The Human Ion Channel TRPM2 Modulates Neuroblastoma Cell Survival and Mitochondrial Function through Pyk2, CREB, and MCU Activation

Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics

(2016) Lei Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation

(2016) Sangbin Lim et al.   Cell and Bioscience

Novel Role of Src in Priming Pyk2 Phosphorylation

(2016) Ming Zhao et al.   PLoS One

The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma

(2016) Ling-Yan Zhao et al.   Scientific Reports

Ca2+ entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance

(2015) Nicholas E. Hoffman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TRPM2-mediated intracellular Zn2+release triggers pancreatic β-cell death

(2015) Paul T. Manna et al.   BIOCHEMICAL JOURNAL

Enhanced cytotoxicity in triple-negative and estrogen receptor-positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel

(2015) DAVID W. KOH et al.   ONCOLOGY REPORTS

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

Adrenergic Signaling Regulates Mitochondrial Ca2+ Uptake Through Pyk2-Dependent Tyrosine Phosphorylation of the Mitochondrial Ca2+ Uniporter

(2014) Jin O-Uchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Pyk2 promotes tumor progression in multiple myeloma

(2014) Y. Zhang et al.   BLOOD

TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury

(2014) Barbara A. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α

(2014) Shu-jen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury

(2013) Barbara A. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

Pyk2 cytonuclear localization: mechanisms and regulation by serine dephosphorylation

(2012) Camille Faure et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer

(2012) M K Wendt et al.   ONCOGENE

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

(2010) John G. Starkus et al.   JOURNAL OF PHYSIOLOGY-LONDON

CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer Therapy

(2009) K. M. Sakamoto et al.   CLINICAL CANCER RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer

(2008) Byung Joo Kim et al.   CANCER SCIENCE

Identification of Pore Residues Engaged in Determining Divalent Cationic Permeation in Transient Receptor Potential Melastatin Subtype Channel 2

(2008) Rong Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death

(2008) Boyoung Lee et al.   JOURNAL OF NEUROCHEMISTRY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE