MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome

(2018) Karim Harhouri et al.   Nucleus

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome

(2018) Karim Harhouri et al.   Nucleus

Lamins in the nuclear interior − life outside the lamina

(2017) Nana Naetar et al.   JOURNAL OF CELL SCIENCE

miR-342-5p promotes Zmpste24-deficient mouse embryonic fibroblasts proliferation by suppressing GAS2

(2017) Chun-Long Zhang et al.   Molecular Medicine Reports

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Mechanisms and functions of nuclear envelope remodelling

(2017) Rosemarie Ungricht et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

microRNAs in skeletal muscle development

(2017) Gi Fay Mok et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of novel RNA isoforms of LMNA

(2017) Emily DeBoy et al.   Nucleus

MicroRNAs: pleiotropic players in congenital heart disease and regeneration

(2017) Sarah C. Hoelscher et al.   Journal of Thoracic Disease

Identification of novel RNA isoforms of LMNA

(2017) Emily DeBoy et al.   Nucleus

LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

(2016) Pauline Afonso et al.   ATHEROSCLEROSIS

RISC assembly: Coordination between small RNAs and Argonaute proteins

(2016) Hotaka Kobayashi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription

(2016) Weiliang Tang et al.   HUMAN MOLECULAR GENETICS

A network-biology perspective of microRNA function and dysfunction in cancer

(2016) Cameron P. Bracken et al.   NATURE REVIEWS GENETICS

MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine

(2016) Akira Sato et al.   PLoS One

Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells

(2016) Karim Harhouri et al.   Cells

Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging

(2016) Alexandra Dallaire et al.   Aging-US

An overview of microRNAs

(2015) Scott M. Hammond   ADVANCED DRUG DELIVERY REVIEWS

Miravirsen dosing in chronic hepatitis C patients results in decreased microRNA-122 levels without affecting other microRNAs in plasma

(2015) M. H. van der Ree et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Truncated prelamin A expression in HGPS-like patients: a transcriptional study

(2015) Florian Barthélémy et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mice that express farnesylated versions of prelamin A in neurons develop achalasia

(2015) Shao H. Yang et al.   HUMAN MOLECULAR GENETICS

MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24 -deficient mouse embryonic fibroblasts

(2015) Xing-dong Xiong et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database

(2015) Chih-Hung Chou et al.   NUCLEIC ACIDS RESEARCH

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

MicroRNA-dependent genetic networks during neural development

(2014) Daniel G. Abernathy et al.   CELL AND TISSUE RESEARCH

Development of microRNA therapeutics is coming of age

(2014) E. van Rooij et al.   EMBO Molecular Medicine

Identification and consequences of miRNA–target interactions — beyond repression of gene expression

(2014) Jean Hausser et al.   NATURE REVIEWS GENETICS

miRDB: an online resource for microRNA target prediction and functional annotations

(2014) Nathan Wong et al.   NUCLEIC ACIDS RESEARCH

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

(2014) Pierre Cau et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

Regulation of Myelination in the Central Nervous System by Nuclear Lamin B1 and Non-coding RNAs

(2014) Shu-Ting Lin et al.   Translational Neurodegeneration

Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction

(2013) Guillaume Bidault et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

(2013) Aleksandra Helwak et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

microRNAs in cardiac development and regeneration

(2013) Enzo R. Porrello   CLINICAL SCIENCE

New Lmna knock-in mice provide a molecular mechanism for the ‘segmental aging’ in Hutchinson–Gilford progeria syndrome†

(2013) Hea-Jin Jung et al.   HUMAN MOLECULAR GENETICS

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

(2013) Oliver Dreesen et al.   JOURNAL OF CELL BIOLOGY

MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24

(2013) K.-R. Yu et al.   JOURNAL OF CELL SCIENCE

MicroRNA in immunity and autoimmunity

(2013) Shu Zhu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extension

(2013) Xiankui Sun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinctive Serum miRNA Profile in Mouse Models of Striated Muscular Pathologies

(2013) Nicolas Vignier et al.   PLoS One

MicroRNA-23a promotes myelination in the central nervous system

(2013) S.-T. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An inheritedLMNAgene mutation in atypical Progeria syndrome

(2012) Yassamine Doubaj et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Identification of microRNA-regulated gene networks by expression analysis of target genes

(2012) Vincenzo Alessandro Gennarino et al.   GENOME RESEARCH

Understanding the Roles of Nuclear A- and B-type Lamins in Brain Development

(2012) Stephen G. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

(2012) Amy E. Pasquinelli   NATURE REVIEWS GENETICS

Loss of Emerin Alters Myogenic Signaling and miRNA Expression in Mouse Myogenic Progenitors

(2012) Adam J. Koch et al.   PLoS One

Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA

(2012) H.-J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Bioinformatics Analysis of Lamin-A Regulatory Network: A Perspective on Epigenetic Involvement in Hutchinson–Gilford Progeria Syndrome

(2012) Walter Arancio   REJUVENATION RESEARCH

Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA

(2012) Xavier Nissan et al.   Cell Reports

Micromanaging aging with miRNAs

(2012) Alejandro P. Ugalde et al.   Nucleus

LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue

(2011) Véronique Béréziat et al.   AMERICAN JOURNAL OF PATHOLOGY

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53

(2011) Alejandro P Ugalde et al.   EMBO JOURNAL

Type B mandibuloacral dysplasia with congenital myopathy due to homozygous ZMPSTE24 missense mutation

(2011) Rabah Ben Yaou et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

MicroRNA expression profiling in patients with lamin A/C-associated muscular dystrophy

(2011) Nicolas Sylvius et al.   FASEB JOURNAL

Nuclear lamins and laminopathies

(2011) Howard J. Worman   JOURNAL OF PATHOLOGY

Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs)

(2011) R. D. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation

(2010) Ashraf Malhas et al.   CELL CYCLE

microRNAs in diseases: from candidate to modifier genes

(2010) S Bandiera et al.   CLINICAL GENETICS

Small RNAs Guide Hematopoietic Cell Differentiation and Function

(2010) F. Navarro et al.   JOURNAL OF IMMUNOLOGY

Genome-wide Dissection of MicroRNA Functions and Cotargeting Networks Using Gene Set Signatures

(2010) John S. Tsang et al.   MOLECULAR CELL

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

miRBase: integrating microRNA annotation and deep-sequencing data

(2010) A. Kozomara et al.   NUCLEIC ACIDS RESEARCH

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

(2010) G. Marino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1

(2009) M M Ghodgaonkar et al.   CELL DEATH AND DIFFERENTIATION

miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination

(2009) S.-T. Lin et al.   Disease Models & Mechanisms

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

(2009) David G. Hendrickson et al.   PLOS BIOLOGY

De novoLMNAmutations cause a new form of congenital muscular dystrophy

(2008) Susana Quijano-Roy et al.   ANNALS OF NEUROLOGY

A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells

(2008) Catherine Coffinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Mandibuloacral Dysplasia-Associated Lipodystrophy and Progeria in a Young Girl with a Novel Homozygous Arg527CysLMNAMutation

(2008) Anil K. Agarwal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2

(2008) H. Houlden et al.   NEUROLOGY

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

(2008) J.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel LMNA Mutation in Atypical Werner Syndrome Presenting With Ischemic Disease

(2008) Dimitri Renard et al.   STROKE

MicroRNAs flex their muscles

(2008) Eva van Rooij et al.   TRENDS IN GENETICS