation, although their role has become controversial in recent years. Platelets can release both pro- and anti-inflammatory mediators and modulate the function of circulating lymphocytes, monocytes, and neutrophils, but how they exert this dual role is not fully understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Laura Martinez-Arias, Sara Fernandez-Villabrille, Cristina Alonso-Montes, Gonzalo Garcia-Navazo, Maria P. Ruiz-Torres, Ramon Alajarin, Julio Alvarez-Builla, Elena Gutierrez-Calabres, Juan Jose Vaquero-Lopez, Natalia Carrillo-Lopez, Diego Rodriguez-Puyol, Jorge B. Cannata-Andia, Sara Panizo, Manuel Naves-Diaz
Summary: This study examined the effects of GGN1231, a hybrid compound derived from losartan, in a rat model of chronic renal failure. The results showed that GGN1231 reduced cardiovascular damage and fibrosis, suggesting its potential in managing cardiovascular and inflammatory processes.
Article
Hematology
Maggie A. Stanislawski, Leslie A. Lange, Laura M. Raffield, Neil A. Zakai, Mariah Meyer, Kendra Ferrier, Mindy D. Szeto, Colton Leavitt, Jonathan A. Shortt, Timothy A. Thornton, Russell P. Tracy, Paul L. Auer, Alex P. Reiner, Ethan M. Lange, Nels C. Olson
Summary: This study identified a significant association between sCD14 levels and cardiovascular disease outcomes and mortality in a cohort of Black participants from the JHS. Adjusting for cardiovascular disease risk factors and C-reactive protein, higher sCD14 levels were significantly associated with increased risk of mortality, incident coronary heart disease, and incident heart failure. The study also found genetic associations with sCD14, highlighting the importance of genetic factors in these relationships.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Joshua R. Smith, Randal J. Thomas, Amanda R. Bonikowske, Shane M. Hammer, Thomas P. Olson
Summary: This article reviews the sex differences in outpatient phase II cardiac rehabilitation (CR) programming, including CR participation rates, core components, and barriers to participation. Strategies to mitigate these disparities are discussed, along with areas for future research.
CIRCULATION RESEARCH
(2022)
Article
Immunology
Brandon Tejada, Roby Joehanes, Shih-Jen Hwang, Tianxiao Huan, Chen Yao, Jennifer E. Ho, Daniel Levy
Summary: The study found that higher inflammation scores were associated with smoking, older age, higher BMI, systolic blood pressure, lipids, and glucose levels, as well as greater odds of hypertension and diabetes. Additionally, higher baseline scores were linked to increased risk of new-onset cardiovascular disease events and all-cause mortality.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Alberto Navarro-Navajas, Jose David Cruz, Nicolas Ariza-Ordonez, Helman Giral, Jorge Palmezano, Adrian Bolivar-Mejia, Quindo Santana, Ricardo Fernandez, Luisa Durango, Clara Saldarriaga, Juan Camilo Mateus, Diego Garnica, Jose Guillermo Sarta-Garcia, Fernando Lizcano, Carlos Andres Tapias
Summary: Thyroid hormones have significant effects on cardiac function, leading to changes in frequency, contractility, rhythm, and cardiac output, as well as an increased incidence and prevalence of cardiovascular diseases. This article provides an updated review of the impact of hyperthyroidism on various cardiac conditions and emphasizes its importance in perioperative cardiovascular risk evaluation.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Njabulo Ngwenyama, Annet Kirabo, Mark Aronovitz, Francisco Velazquez, Francisco Carrillo-Salinas, Ane M. Salvador, Tania Nevers, Venkataraman Amarnath, Albert Tai, Robert M. Blanton, David G. Harrison, Pilar Alcaide
Summary: The study found that TCR antigen recognition increases in the left ventricle as cardiac dysfunction progresses, with a limited repertoire of activated CD4+ T-cell clonotypes identified in the left ventricle. Antigen presentation of endogenous antigens was necessary for the development of cardiac dysfunction, and scavenging IsoLGs reduced TCR activation and prevented cardiac dysfunction. This highlights the important role of reactive oxygen species-induced formation of IsoLG-modified cardiac neoantigens in TCR-dependent CD4+ T-cell activation within the heart.
Article
Biochemistry & Molecular Biology
David Schumacher, Adelina Curaj, Sakine Simsekyilmaz, Andreas Schober, Elisa A. Liehn, Sebastian F. Mause
Summary: The study found that genetic depletion of miR155 in a dyslipidemic mouse model of myocardial infarction does not reduce infarction size and consecutive heart failure, but it does decrease myofibroblast density in the post-ischemic scar.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Monireh-Sadat Mousavi, Sogol Meknatkhah, Alireza Imani, Parham Geramifar, Gholamhossein Riazi
Summary: This study aims to investigate the unique impacts of chronic physical and psychological stress on the cardiovascular system, revealing that psychological stress has a more significant impact on heart health compared to physical stress, including left ventricular hypertrophy, myocardial ischemia, and neuroinflammation. This highlights the importance of prioritizing psychological well-being during adolescence in preventing the occurrence of cardiovascular diseases in adulthood.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Angela B. Moragrega, Aleksandra Gruevska, Isabel Fuster-Martinez, Ana M. Benedicto, Joan Tosca, Cristina Monton, Victor M. Victor, Juan Esplugues, Ana Blas-Garcia, Nadezda Apostolova
Summary: This study investigated the anti-inflammatory and immunomodulating properties of rilpivirine (RPV). RPV was found to down-regulate inflammatory response, inhibit leukocyte chemotaxis and migration, and suppress the NLRP3 inflammasome pathway. These findings may be of great importance for the identification of novel therapeutic targets or repositioning strategies for chronic liver disease (CLD).
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Daniel Harding, Ming H. A. Chong, Nishant Lahoti, Carola M. Bigogno, Roshni Prema, Saidi A. Mohiddin, Federica Marelli-Berg
Summary: Dilated cardiomyopathy is a heart disease with unknown causes and limited treatment options. Immune dysfunction is believed to play a significant role in its development and progression. Current treatment focuses on symptom management and reducing the risk of sudden cardiac death.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Amanda B. Pullen, Vasundhara Kain, Charles N. Serhan, Ganesh V. Halade
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biochemistry & Molecular Biology
Chaimae Majdi, Carla Pereira, Maria Ines Dias, Ricardo C. Calhelha, Maria Jose Alves, Boutayna Rhourri-Frih, Zoubida Charrouf, Lillian Barros, Joana S. Amaral, Isabel C. F. R. Ferreira
Article
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Lisandra E. de Castro Bras, Kristine Y. DeLeon-Pennell, Nikolaos G. Frangogiannis, Ganesh Halade, Caitlin C. O'Meara, Francis G. Spinale, Zamaneh Kassiri, Jonathan A. Kirk, Petra Kleinbongard, Crystal M. Ripplinger, Keith R. Brunt
Summary: This article summarizes the authors' consensus on how to select the optimal model for conducting experiments in cardiac research, aiming to establish rigor and reproducibility in cardiac physiology research.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
SiddabasaveGowda B. Gowda, Divyavani Gowda, Vasundhara Kain, Hitoshi Chiba, Shu-Ping Hui, Charles E. Chalfant, Vibhu Parcha, Pankaj Arora, Ganesh Halade
Summary: The study explored the relationship between S1P and heart failure, revealing the association between S1P and cardiac repair, as well as the importance of S1P/S1PR1 signaling in cardiac repair in mice. S1P may serve as a therapeutic target for clinical cardiac protection.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Gianluca Sighinolfi, Samantha Clark, Landry Blanc, Daniela Cota, Boutayna Rhourri-Frih
Summary: Studies have shown that obesity is closely related to changes in brain structure and function. Through experiments on mice, it was found that a high-fat diet can rapidly alter the brain lipidome, with some changes persisting even after weight loss.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Ganesh Halade, Vasundhara Kain, Xavier De La Rosa, Merry L. Lindsey
Summary: The type of fat intake can have varying effects on obesity and cardiovascular health, with DHA showing potential for controlling inflammation and improving resolving mechanisms in the heart and kidneys, leading to better survival rates in chronic heart failure patients post-MI.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nicholas W. Carris, Rahul Mhaskar, Emily Coughlin, Easton Bracey, Srinivas M. Tipparaju, Ganesh Halade
Summary: This study identifies IL-2 as an important component of suboptimal inflammation in the pathogenesis of HFpEF.
BMC CARDIOVASCULAR DISORDERS
(2022)
Review
Medicine, General & Internal
Ganesh V. Halade, Dae Hyun Lee
Summary: Unresolved inflammation plays a crucial role in advanced heart failure, initiated by various factors leading to baseline inflammatory diseases. The coordinated recruitment of immune cells, particularly macrophages, after cardiac injury is essential for effective tissue repair and resolution of inflammation. Dysregulation of these processes due to cardiometabolic defects or aging can impair cardiac repair.
Review
Cardiac & Cardiovascular Systems
Lisa C. Heather, Anne D. Hafstad, Ganesh V. Halade, Romain Harmancey, Kimberley M. Mellor, Paras K. Mishra, Erin E. Mulvihill, Miranda Nabben, Michinari Nakamura, Oliver J. Rider, Matthieu Ruiz, Adam R. Wende, John R. Ussher
Summary: Diabetes is a significant risk factor for cardiovascular diseases, and various models have been used to study its mechanisms and impacts. This review aims to provide information on the accuracy of different models in reproducing cardiovascular disease in diabetic individuals, highlighting their advantages, disadvantages, practical challenges, and technical considerations.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ganesh Halade, Vasundhara Kain, Shahriare Hossain, Vibhu Parcha, Nita A. Limdi, Pankaj Arora
Summary: Arachidonate 5-lipoxygenase (ALOX5) is critical in synthesizing specialized pro-resolving mediators that facilitate cardiac repair after cardiac injury. Thus, ALOX5 orchestrates the overlapping phases of inflammation and resolution to facilitate myocardium healing in cardiac repair post-myocardial infarction.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Siddabasave Gowda B. Gowda, Divyavani Gowda, Fengjue Hou, Hitoshi Chiba, Vibhu Parcha, Pankaj Arora, Ganesh V. Halade, Shu-Ping Hui
Summary: This study conducted a comprehensive lipidomic analysis on heart disease patients and healthy individuals, revealing significant differences in lipid profiles between ischemic patients and healthy subjects. Different lipid metabolites were found in the transition from acute to chronic heart failure, with marked increases in PE levels in chronic MI patients, possibly indicating cardiac remodeling.
Article
Biochemistry & Molecular Biology
Ganesh V. Halade, Yusuf Mat, Siddabasave Gowda B. Gowda, Shalini Jain, Shu-Ping Hui, Hariom Yadav, Vasundhara Kain
Summary: Sleep is vital for cardiac health, and sleep deprivation increases the risk of heart attacks. This study explores how sleep fragmentation in an obesity setting affects immune and cardiac health, and found that it disrupts gut homeostasis and reparative mediators, which impairs cardiac repair.
Review
Cardiac & Cardiovascular Systems
Archana Rao, Akul Gupta, Vasundhara Kain, Ganesh V. Halade
Summary: Chronic and uncleared inflammation is the root cause of various cardiovascular diseases. Unhealthy diet, sleep disturbance, sedentary lifestyle, and stress are identified as major extrinsic risk factors. Extrinsic factors directly impact intrinsic factors, regulating immune defense, metabolic health, inflammation-resolution signaling, and cardiac health.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
