Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung

Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD

(2017) Gunnar R. Husebø et al.   EUROPEAN RESPIRATORY JOURNAL

Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation

(2017) Dae Jin Song et al.   JOURNAL OF IMMUNOLOGY

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD

(2017) Tom M A Wilkinson et al.   THORAX

Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ

(2017) Bailing Yan et al.   Scientific Reports

Cigarette Smoke Induces Human Airway Epithelial Senescence via Growth Differentiation Factor 15 Production

(2016) Qun Wu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection

(2016) Anthony Bosco et al.   BMC GENOMICS

MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene

(2016) Qiang Tong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation

(2016) April K. Binder et al.   PLoS One

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

(2016) Xingya Wang et al.   Aging-US

A Tool for Investigating Asthma and COPD Exacerbations: A Newly Manufactured and Well Characterised GMP Wild-Type Human Rhinovirus for Use in the Human Viral Challenge Model

(2016) Daniel J. Fullen et al.   PLoS One

A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD

(2015) Aran Singanayagam et al.   CLINICAL SCIENCE

Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease

(2015) Levent Cem Mutlu et al.   INFLAMMATION

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

(2015) Katrina Blazek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection

(2015) Jason Girkin et al.   JOURNAL OF IMMUNOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Challenges in developing a cross-serotype rhinovirus vaccine

(2015) Nicholas Glanville et al.   Current Opinion in Virology

School Start Times for Middle School and High School Students — United States, 2011–12 School Year

(2015) Anne G. Wheaton et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Hydrodynamic delivery of IL-28B (IFN-λ3) gene ameliorates lung inflammation induced by cigarette smoke exposure in mice

(2014) Chuan Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease—A systematic review

(2014) W.A.R. Zwaans et al.   JOURNAL OF CLINICAL VIROLOGY

Human rhinovirus-induced ISG15 selectively modulates epithelial antiviral immunity

(2014) R S Zaheer et al.   Mucosal Immunology

Occurrence of virus-induced COPD exacerbations during four seasons

(2014) Remco S. Djamin et al.   Infectious Diseases

Experimental rhinovirus infection in COPD: Implications for antiviral therapies

(2013) Natasha Gunawardana et al.   ANTIVIRAL RESEARCH

Human Rhinoviruses

(2013) Samantha E. Jacobs et al.   CLINICAL MICROBIOLOGY REVIEWS

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response

(2013) J. M. Kim et al.   MEDIATORS OF INFLAMMATION

Lower NLRP3 inflammasome activity in NAG-1 transgenic mice is linked to a resistance to obesity and increased insulin sensitivity

(2013) Xingya Wang et al.   Obesity

Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway

(2013) Qun Wu et al.   VIROLOGY

Proteasome inhibitor MG132 induces NAG-1/GDF15 expression through the p38 MAPK pathway in glioblastoma cells

(2012) Sachie Shimizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer

(2012) Xingya Wang et al.   BIOCHEMICAL PHARMACOLOGY

Immunological pathways in virus-induced COPD exacerbations: a role for IL-15

(2012) Mihnea T. Zdrenghea et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

(2012) Laurens A. van Meeteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette smoke induces growth differentiation factor 15 production in human lung epithelial cells: Implication in mucin over-expression

(2011) Qun Wu et al.   Innate Immunity

IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor–associated kinase M

(2011) Qun Wu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Growth Differentiation Factor 15 Is Induced by Hepatitis C Virus Infection and Regulates Hepatocellular Carcinoma-Related Genes

(2011) Youhui Si et al.   PLoS One

Increased Cytokine Response of Rhinovirus-infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease

(2010) Dina Schneider et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages

(2010) D. R. Nagarkar et al.   JOURNAL OF IMMUNOLOGY

β2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells

(2010) Claire A Gross et al.   BMC Pulmonary Medicine

Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells

(2009) M. R. Khaitov et al.   ALLERGY

Nonsteroidal Anti-inflammatory Drug-Activated Gene-1 Expression Inhibits Urethane-Induced Pulmonary Tumorigenesis in Transgenic Mice

(2009) M. Cekanova et al.   Cancer Prevention Research

Serum IP-10 as a Biomarker of Human Rhinovirus Infection at Exacerbation of COPD

(2009) Jennifer K. Quint et al.   CHEST

In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects

(2009) Nilceia Lopez-Souza et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains

(2009) Peter A.B. WARK et al.   RESPIROLOGY

Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells

(2008) Umadevi Sajjan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE