Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

Phase I study of PF-03446962, a fully human mab against ALK 1, a TGFβ receptor involved in tumor angiogenesis.

(2017) L. W. Goff et al.   JOURNAL OF CLINICAL ONCOLOGY

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy

(2011) Laurens A. van Meeteren et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

(2011) Roselyne Castonguay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Bioinformatic Analysis of Pathogenic Missense Mutations of Activin Receptor Like Kinase 1 Ectodomain

(2011) Claudia Scotti et al.   PLoS One

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

(2010) Y. Suzuki et al.   JOURNAL OF CELL SCIENCE

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

(2010) Sara I. Cunha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth

(2010) D. Mitchell et al.   MOLECULAR CANCER THERAPEUTICS

ALK1 signaling regulates early postnatal lymphatic vessel development

(2009) K. Niessen et al.   BLOOD

Gastrosplenic Fistula From Hodgkin's Lymphoma

(2009) Carolyn D. Seib et al.   JOURNAL OF CLINICAL ONCOLOGY

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH