Pyk2 promotes tumor progression in multiple myeloma

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

(2014) I. M. Shapiro et al.   Science Translational Medicine

Proline-rich tyrosine kinase 2 and its phosphorylated form pY881 are novel prognostic markers for non-small-cell lung cancer progression and patients’ overall survival

(2013) B-H Kuang et al.   BRITISH JOURNAL OF CANCER

SHP-1-Pyk2-Src Protein Complex and p38 MAPK Pathways Independently Regulate IL-10 Production in Lipopolysaccharide-Stimulated Macrophages

(2013) C. Okenwa et al.   JOURNAL OF IMMUNOLOGY

Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma

(2013) Yang Liu et al.   PLoS One

Addiction to c-MYC in multiple myeloma

(2012) T. Holien et al.   BLOOD

Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma: A Review of the Current Understanding of Epidemiology, Biology, Risk Stratification, and Management of Myeloma Precursor Disease

(2012) A. Agarwal et al.   CLINICAL CANCER RESEARCH

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer

(2012) M K Wendt et al.   ONCOGENE

Focal Adhesion Kinase Splice Variants Maintain Primitive Acute Myeloid Leukemia Cells Through Altered Wnt Signaling

(2012) Mathieu Despeaux et al.   STEM CELLS

Compensatory Function of Pyk2 Protein in the Promotion of Focal Adhesion Kinase (FAK)-null Mammary Cancer Stem Cell Tumorigenicity and Metastatic Activity

(2011) Huaping Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma

(2011) W-J Chng et al.   LEUKEMIA

Focal adhesion kinase as a target in the treatment of hematological malignancies

(2011) Bu Yin   LEUKEMIA RESEARCH

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

(2010) Cedo M Bagi et al.   CANCER BIOLOGY & THERAPY

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

(2010) Isabelle Tanjoni et al.   CANCER BIOLOGY & THERAPY

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

(2010) Colin Walsh et al.   CANCER BIOLOGY & THERAPY

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma

(2009) A. M. Roccaro et al.   BLOOD

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

The prognostic significance of 8p21 deletion in multiple myeloma

(2008) T. Sutlu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY