Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Review
Dentistry, Oral Surgery & Medicine
Niamh Kelly, Lewis Winning, Christopher Irwin, Fionnuala T. Lundy, Dermot Linden, Lorcan McGarvey, Gerard J. Linden, Ikhlas A. El Karim
Summary: This systematic review explores the association between poor periodontal health and frequency of COPD exacerbations. Research suggests that periodontal treatment can reduce exacerbation frequency in COPD patients, leading to improved quality of life.
Article
Medicine, General & Internal
Kulothungan Gunasekaran, Swetha Murthi, Kalaimani Elango, Mandeep Singh Rahi, Bright Thilagar, Sathishkumar Ramalingam, Dinesh Voruganti, Vijaya Kumar Paramasivam, Krishna Prasad Kolandaivel, Ashish Arora, Arul Chandran
Summary: Investigating the impact of diabetes on COPD patient outcomes during inpatient hospitalization revealed that patients with COPD and diabetes had longer hospital stays and higher risks of complications, but lower odds of mortality during hospitalization compared to COPD patients without diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Z. Lahmar, E. Ahmed, A. Fort, I. Vachier, A. Bourdin, A. Bergougnoux
Summary: COPD is a chronic airway disease that affects millions of people worldwide and is ranked as the third leading cause of death. Genetic susceptibility, environmental factors, and the combined effects of these factors play important roles in the development of COPD. The Hedgehog signaling pathway and its inhibitor HHIP are potential targets for therapeutic interventions in COPD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Nebal S. Abu Hussein, Stephanie Giezendanner, Pascal Urwyler, Pierre-Olivier Bridevaux, Prashant N. Chhajed, Thomas Geiser, Ladina Joos Zellweger, Malcolm Kohler, David Miedinger, Zahra Pasha, Robert Thurnheer, Christophe von Garnier, Joerg D. Leuppi
Summary: This study describes recurrent exacerbations in a GP-based Swiss COPD cohort and develops a statistical model for predicting exacerbation rates. A nomogram is created to assist clinicians in the decision-making process of COPD care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Joon Young Choi, Yong Bum Park, Tai Joon An, Kwang Ha Yoo, Chin Kook Rhee
Summary: This study evaluated the clinical efficacy of Broncho-Vaxom (BV) in reducing the risk of exacerbations in chronic obstructive pulmonary disease (COPD) patients. The results showed that the use of BV was associated with fewer moderate and moderate-to-severe exacerbations, and also delayed the occurrence of moderate COPD exacerbations.
BMC PULMONARY MEDICINE
(2023)
Article
Respiratory System
Judith Elshof, Judith M. Vonk, Anouschka van der Pouw, Cella van Dijk, Petra Vos, Huib A. M. Kerstjens, Peter J. Wijkstra, Marieke L. Duiverman
Summary: This study evaluated guideline adherence to non-invasive ventilation (NIV) initiation for acute exacerbations of chronic obstructive pulmonary disease (COPD) and its impact on mortality. The overall guideline adherence rate was 82%, and better survival was observed in patients who received NIV when indicated. Therefore, increasing awareness and reducing reluctance in utilizing NIV through healthcare professional training can further enhance NIV treatment in clinical practice and improve patient outcomes.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, General & Internal
Christopher Byron, Christian R. Osadnik
Summary: People with hospitalised acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have low levels of physical activity and high risks of future exacerbations. This study evaluated the amount of physical activity accumulated during hospitalised AECOPDs and the effect on length of stay, physical activity recovery, and readmission risk. The findings suggest that sedentary behavior and light physical activity are the most promising metrics associated with clinically relevant outcomes following AECOPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
Vahideh Ghorani, Mohammad Reza Khazdair, Majid Mirsadraee, Omid Rajabi, Mohammad Hossein Boskabady
Summary: The study suggests that Zataria multiflora may have therapeutic effects on chronic obstructive pulmonary disease (COPD) patients by reducing inflammatory cytokines, improving pulmonary function test values, and alleviating respiratory symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Critical Care Medicine
Min Hyung Ryu, Jeong H. Yun, Jarrett D. Morrow, Aabida Saferali, Peter Castaldi, Robert Chase, Meryl Stav, Zhonghui Xu, Igor Barjaktarevic, MeiLan Han, Wassim Labaki, Yvonne J. Huang, Stephanie Christenson, Wanda O'Neal, Russell Bowler, Don D. Sin, Christine M. Freeman, Jeffrey L. Curtis, Craig P. Hersh
Summary: This study found a correlation between the transcriptome of circulating leukocytes and exacerbations of chronic obstructive pulmonary disease (COPD). Patients with decreased CD4 T cells in their blood were more susceptible to exacerbations. These findings provide new insights into the pathogenesis of COPD and potential strategies for its treatment and management.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yonghong Wu, Zhou Luo, Chuntao Liu
Summary: This study identified differences in fecal microbiome abundance and composition in AECOPD patients compared to stable COPD patients and normal subjects. The variations in fecal microbiota may be associated with the progression of COPD.
Article
Medicine, General & Internal
Michele Vitacca, Laura Comini, Anna Giardini, Adriana Olivares, Giacomo Corica, Mara Paneroni
Summary: The study compared disability changes in COPD patients recovering from acute exacerbation, with and without hospitalization, using the Respiratory ICF Maugeri core set. Regardless of hospitalization need, all patients showed a statistically significant decrease in the rate of higher ICF qualifiers after rehabilitation. The results suggest that pulmonary rehabilitation improves disability in COPD patients, and the use of ICF set as an additional outcome requires further exploration.
ANNALS OF MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Fredrik Nyman
Summary: This article uses an ethnographic approach to study chronic obstructive pulmonary disease (COPD) and finds that patients face complicated cognitive and emotional experiences, requiring holistic solutions that consider psychological processes, contextual factors, and subjective age. The article also highlights the importance of a gerontological perspective in understanding COPD.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Respiratory System
Yan Li, Pingshu Zhang, Zhijie An, Chenyan Yue, Yamin Wang, Yunqiu Liu, Xiaodong Yuan, Ying Ma, Keli Li, Zundong Yin, Liye Wang, Huaqing Wang
Summary: This study aimed to evaluate the effectiveness of influenza and pneumococcal vaccines in patients with COPD. The results showed that both vaccines, when used separately or together, effectively reduced the risk of acute exacerbations, pneumonia, and hospitalizations in COPD patients, with the greatest effectiveness seen in preventing acute exacerbations.
Article
Biochemistry & Molecular Biology
Linfan Su, Yixian Qiao, Jinmei Luo, Rong Huang, Yi Xiao
Summary: Frequent acute exacerbations are the leading cause of high rates of hospitalization and mortality in chronic obstructive pulmonary disease (COPD). Reliable molecular markers for effective early diagnosis and prognosis of acute exacerbations are still lacking. In this study, we explored the interaction between host genetics and airway microbiome in the pathogenesis of frequent exacerbations. We identified candidate mutated genes and significant differences in bacterial diversity and composition between frequent-exacerbation phenotype (FE) and infrequent-exacerbation phenotype (IE) COPD patients. Our findings suggest that exomes and related microbiomes may serve as potential biomarkers for predicting frequent acute exacerbations in COPD patients.
Editorial Material
Respiratory System
Aran Singanayagam, Sebastian L. Johnston
Editorial Material
Critical Care Medicine
Sebastian L. Johnston
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Medicine, Research & Experimental
Aleks Guvenel, Agnieszka Jozwik, Stephanie Ascough, Seng Kuong Ung, Suzanna Paterson, Mohini Kalyan, Zoe Gardener, Emma Bergstrom, Satwik Kar, Maximillian S. Habibi, Allan Paras, Jie Zhu, Mirae Park, Jaideep Dhariwal, Mark Almond, Ernie H. C. Wong, Annemarie Sykes, Jerico Del Rosario, Maria-Belen Trujillo-Torralbo, Patrick Mallia, John Sidney, Bjoern Peters, Onn Min Kon, Alessandro Sette, Sebastian L. Johnston, Peter J. Openshaw, Christopher Chiu
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Chemistry, Analytical
Tao Xiong, Mingle Li, Xueze Zhao, Yang Zou, Jianjun Du, Jiangli Fan, Xiaojun Peng
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Critical Care Medicine
Andrew I. Ritchie, Simon E. Brill, Ben H. Vlies, Lydia J. Finney, James P. Allinson, Luana Alves-Moreira, Dexter J. Wiseman, Paul P. Walker, Emma Baker, Sarah L. Elkin, Patrick Mallia, Martin Law, Gavin C. Donaldson, Peter M. A. Calverley, Jadwiga A. Wedzicha
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Review
Respiratory System
John Cafferkey, James Andrew Coultas, Patrick Mallia
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2020)
Editorial Material
Respiratory System
Philip G. Bardin, Sebastian L. Johnston
Editorial Material
Critical Care Medicine
Sebastian L. Johnston
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Editorial Material
Respiratory System
Chloe I. Bloom, Sebastian L. Johnston
Article
Critical Care Medicine
James P. Allinson, Ben H. Vlies, Simon E. Brill, Martin Law, Girvan Burnside, Lydia J. Finney, Luana Alves-Moreira, Gavin C. Donaldson, Peter M. A. Calverley, Paul P. Walker, Jadwiga A. Wedzicha
Summary: The study suggests that 12-month use of doxycycline did not significantly reduce the exacerbation rate in COPD patients, but it may be beneficial for those with severe COPD or high eosinophil counts.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Aran Singanayagam, Joseph Footitt, Matthias Marczynski, Giorgia Radicioni, Michael T. Cross, Lydia J. Finney, Maria-Belen Trujillo-Torralbo, Maria Calderazzo, Jie Zhu, Julia Aniscenko, Thomas B. Clarke, Philip L. Molyneaux, Nathan W. Bartlett, Miriam F. Moffatt, William O. Cookson, Jadwiga Wedzicha, Christopher M. Evans, Richard C. Boucher, Mehmet Kesimer, Oliver Lieleg, Patrick Mallia, Sebastian L. Johnston
Summary: During exacerbations of chronic respiratory diseases, the concentrations of airway mucus 5AC (MUC5AC) and MUC5B increase. Changes in MUC5AC expression are more sensitive to viral load, inflammation, symptom severity, decrements in lung function, and secondary bacterial infections during exacerbations. MUC5AC is functionally related to inflammation.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Respiratory System
Patrick Mallia, Jamilah Meghji, Brandon Wong, Kartik Kumar, Victoria Pilkington, Shaan Chhabra, Ben Russell, Jian Chen, Karthikan Srikanthan, Mirae Park, Harriet Owles, Felicity Liew, Joana Alcada, Laura Martin, Meg Coleman, Sarah Elkin, Clare Ross, Shweta Agrawal, Thomas Gardiner, Aaron Bell, Alice White, Dominic Hampson, Gauri Vithlani, Kavina Manalan, Solange Bramer, Alejandra Martin Segura, Anushree Kucheria, Prashanthi Ratnakumar, Alexander Sheeka, Lavanya Anandan, Susan Copley, Georgina Russell, Chloe Bloom, Onn Min Kon
Summary: Patients with COVID-19 may experience persistent symptoms and abnormal radiographic findings after discharge, with severity of the disease being a significant factor in determining the persistence of abnormalities. A proportion of patients also require unscheduled healthcare visits in the 30 days post discharge.
BMJ OPEN RESPIRATORY RESEARCH
(2021)
Meeting Abstract
Critical Care Medicine
L. Finney, P. S. Fenwick, S. Kemp, E. Bakhsoliani, K. B. R. Belchamber, M. R. Edwards, G. C. Donaldson, L. Donnelly, P. Mallia, S. L. Johnston, J. A. Wedzicha
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Physiology
Sanooj Soni, Justin L. Garner, Kieran P. O'Dea, Marissa Koh, Lydia Finney, Nikhil Tirlapur, Karthi Srikanthan, Eric D. Tenda, Arafa M. Aboelhassan, Suveer Singh, Michael R. Wilson, Jadwiga A. Wedzicha, Samuel Kemp, Omar S. Usmani, Pallav L. Shah, Masao Takata
Summary: This study comprehensively evaluated different MV populations in BALF and plasma of COPD patients, finding that BALF neutrophil-derived MVs were uniquely correlated with several key functional and clinically relevant disease severity indexes. This suggests the potential of BALF neutrophil MVs as a COPD biomarker that links intra-alveolar neutrophil activation with clinical severity/outcome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Respiratory System
Hugo Farne, Kartik Kumar, Andrew Ritchie, Lydia J. Finney, Sebastian L. Johnston, Aran Singanayagam
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2020)