Carbon monoxide in lung cell physiology and disease

A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis

(2018) Ivan O. Rosas et al.   CHEST

Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease

(2016) Seonmin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vascular and angiogenic activities of CORM-401, an oxidant-sensitive CO-releasing molecule

(2016) Sarah Fayad-Kobeissi et al.   BIOCHEMICAL PHARMACOLOGY

CO-releasing molecule (CORM) conjugate systems

(2016) Anna Christin Kautz et al.   DALTON TRANSACTIONS

Remote-controlled delivery of CO via photoactive CO-releasing materials on a fiber optical device

(2016) Steve Gläser et al.   DALTON TRANSACTIONS

Global estimates of carbon monoxide emissions from 1960 to 2013

(2016) Qirui Zhong et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Toward Carbon Monoxide–Based Therapeutics: Critical Drug Delivery and Developability Issues

(2016) Xingyue Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury

(2016) Yoon Kyung Choi et al.   NATURE MEDICINE

The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells

(2016) Felix Ulbrich et al.   PLoS One

Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

(2016) Stefan W. Ryter et al.   Translational Research

Carbon monoxide in the treatment of sepsis

(2015) Kiichi Nakahira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages

(2015) Sung-Soo Jung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide

(2015) Jesmond Dalli et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels

(2015) Patrycja Kaczara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway

(2015) Hyo Jeong Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

(2015) Md Jamal Uddin et al.   Cellular & Molecular Immunology

Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility

(2015) Sebastián A. Riquelme et al.   IMMUNOLOGY

Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation

(2015) SiYuan Qin et al.   INFLAMMATION RESEARCH

CORM-EDE1: A Highly Water-Soluble and Nontoxic Manganese-Based photoCORM with a Biogenic Ligand Sphere

(2015) Ralf Mede et al.   INORGANIC CHEMISTRY

c-Src-dependent transactivation of EGFR mediates CORM-2-induced HO-1 expression in human tracheal smooth muscle cells

(2015) Chuen-Mao Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gasotransmitters in cancer: from pathophysiology to experimental therapy

(2015) Csaba Szabo   NATURE REVIEWS DRUG DISCOVERY

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation

(2015) Peter W. Hewett et al.   THROMBOSIS AND HAEMOSTASIS

Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1

(2014) Masakazu Shinohara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide

(2014) Anuli C. Anyanwu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Diverse mechanisms underlying the regulation of ion channels by carbon monoxide

(2014) C Peers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel lead structures and activation mechanisms for CO-releasing molecules (CORMs)

(2014) U Schatzschneider   BRITISH JOURNAL OF PHARMACOLOGY

Design and Synthesis of New Hybrid Molecules That Activate the Transcription Factor Nrf2 and Simultaneously Release Carbon Monoxide

(2014) Jayne Louise Wilson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease

(2014) David J. Polhemus et al.   CIRCULATION RESEARCH

New modular manganese(i) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe

(2014) Sandesh Pai et al.   DALTON TRANSACTIONS

Introducing [Mn(CO)3(tpa-κ3N)]+ as a novel photoactivatable CO-releasing molecule with well-defined iCORM intermediates – synthesis, spectroscopy, and antibacterial activity

(2014) Christoph Nagel et al.   DALTON TRANSACTIONS

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Inhibition of the Cardiac Na+Channel Nav1.5 by Carbon Monoxide

(2014) Jacobo Elies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

(2014) Barbara Wegiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice

(2014) Bakytzhan Bakhautdin et al.   JOURNAL OF HEPATOLOGY

Carbon Monoxide Prevents Hypertension and Proteinuria in an Adenovirus sFlt-1 Preeclampsia-Like Mouse Model

(2014) Carolina C. Venditti et al.   PLoS One

Gasotransmitters: growing pains and joys

(2014) Rui Wang   TRENDS IN BIOCHEMICAL SCIENCES

Different design of enzyme-triggered CO-releasing molecules (ET-CORMs) reveals quantitative differences in biological activities in terms of toxicity and inflammation

(2014) E. Stamellou et al.   Redox Biology

Carbon Monoxide Confers Protection in Sepsis by Enhancing Beclin 1-Dependent Autophagy and Phagocytosis

(2013) Seonmin Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

(2013) B. Wegiel et al.   CANCER RESEARCH

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes

(2013) Francis Rousset et al.   PLoS One

Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia

(2012) Angeles Fernandez-Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8+T cells and protect from type 1 diabetes

(2012) Thomas Simon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Carbon Monoxide and Heme Oxygenase-1 Prevent Intestinal Inflammation in Mice by Promoting Bacterial Clearance

(2012) Joseph C. Onyiah et al.   GASTROENTEROLOGY

Vasorelaxing effects and inhibition of nitric oxide in macrophages by new iron-containing carbon monoxide-releasing molecules (CO-RMs)

(2012) Roberto Motterlini et al.   PHARMACOLOGICAL RESEARCH

Carbon Monoxide Improves Cardiac Function and Mitochondrial Population Quality in a Mouse Model of Metabolic Syndrome

(2012) Steve Lancel et al.   PLoS One

Postconditioning with Inhaled Carbon Monoxide Counteracts Apoptosis and Neuroinflammation in the Ischemic Rat Retina

(2012) Nils Schallner et al.   PLoS One

Carbon monoxide as an endogenous vascular modulator

(2011) Charles W. Leffler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Carbon Monoxide Activates Autophagy via Mitochondrial Reactive Oxygen Species Formation

(2011) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1

(2011) Mark L. Dallas et al.   FASEB JOURNAL

A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species

(2011) Luisa Lo Iacono et al.   FREE RADICAL BIOLOGY AND MEDICINE

Carbon monoxide: an emerging regulator of ion channels

(2011) William J. Wilkinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cysteine residue 911 in C-terminal tail of human BKCaα channel subunit is crucial for its activation by carbon monoxide

(2011) Vsevolod Telezhkin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors

(2011) William James Wilkinson et al.   Purinergic Signalling

Carbon Monoxide–Activated Nrf2 Pathway Leads to Protection Against Permanent Focal Cerebral Ischemia

(2011) Bing Wang et al.   STROKE

Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis

(2010) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation

(2010) Leah A. Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Nitric Oxide–Dependent Bone Marrow Progenitor Mobilization by Carbon Monoxide Enhances Endothelial Repair After Vascular Injury

(2010) Barbara Wegiel et al.   CIRCULATION

Dicarbonyl-bis(cysteamine)iron(II): A light induced carbon monoxide releasing molecule based on iron (CORM-S1)

(2010) Robert Kretschmer et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Carbon Monoxide-Releasing Micelles for Immunotherapy

(2010) Urara Hasegawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

Carbon Monoxide Rapidly Impairs Alveolar Fluid Clearance by Inhibiting Epithelial Sodium Channels

(2009) Mike Althaus et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HO-1 and CO Decrease Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cell Migration Via Inhibition of Nox1

(2009) Andres I. Rodriguez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels

(2009) WJ Wilkinson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Carbon monoxide prevents ventilator-induced lung injury via caveolin-1*

(2009) Alexander Hoetzel et al.   CRITICAL CARE MEDICINE

The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1

(2009) X. M. Wang et al.   JOURNAL OF IMMUNOLOGY

Carbon Monoxide Rescues Mice from Lethal Sepsis by Supporting Mitochondrial Energetic Metabolism and Activating Mitochondrial Biogenesis

(2009) S. Lancel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Modulation of hTREK-1 by carbon monoxide

(2009) Mark L. Dallas et al.   NEUROREPORT

An oxygen-sensitive mechanism in regulation of epithelial sodium channel

(2009) Su Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbon Monoxide Ameliorates Renal Cold Ischemia-Reperfusion Injury With an Upregulation of Vascular Endothelial Growth Factor by Activation of Hypoxia-Inducible Factor

(2009) Gaetano Faleo et al.   TRANSPLANTATION

Carbon monoxide activates NF-κB via ROS generation and Akt pathways to protect against cell death of hepatocytes

(2008) Hoe Suk Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Carbon Monoxide Protects against Ventilator-induced Lung Injury via PPAR-γ and Inhibition of Egr-1

(2008) Alexander Hoetzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Use of carbon monoxide as a therapeutic agent: promises and challenges

(2008) Roberta Foresti et al.   INTENSIVE CARE MEDICINE

Carbon Monoxide Inhibits L-type Ca2+Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species

(2008) Jason L. Scragg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme oxygenase-1–derived carbon monoxide enhances the host defense response to microbial sepsis in mice

(2008) Su Wol Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

Carbon monoxide–saturated preservation solution protects lung grafts from ischemia–reperfusion injury

(2008) Junichi Kohmoto et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BKCa channels

(2008) Sandile E. Williams et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels

(2008) S. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice

(2007) Gediminas Cepinskas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY